Natural products for the management of xerostomia: a randomized, double‐blinded, placebo‐controlled clinical trial

Morante, Anabel Navarro; Wolff, Ändy; Mendoza, Gloria Rocío Bautista; Pia, López-Jornet

doi:10.1111/jop.12487

Cited by 18 publications

(25 citation statements)

References 26 publications

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“…Though all the patients suffered from dry mouth, included participants were a mixed population of elderly patients, those with dry mouth after radiation therapy, with medication‐induced dry mouth or dry mouth of unknown origin . The number of participants ranged from 19 to 60 . In 4 out of 7 studies the number of women was greater than men .…”

Section: Resultsmentioning

confidence: 99%

“… Saliva Orthana ® (Nycomed Ltd, Buckinghamshire, UK), topical spray which is a mucin‐based saliva substitute containing NaF iO Natural Antioxidant is an extra virgin olive oil with lycopene 300 ppm (Vianoleo SL, Badajoz, Spain) …”

Section: Resultsmentioning

confidence: 99%

“…Unstimulated salivary flow was measured by various methods. Navarro Morante et al and Kerr et al used passive drooling, Nagy et al, Gomez‐Moreno et al, and Epstein et al used spitting. Stimulated salivary flow was measured by either chewing nonflavored Wrigley's™ gum base or chewing 1 gram piece of paraffin wax for an assigned period of time and then measured …”

Section: Resultsmentioning

confidence: 99%

“…Six studies reported the outcome of unstimulated salivary flow . Due to the heterogeneity of the interventions (Biotėne ® products and 1% malic acid) we performed subgroup analyses.…”

Section: Resultsmentioning

confidence: 99%

“…Search was updated on March 21, 2018 and 1 relevant RCT was found as well as 1 recent systematic review …”

Section: Methodsmentioning

confidence: 99%

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Efficacy of saliva substitutes and stimulants in the treatment of dry mouth

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Mohammadi

Han³

et al. 2019

Special Care in Dentistry

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Aims To evaluate the efficacy of saliva substitutes and stimulants compared to placebo in improving findings of dry mouth not caused by Sjӧgren's. Methods and Results Four databases were searched (PubMed, Web of Science, Cochrane Library, and EMBASE) through March 2018. Only randomized controlled trials (RCT) using placebo interventions with dry mouth patients were included. Outcomes included salivary flow and self‐reported patient improvement. The Cochrane Collaboration's tool for assessing risk of bias was used. A total of 348 references were reviewed, resulting in 7 RCTs with 257 dry mouth patients with 5 studies at high risk of bias, 1 unclear and 1 low risk being included. Topical spray of 1% malic acid increased unstimulated (Difference in Means [DM] = 0.096, 95% CI = 0.092‐0.100; P < 0.001) and stimulated (DM = 0.203, 95% CI = 0.106‐0.300; P < 0.001) salivary flow in 2 studies. Patients using 1% malic acid topical spray were 5.4 times more likely to report improvement compared to placebo (95% CI = 2.634‐11.091; P < 0.001) in 2 studies. No significant improvements were found with other products when compared to placebo. Conclusion Use of 1% malic acid topical spray seems to improve dry mouth compared to placebo. Quality of the evidence was low due to risk of bias and imprecision.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

“…Six studies reported the outcome of unstimulated salivary flow . Due to the heterogeneity of the interventions (Biotėne ® products and 1% malic acid) we performed subgroup analyses.…”

Section: Resultsmentioning

confidence: 99%

“…Search was updated on March 21, 2018 and 1 relevant RCT was found as well as 1 recent systematic review …”

Section: Methodsmentioning

confidence: 99%

See 3 more Smart Citations

Efficacy of saliva substitutes and stimulants in the treatment of dry mouth

See

Mohammadi

Han³

et al. 2019

Special Care in Dentistry

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Natural Oral Care and Herbal Products for Oral Diseases and Oral Hygiene Maintenance

Kathayat,

Selvido,

Skallevold

et al. 2023

Pharmacological Studies in Natural Oral Care

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Saliva substitute mouthwash in nasopharyngeal cancer survivors with xerostomia: a randomized controlled trial

et al. 2020

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Objectives Xerostomia is a prevalent sequelae among nasopharyngeal cancer (NPC) survivors; yet, effective treatment protocols have been elusive. This study was a prospective randomized clinical trial to compare the effects of saliva substitute mouthwash in nasopharyngeal cancer survivors with xerostomia, between two treatment arms, conducted in a tertiary center. Materials and methods This study measured the effects within 4 weeks in relation to summated xerostomia inventory (SXI) and unstimulated whole saliva (UWS). Patients randomized into the interventional arm were prescribed an immunologically active saliva substitute (IASS), while patients in the control arm were prescribed a non-immunologically active mouthwash as placebo. Results The study population consisted of 94 patients. There was a significant difference in SXI difference (p < 0.0001) and UWS difference (p < 0.0001) between control and interventional arms. No harmful side effects associated with the use of either mouthwash encountered throughout the study duration. Conclusion IASS mouthwash significantly reduces subjective xerostomia scores measured using SXI and improves objective measurement of salivary flow using UWS among nasopharyngeal cancer survivors with xerostomia. Clinical relevance IASS is significantly more effective in improving subjective and objective xerostomia measurements compared to non-immunologically active mouthwash. Additionally, this treatment is very safe, with superior side effect profiles. Trial registration ClinicalTrials.gov Identifier: NCT04491435

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Natural products for the management of xerostomia: a randomized, double‐blinded, placebo‐controlled clinical trial

Abstract: The topical application of lycopene-enriched virgin olive oil and its placebo counterpart improved xerostomia-related symptoms significantly (but not salivary flow rate) in patients with drug-induced xerostomia.

Cited by 18 publications

References 26 publications

Efficacy of saliva substitutes and stimulants in the treatment of dry mouth

Efficacy of saliva substitutes and stimulants in the treatment of dry mouth

Natural Oral Care and Herbal Products for Oral Diseases and Oral Hygiene Maintenance

Saliva substitute mouthwash in nasopharyngeal cancer survivors with xerostomia: a randomized controlled trial

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