2018
DOI: 10.6061/clinics/2018/e813s
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Natural products as new antimitotic compounds for anticancer drug development

Abstract: Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because they induce cell cycle arrest and tumor cell death. These antitumor compounds are referred to as antimitotics. Vinca alkaloids and taxanes are natural products that target microtubules and inhibit mitosis, and t… Show more

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Cited by 38 publications
(24 citation statements)
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“…Nucleation of MTs is the initial step of mitotic spindle formation [15,16], and loss-of-function in MT-dependent MT ampli cation results in mitotic arrest [21,22]. Therefore, inhibition of mitotic spindle formation by targeting microtubule nucleation factors may be a promising anti-cancer strategy [23][24][25]. Many microtubule inhibitors, e.g.…”
Section: Discussionmentioning
confidence: 99%
“…Nucleation of MTs is the initial step of mitotic spindle formation [15,16], and loss-of-function in MT-dependent MT ampli cation results in mitotic arrest [21,22]. Therefore, inhibition of mitotic spindle formation by targeting microtubule nucleation factors may be a promising anti-cancer strategy [23][24][25]. Many microtubule inhibitors, e.g.…”
Section: Discussionmentioning
confidence: 99%
“…However, our study firstly revealed that scandenolone was toxic to normal hepatocytes and breast epithelial cells. To our knowledge most of the efficient natural compounds are not specific target to cancer cells, but can induce cells apoptosis, oncosis, DNA binding, antimitosis, mediate ATP-binding cassette transporters, MAPK, p53, NF-B, tubulin polymerization inhibition or some other pathways, which mostly exist in normal cells as well (Paier et al, 2018;Tewari et al, 2019). The compounds with lower toxicity usually have shown less efficiency of curing cancer, whereas the efficient ones may also show high toxicity to the normal cells.…”
Section: Discussionmentioning
confidence: 99%
“…In recent years, small natural compounds derived from herbal plants have drawn considerable attention due to their potential chemotherapeutic capacity and bio-safety ( Cianciosi et al, 2018 ; Paier et al, 2018 ). Accumulative data demonstrated that aloperine itself and the modified derivatives display powerful antitumor effect on various cancer types both in vivo and in vitro .…”
Section: Antitumor Effect Of Aloperinementioning
confidence: 99%