Natural products from Bacillus subtilis with antimicrobial properties

Wang, Tao; Liang, Yafei; Wu, Mianbin; Chen, Zhengjie; Lin, Johnson; Yang, Lirong

doi:10.1016/j.cjche.2014.05.020

Cited by 107 publications

(96 citation statements)

References 153 publications

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“…This was not evident in the current study. [20]. Reduction in surface tension is also observed in other cultures with B. subtilis present and includes cultures with leather dust present as well.…”

Section: Bacterial Interaction With Chromiummentioning

confidence: 65%

“…Bacillus species have been identified as producers of a large class of biosurfactants called lipopeptides, which consist of a cyclic polypeptide linked to a long fatty acid chain [20]. They can be divided into several groups which include surfactins, fengycins and iturins [20].…”

Section: Exploitation Of Value-added Products From Detoxification Promentioning

confidence: 99%

“…B. subtilis is known to synthesise a class of biosurfactants called lipopeptides [20]. Therefore in the current investigation surface tension was recorded to test for any indication of biosurfactant that may be produced in the experimental groups.…”

Section: Surface Tension Measurementsmentioning

confidence: 99%

“…They can be divided into several groups which include surfactins, fengycins and iturins [20]. Following centrifugation of samples collected from the leather dust detoxification fermentation, the cell free supernatant was used to test the surface tension of the liquid for any indication of biosurfactant production.…”

Section: Exploitation Of Value-added Products From Detoxification Promentioning

confidence: 99%

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Biosurfactant Production and Biodegradation of Leather Dust from Tannery

Greenwell¹,

Sarker²,

Rahman³

2016

TOBIOTJ

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Background:The leather industry contributes vast amounts of pollution damaging to aquatic and terrestrial environments. Leather dust is a chromium-contaminated waste produced from the shaving and buffering processes involved in leather tanning. Microorganisms have been investigated for their usefulness in bioremediation and recycling of waste materials. Solid leather waste is the current focus of material to be remediated in this study. Objective:The present work focuses on the development of a process to degrade the leather dust protein with the aim of removing the chromium bound within the protein. As part of the study, detecting the presence of biosurfactant production was performed to fuel further interest in value-added by-products of the process. Method:Bacillus subtilis SA-6 was used to treat the leather dust over a 10 day shake flask study. Daily samples were taken and analysed for chromium content by Atomic Absorption Spectrometry. The surface tension of the shake flask cultures was also investigated to detect for any valuable by-products such as biosurfactants for future prospects of developing an economically viable process. Results:Chromium concentration demonstrated an exponential increase between 0-120 h in shake flask experiments. In the presence of B. subtilis SA-6 chromium concentration in cell free supernatant increased from 0.13±0.09 mg/L to 190.81±20.18 mg/L compared to when B. subtilis SA-6 was absent. Surface tension decreased during fermentation from 53.23±0.92 mN/m to 30.13±0.15 mN/m in 24 h. Conclusion:This study demonstrates a waste management process, which detoxifies solid tannery waste to reduce environmental pollution, whilst yielding value-added products (such as biosurfactant) to provide an economically viable bioprocess with potential for large-scale development.

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Section: Bacterial Interaction With Chromiummentioning

confidence: 65%

Section: Exploitation Of Value-added Products From Detoxification Promentioning

confidence: 99%

Section: Surface Tension Measurementsmentioning

confidence: 99%

Section: Exploitation Of Value-added Products From Detoxification Promentioning

confidence: 99%

See 2 more Smart Citations

Biosurfactant Production and Biodegradation of Leather Dust from Tannery

Greenwell¹,

Sarker²,

Rahman³

2016

TOBIOTJ

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“…Lipopeptides directly antagonize phytopathogens by (i) inducing host plant immunization through root colonization in the rhizosphere and by (ii) interrupting the pathogen's abilities to permeate cell membranes (Mongkolthanaruk 2012). Surfactins are the most comprehensively studied lipopeptide family and contain approximately 20 different lipopeptides (Wang et al 2015). Although surfactins differ in the composition of their amino acids, they all have a cyclic heptapeptide structure and they are known to exhibit various biological activities such as antibacterial, antiviral and even haemolytic activity (Aleti et al 2015).…”

Section: Cyclic Lipopeptidesmentioning

confidence: 99%

Microbial metabolomics: essential definitions and the importance of cultivation conditions for utilizing Bacillus species as bionematicides

Horak

Engelbrecht

Rensburg

et al. 2019

J of Applied Microbiology

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Root‐knot nematodes are destructive phytopathogens that damage agricultural crops globally, and there is growing interest in the use of biocontrol based on rhizobacteria such as Bacillus to combat Meloidogyne species. It is hypothesized that nematicidal activity of Bacillus can be attributed to the production of secondary metabolites and hydrolytic enzymes. Yet, few studies have characterized these metabolites and their identities remain unknown. Others are speculative or fail to elaborate on how secondary metabolites were detected or distinguished from primary metabolites. Metabolites can be classified based on their origin as either intracellular or extracellular and based on their function, as either primary or secondary. Although this classification is in general use, the boundaries are not always well defined. An understanding of the secondary metabolite and hydrolytic enzyme classification of Bacillus species will facilitate investigations aimed at bionematicide development. This review summarizes the significance of Bacillus hydrolytic enzymes and secondary metabolites in bionematicide research and provides an overview of known classifications. The importance of appropriate cultivation conditions for optimum metabolite and enzyme production is also discussed. Finally, the use of metabolomics for the detection and identification of nematicidal compounds is considered.

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Modeling and optimization of antibacterial effect of lichen‐associated bacteria, Bacillus subtilis KSRLAB3 strain against marine fouling bacteria, Vibrio alginolyticus

Subbaiyan¹,

Ganesan²

2023

Biotech and App Biochem

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One of the most commonly occurring bacteria, Bacillus subtilis, can produce a wide variety of secondary metabolites. In this study, the antimicrobial effect of B. subtilis KSRLAB3 against Vibrio alginolyticus was optimized using the Plackett–Burman design (PBD) method, response surface methodology (RSM), and genetic algorithm (GA). Initially, the effects of carbon source, nitrogen source, NaCl concentration, pH, temperature, and incubation time on antimicrobial effects were studied. Among the carbon and nitrogen sources investigated, mannose and peptone elicited maximum antimicrobial effect. Using PBD, the most significant variables that influence the antimicrobial effect were identified, including incubation time, peptone concentration, and temperature. The optimum conditions required for attaining maximum antimicrobial effect was identified using the RSM‐GA hybrid method, and the optimum condition includes 49.999 h of incubation time, 4.39 g/L of peptone concentration, and 27.629°C of incubation temperature. The confirmatory experiments performed around the optimum condition showed a zone of inhibition of 35 ± 0.52 mm. Methanolic extract also proved the presence of antibacterial lipopeptide surfactin. Therefore, the RSM‐GA hybrid method was successfully used in this study to model the antimicrobial effect of B. subtilis KSRLAB3 against V. alginolyticus. The effective inhibition of V. alginolyticus can be investigated further for the development of antifouling coatings.

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Natural products from Bacillus subtilis with antimicrobial properties

Cited by 107 publications

References 153 publications

Biosurfactant Production and Biodegradation of Leather Dust from Tannery

Biosurfactant Production and Biodegradation of Leather Dust from Tannery

Microbial metabolomics: essential definitions and the importance of cultivation conditions for utilizing Bacillus species as bionematicides

Modeling and optimization of antibacterial effect of lichen‐associated bacteria, Bacillus subtilis KSRLAB3 strain against marine fouling bacteria, Vibrio alginolyticus

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