Natural source, bioactivity and synthesis of 3-Arylcoumarin derivatives

Zhang, Qiang; Miao, Yu-Hang; Li, Teng; Yun, Yinling; X, Sun; Yang, Tao; Sun, Jie

doi:10.1080/14756366.2022.2058499

Cited by 9 publications

(6 citation statements)

References 117 publications

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“…The search for natural-source compounds with pharmacological properties has resulted in the discovery of one of the many new molecules with critical applications [ 1 , 2 ]. Ethiopia stands out as a potential source of these natural chemicals because it has the highest plant biodiversity in the world and the bulk of its species are yet to be found in terms of their therapeutic potential [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antibacterial and Antioxidant Activities of Stem Bark Essential Oil and Extracts of Solanecio gigas

Yitayeh

Wassihun

2022

Biochemistry Research International

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Herbal medication developed from natural resources has to have antibacterial and antioxidant effects. The aim of this research is to look at the chemical makeup of Solanecio gigas (S. gigas) stem bark essential oil (EO), as well as the effectiveness of EO and extracts (chloroform, ethyl acetate, and methanol) against human pathogenic bacteria and their antioxidant activity. The GC-MS analysis identified 23 components, accounting for 98.7% of the total oil containing Methylene chloride (49.2%), sabinene (10.5%), 1-nonene (11.3%), Terpinen-4-ol (6.9%), Camphene (4.3%), γ-terpinene (3.6%), α-phellandrene (2.9%) β-myrcene (2.6%), 1,2,5-Oxadiazol-3-carboxamide, 4,4′-azobis-2,2′-dioxide (2.4%), α-terpinene (1.9%), 1-Octanamine, N-methyl- (1.9%), ρ-cymene (1.6%) as major components. The antibacterial efficacy of the EO and extracts (25, 50, 100, and 200 mg/ml) was demonstrated by the inhibitory zones (8.5 ± 0.47–23.3 ± 0.36 and 7.2 ± 0.25–22.0 ± 0.45 mm), respectively. The MIC values of the extracts and the EO were 120–150 and 240 to <1100 μg/ml, respectively. The EO also demonstrated a significant antibacterial impact. The EO and methanolic extract had free radical scavenging activities with IC50 value, 13.8 ± 0.48 and 4.2 ± 0.04 μg/ml, respectively. In comparison to the other extracts, the methanolic extract had the greatest phenolics (100.2 ± 0.13 μg GAE/mg of dry extract) and flavonoid contents (112.1 ± 0.18 μg CE/mg of dry extract).

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Section: Introductionmentioning

confidence: 99%

Chemical Composition and Antibacterial and Antioxidant Activities of Stem Bark Essential Oil and Extracts of Solanecio gigas

Yitayeh

Wassihun

2022

Biochemistry Research International

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“…This condition is becoming more widespread every day, and it primarily affects the elderly. Recent studies have demonstrated that this disease can be managed by PDCs [137] …”

Section: Results From the Reviewing And Their Related Discussionmentioning

confidence: 99%

Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

Younes,

Mustafa

2024

Chemistry & Biodiversity

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Plant‐derived coumarin (PDC) is a naturally occurring heterocyclic backbone that belongs to the benzopyrone family. PDC and its based products are characterized by low toxicity and high distribution in a variety of herbal treatments that have numerous therapeutic potentials. These include anticoagulants, antibacterials, anti‐inflammatory agents, anticancer agents, antioxidants, and others. So, it may be appropriate to investigate the qualities and potential bioactivities of PDCs. This article provides an overview of the biomedical potentials, availability, and clinical use possibilities of PDCs, with a focus on their important modes of action, using information on various pharmacological qualities discovered. The data used in this study came from published research between 2015 and 2023. We reviewed a selection of databases, including PubMed, Scopus, Web of Science, and Google Scholar, during that period. In conclusion, because of their abundance in medicinal plants, the clinical biochemistry attributes of PDCs are currently of interest. In a variety of medical specialties, PDCs serve a useful role as therapeutic agents.

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“…Non-competitive inhibition involves a molecule that binds to a location on the enzyme other than the active site, thereby altering the enzyme’s conformation and reducing its activity. Uncompetitive inhibition involves a molecule that binds to the enzyme-substrate complex, preventing the enzyme from catalysing the reaction 4 .…”

Section: Introductionmentioning

confidence: 99%

Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope

Al-Omari,

Elaarag,

Al-Zoubi

et al. 2023

Journal of Enzyme Inhibition and Medicinal Chemistry

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Boronic acids/esters have recently emerged in the field of medicinal and pharmaceutical research due to their exceptional oxophilicity, low toxicity, and unique structure. They are known as potent enzyme inhibitors, cancer therapy capture agents, and can mimic certain types of antibodies to fight infections. They have been designed and developed into drugs, and this approach has emerged in the last 20 years. Five boronic acid drugs have been approved by the FDA and Health Canada, two of which are used to treat cancer, specifically multiple myeloma. The purpose of this review is to investigate boronic acid/ester derivatives as potential pharmaceutical agents as well as the mechanism of action. It will concentrate on six types of cancer: multiple myeloma, prostate cancer, breast cancer, lung cancer, cervical cancer, and colon cancer. Some newly developed boron-containing compounds have already demonstrated highly promising activities, but further investigation is required before final conclusions can be drawn.

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Natural source, bioactivity and synthesis of 3-Arylcoumarin derivatives

Cited by 9 publications

References 117 publications

Chemical Composition and Antibacterial and Antioxidant Activities of Stem Bark Essential Oil and Extracts of Solanecio gigas

Chemical Composition and Antibacterial and Antioxidant Activities of Stem Bark Essential Oil and Extracts of Solanecio gigas

Plant‐Derived Coumarins: A Narrative Review of Their Structural and Biomedical Diversity

Organoboronic acids/esters as effective drug and prodrug candidates in cancer treatments: challenge and hope

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