Natural products derived from plants as potential drugs for the photodynamic destruction of tumor cells

Ebermann, Robert; Alth, G; Kreitner, M.; Kubin, Andreas

doi:10.1016/s1011-1344(96)07353-8

Cited by 84 publications

(45 citation statements)

References 13 publications

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“…Hypericin is being evaluated for other antiviral and antineoplastic activities (6,(8)(9)(10)33). The plant from which it is derived, St. Johns wort, has wide use for the treatment of depression (5).…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics, Safety, and Antiviral Effects of Hypericin, a Derivative of St. John's Wort Plant, in Patients with Chronic Hepatitis C Virus Infection

Jacobson

Feinman

Liebes

et al. 2001

Antimicrob Agents Chemother

140

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Hypericin is a natural derivative of the common St. Johns wort plant, Hypericum perforatum. It has in vitro activity against several viruses, including bovine diarrhea virus, a pestivirus with structural similarities to hepatitis C virus (HCV). We conducted a phase I dose escalation study to determine the safety and antiviral activity of hypericin in patients with chronic HCV infection. The first 12 patients received an 8-week course of 0.05 mg of hypericin per kg of body weight orally once a day; 7 patients received an 8-week course of 0.10 mg/kg orally once a day. At the end of the 8-week period of treatment, no subject had a change of plasma HCV RNA level of more than 1.0 log 10 . Five of 12 subjects receiving the 0.05-mg/kg/day dosing schedule and 6 of 7 subjects receiving the 0.10-mg/kg/day dosing schedule developed phototoxic reactions. No other serious adverse events associated with hypericin use occurred. The pharmacokinetic data revealed a long elimination half-life (mean values of 36.1 and 33.8 h, respectively, for the doses of 0.05 and 0.1 mg/kg) and mean area under the curve determinations of 1.5 and 3.1 g/ml ؋ hr, respectively. In sum, hypericin given orally in doses of 0.05 and 0.10 mg/kg/d caused considerable phototoxicity and had no detectable anti-HCV activity in patients with chronic HCV infection.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics, Safety, and Antiviral Effects of Hypericin, a Derivative of St. John's Wort Plant, in Patients with Chronic Hepatitis C Virus Infection

Jacobson

Feinman

Liebes

et al. 2001

Antimicrob Agents Chemother

140

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“…Okra seeds were determined to have appreciable protein content according to Akingbala et al, (2003). The variations in polysaccharides found in the mucilage are higher in okra pods according to Hirose et al, (2004) and 2014 Green vegetables contain valuable chlorophyll (Ebermann et al, 2006). Chlorophyllin as an important component of chlorophyll was reported for enormous health benefits.…”

Section: Nutritional Composition Of Okramentioning

confidence: 99%

Nutritional Quality and Health Benefits of Okra (Abelmoschus esculentus): A Review

Gemede¹,

Ratta²,

Haki³

et al. 2015

J Food Process Technol

187

158

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Okra (Abelmoschus esculentus) is an economically important vegetable crop grown in tropical and sub-tropical parts of the world. This paper was aimed to review nutritional quality and potential health benefits of edible parts of Okra. Okra is a multipurpose crop due to its various uses of the fresh leaves, buds, flowers, pods, stems and seeds. Okra immature fruits, which are consumed as vegetables, can be used in salads, soups and stews, fresh or dried, fried or boiled. It offers mucilaginous consistency after cooking. Often the extract obtained from the fruit is added to different recipes like stews and sauces to increase the consistency. Okra mucilage has medicinal applications when used as a plasma replacement or blood volume expander. The mucilage of okra binds cholesterol and bile acid carrying toxins dumped into it by the liver. Okra seeds are a potential source of oil, with concentrations varying from 20% to 40%, which consists of linoleic acid up to 47.4%. Okra seed oil is also a rich source of linoleic acid, a polyunsaturated fatty acid essential for human nutrition. Okra has been called "a perfect villager's vegetable" because of its robust nature, dietary fiber, and distinct seed protein balance of both lysine and tryptophan amino acids. The amino acid composition of okra seed protein is comparable to that of soybean and the protein efficiency ratio is higher than that of soybean and the amino acid pattern of the protein renders it an adequate supplement to legume or cereal based diets. Okra seed is known to be rich in high quality protein especially with regards to its content of essential amino acids relative to other plant protein sources. Okra is a powerhouse of valuable nutrients, nearly half of which is soluble fibre in the form of gums and pectins which help to lower serum cholesterol, reducing the risk of heart diseases. The other fraction of Okra is insoluble fibre, which helps to keep the intestinal tract healthy. Okra is also abundant with several carbohydrates, minerals and vitamins, which plays a vital role in human diet and health. Okra is rich in phenolic compounds with important biological properties like quartering and flavonol derivatives, catechin oligomers and hydroxycinnamic derivatives. Okra is also known for being high in antioxidants activity. Okra has several potential health beneficial effects on some of the important human diseases like cardiovascular disease, type 2 diabetes, digestive diseases and some cancers. Overall, Okra is an important vegetable crop with a diverse array of nutritional quality and potential health benefits.

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“…These polyacetylenes have shown to be highly toxic towards fungi, bacteria and mammalian cells and to display neurotoxic, antiinflammatory and anti-platelet-aggregatory effects and to be responsible for allergic skin reactions (10). Also some members of Apiaceae family are reported to cause photosensitization (11,12), because of these reasons they have to be used carefully.…”

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confidence: 99%

An ethnobotanical study of the useful and edible plants of Izmit

Kizilarslan¹

2012

mpj

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An ethnobotanical study was carried out in İzmit province (Northwest Turkey). During this study, 145 specimens were collected from the area. Informations about plants such as their usages and used parts were recorded. The stud y revealed that, 96 plant taxa belonging to 42 families had ethnobotanical usages in this area. Among these 96 plant taxa, 60 taxa (51 wild, 9 cultivated) were used as edibles and 64 taxa (51 wild, 13 cultivated) were used for different purposes. The results of our study show that even in countrys that are situated in close proximity to metropolitan cities, the ethnobotanical usages of plants are still alive.

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Natural products derived from plants as potential drugs for the photodynamic destruction of tumor cells

Cited by 84 publications

References 13 publications

Pharmacokinetics, Safety, and Antiviral Effects of Hypericin, a Derivative of St. John's Wort Plant, in Patients with Chronic Hepatitis C Virus Infection

Pharmacokinetics, Safety, and Antiviral Effects of Hypericin, a Derivative of St. John's Wort Plant, in Patients with Chronic Hepatitis C Virus Infection

Nutritional Quality and Health Benefits of Okra (Abelmoschus esculentus): A Review

An ethnobotanical study of the useful and edible plants of Izmit

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