Natural Products from Mangroves: An Overview of the Anticancer Potential of Avicennia marina

Cerri, Federico; Giustra, Marco; Anadol, Yaprak; Tomaino, Giulia; Galli, Paolo; Labra, Massimo; Campone, Luca; Colombo, Miriam

doi:10.3390/pharmaceutics14122793

Cited by 8 publications

(5 citation statements)

References 42 publications

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“…Meanwhile, terpenoids have different biological activities ( Mitić et al, 2017 ), including good antibacterial activity ( Patra & Mohanta, 2014 ), cytotoxic and antiviral activity ( Gong et al, 2017 ), and moderate cytotoxic and antimicrobial activities ( Cerri et al, 2022 ). Terpenes and terpenoids are the main bioactive compounds of essential oils ( Masyita et al, 2022 ), which have been comprehensively studied and reported to play critical roles in human health ( Perveen, 2018 ).…”

Section: Discussionmentioning

confidence: 99%

Comparative analysis of flavonoids, polyphenols and volatiles in roots, stems and leaves of five mangroves

Shang

Xie

2023

PeerJ

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Mangrove plants contain a variety of secondary metabolites, including flavonoids, polyphenols, and volatiles, which are important for their survival and adaptation to the coastal environment, as well as for producing bioactive compounds. To reveal differences in these compounds among five mangrove species’ leaf, root, and stem, the total contents of flavonoids and polyphenols, types and contents of volatiles were determined, analyzed and compared. The results showed that Avicennia marina leaves contained the highest levels of flavonoids and phenolics. In mangrove parts, flavonoids are usually higher than phenolic compounds. A total of 532 compounds were detected by a gas chromatography-mass spectrometry (GC-MS) method in the leaf, root, and stem parts of five mangrove species. These were grouped into 18 classes, including alcohols, aldehydes, alkaloids, alkanes, etc. The number of volatile compounds in A. ilicifolius (176) and B. gymnorrhiza (172) was lower than in the other three species. The number of volatile compounds and their relative contents differed among all three parts of five mangrove species, where the mangrove species factor had a greater impact than the part factor. A total of 71 common compounds occurring in more than two species or parts were analyzed by a PLS-DA model. One-way ANOVA revealed 18 differential compounds among mangrove species and nine differential compounds among parts. Principal component analysis and hierarchical clustering analysis showed that both unique and common compounds significantly differed in composition and concentration between species and parts. In general, A. ilicifolius and B. gymnorrhiza differed significantly from the other species in terms of compound content, while the leaves differed significantly from the other parts. VIP screening and pathway enrichment analysis were performed on 17 common compounds closely related to mangrove species or parts. These compounds were mainly involved in terpenoid pathways such as C10 isoprenoids and C15 isoprenoids and fatty alcohols. The correlation analysis showed that the content of flavonoids/phenolics, the number of compounds, and the content of some common compounds in mangroves were correlated with their salt and waterlogging tolerance levels. These findings will help in the development of genetic varieties and medicinal utilization of mangrove plants.

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Section: Discussionmentioning

confidence: 99%

Comparative analysis of flavonoids, polyphenols and volatiles in roots, stems and leaves of five mangroves

Shang

Xie

2023

PeerJ

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“…The number of compounds isolated from A. marina extracts and tested against cancer cell lines is still limited. This encourages further investigation in this context to find new, natural, active molecules extracted from A. marina that can be employed as new drugs in cancer treatments (Cerri et al, 2022).…”

Section: Avicennia Marinamentioning

confidence: 96%

Some Medicinal Plants with Anti-breast Cancer Activity and the Input of Phytotherapy in the Treatment of Breast Cancer

Anago,

Gaetan Segbo,

Gnangnon

et al. 2023

ESJ

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Aim: Breast cancer is the most commonly diagnosed cancer leading to death among women worldwide. Despite the advances in the diagnosis skills and in the treatment of breast cancer, it has been observed that the recurrence rate experienced by breast cancer patients is quite high. Many plants have been reported to have anti-breast cancer properties. This paper focuses on determining the role of phytotherapy in the treatment of breast cancer. Methods: The following key search terms were used on Pubmed, Google scholar, and Researchgate: breast cancer, breast cancer cell lines, phytotherapy, medicinal plants in the treatment of breast cancer, treatment of breast cancer, cytotoxics effects of plant extracts on breast cancer in vitro/ in vivo, integrative oncology, and natural products as sources of drugs. Pertinent reviews in English language were examined. Results: It has been observed that many studies were conducted in vitro and in vivo to demonstrate the anti-breast cancer activities of a myriad of plants. While investigations are being made to prove the anti-breast cancer effects of many plants, the use of phytomedicine is not generating enough attention by mainstream practitioners. Some significant results were observed by patients with breast cancer history through the combination of phytotherapy and conventional medicines. Discussion: The conventional treatment of breast cancer is often accompanied with side effects. Many patients in low-income countries are faced off with the enormous cost of conventional treatment. Hence, there is a need to search for new bioactive substances in the treatments of breast cancer. Phytotherapy is a promising approach and herbal preparations are to be used in the same way as conventional medicine in the treatment of breast cancer. Conclusion: Phytotherapeutics products are used more often in the treatment of breast cancer as adjuvant therapy. In Africa, the use of herbal products in the treatment of breast cancer still remains in the hands of traditional-practitioners, without any control of quality and efficacy. Standard methods for the preparation of herbal products are to be determined in order to adopt phytotherapy in the treatment of breast cancer as much as conventional treatment.

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“…It has also been observed that alkylated benzoquinones isolated from the stem and twigs of Aegiceras corniculatum had varying degrees of selective cytotoxicity against cell lines HL-60, HepG2, BGC-823, and A2780 (Li et al 2020). Two flavonoids obtained from methanol extracts of aerial parts of Avicennia marina proved to be cytotoxic against the cell line BT 20 (Cerri et al 2022).…”

Section: Antiviral and Anticancer Activitymentioning

confidence: 99%

Unique adaptations and bioresources of mangrove ecosystems

Ramesh,

Sajan,

Namitha

et al. 2024

EEB

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Mangroves are unique ecosystems. As they are present in a transition zone, they harbour a variety of organisms, which include microorganisms, aquatic as well as terrestrial organisms. Being present in an ever-changing and adverse environment, mangroves have developed several adaptations that make them unique. These unique features have been exploited for the isolation of various useful compounds from mangroves. The organisms associated with the mangrove ecosystem will also be well equipped to survive such extreme conditions. Microorganisms such as bacteria, fungi, actinomycetes, algae etc, survive in this changing environment, and they might be producing certain metabolites as a part of their survival mechanism, which can be exploited for the production of various compounds that are useful to mankind. Mangrove microorganisms can be used as an important source of food, medicines, enzymes, antimicrobials etc.

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Natural Products from Mangroves: An Overview of the Anticancer Potential of Avicennia marina

Cited by 8 publications

References 42 publications

Comparative analysis of flavonoids, polyphenols and volatiles in roots, stems and leaves of five mangroves

Comparative analysis of flavonoids, polyphenols and volatiles in roots, stems and leaves of five mangroves

Some Medicinal Plants with Anti-breast Cancer Activity and the Input of Phytotherapy in the Treatment of Breast Cancer

Unique adaptations and bioresources of mangrove ecosystems

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