Naturally available hypericin undergoes electron transfer for type I photodynamic and photothermal synergistic therapy

Abstract

Hypericin undergoing electron transfer can be used for type I PDT and PTT.

Synthesis of a new photosensitizer for ablation of Uppsala 87 Malignant Glioma cells

“…The cell viability ability decreased dramatically, and the half maximal inhibitory concentration of BTR NPs is 12.8 μg/mL (6.63 μM), which is a little higher than that of the previously reported 3,6- bis(5-(4-(9Hcarbazol-9-yl)phenyl)furan-2-yl)-2,5-bis(2octyldodecyl)pyrrolo [3,4-c]pyrrole-1,4(2H,5H)-dione (7.1 μg/mL, 5.41 μM) [15] but lower than that of hypericin (5.6 μg/mL, 11.1 μM). [33] In addition, we have added a cell viability assay using normal human cells, including L02 cells and HEK cells, to evaluate the dark phototoxicity of photosensitizer (Figure S4). The results indicated that this photosensitizer has a low toxicity on normal cells.…”

Recent Advances in Strategies for Addressing Hypoxia in Tumor Photodynamic Therapy

“…Because of the oxygen-independent property of type I PDT, a variety of materials were designed and prepared to regulate the PDT mechanism and enhance type I PDT [ 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 ]. It is recognized that for the majority of photosensitizers, type I and II pathways typically exist simultaneously but competitively [ 48 , 49 , 50 , 51 ]. Till now, full understanding of the mechanism of transformation from type II to type I mechanism is still a great challenge.…”

A highly efficient polydopamine encapsulated clinical ICG theranostic nanoplatform for enhanced photothermal therapy of cervical cancer

“…7 At present, PTT has been applied to the in vitro and in vivo biomedical researches. [8][9][10][11][12] With the continuous development of research related to PTT, majority of PTAs have been developed and studied, including platinum, Au nanoparticles (NPs), MoSe 2 , Indocyanine Green (ICG), new Indocyanine Green (IR820) and so on. [13][14][15][16][17] Although, a variety of PTAs have been utilized, there is still a great demand for photothermal materials with good biosafety and photothermal property.…”