Natural Support for Autoimmune and Inflammatory Disease

Abstract

Autoimmune diseases such as rheumatoid arthritis (RA), ankylosing spondylitis, and systemic lupus erythematosus (SLE), involve destruction of healthy cells by the body's own defensive mechanism. If the immune system's faux pas is not corrected, the attack can progress to the heart, lungs, and other vital organs. The mechanisms that cause the deregulation of the immune response are not entirely understood. It can be assumed that heavy metal toxicity, leaky gut syndrome, infectious bacteria and parasites, and nutritional imbalances can overburden the body's immune system, thus deregulating immune signals and responses. Ongoing research investigates the mechanism by which these factors cause the immune system to attack the body's own tissues. In this paper, we discuss natural therapies that can help regulate the immune system's aggressive behavior without suppressing or altering its necessary defenses.

Network pharmacology combined with an experimental validation study to reveal the effect and mechanism of Lonicera japonica Thunb. extracts against immunomodulation

“…Macrophages are crucial in the inflammatory reaction that fights against infection, yet macrophages could be attacked due to prolonged inflammatory stress (Zampieron & Kamhi, 2012). Hence, it is vital to maintain the immune response homeostasis by reducing uncontrolled inflammation.…”

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“…The isogarcinol, active compound from Garcinia mangostana L. inhibite Calcineurin unique protein phosphatase, plays an important role in immune regulation in a dose-dependent manner 19 . Natural therapies help to regulate the immune system's aggressive behavior without suppressing necessary defenses 20 .…”

Forecasting of potential anti-inflammatory targets of some immunomodulatory plants and their constituents using in vitro, molecular docking and network pharmacology-based analysis

“…Uncertainties surround the mechanisms behind immune response dysregulation. It is conceivable that excessive exposure to heavy metals, pathogenic bacteria and parasites, leaky gut syndrome and dietary imbalances can tax the immune system to the point where it becomes dysregulated 2 . Despite the fact that there are more than 100 different forms of autoimmune diseases; rheumatoid arthritis, multiple sclerosis, lupus, psoriasis, type 1 diabetes and others are the most prevalent ones 3 .…”