Nature-Inspired Bio-Microfluidic Device by Soft Lithography Technique &lt;tex&gt;$\cdot$&lt;/tex&gt;

Priyadarshani, Jyotsana; Chakraborty, Suman; Das, Soumen

doi:10.1109/icsens.2018.8589750

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Offering decisive advantages in regard to their ability to mimic human physiological features on a chip, − as well as providing study platforms facilitating dynamic visualization of the underlying phenomena under controlled alterations in the relevant field effects, it is envisaged that findings on nanoparticle penetration in biomimetic microengineered platforms may enable predicting the targeted therapeutic outcome in sufficient advance, shortening lengthy animal trials that otherwise have only less than 8% rate of successful translation to human therapies . Advent of such novel drug-target efficacy assessment platforms gives a further scope of redesigning parameters for improving the treatment protocols as and when required.…”

Section: Introductionmentioning

confidence: 99%

Targeting Magnetic Nanoparticles in Physiologically Mimicking Tissue Microenvironment

Bhattacharya

Priyadarshani

et al. 2022

ACS Appl. Mater. Interfaces

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Magnetic nanoparticles as drug carriers, despite showing immense promises in preclinical trials, have remained to be only of limited use in real therapeutic practice primarily due to unresolved anomalies concerning their grossly contrasting controllability and variability in performance in artificial test benches as compared to human tissues. To circumvent the deficits of reported in vitro drug testing platforms that deviate significantly from the physiological features of the living systems and result in this puzzling contrast, here, we fabricate a biomimetic microvasculature in a flexible tissue phantom and demonstrate distinctive mechanisms of magnetic-field-assisted controllable penetration of biocompatible iron oxide nanoparticles across the same, exclusively modulated by tissue deformability, which has by far remained unraveled. Our experiments deciphering the transport of magnetic nanoparticles in a blood analogue medium unveil a decisive interplay of the flexibility of the microvascular pathways, magnetic pull, and viscous friction toward orchestrating the optimal vascular penetration and targeting efficacy of the nanoparticles in colorectal tissue-mimicking bioengineered media. Subsequent studies with biological cells confirm the viability of using localized magnetic forces for aiding nanoparticle penetration within cancerous lesions. We establish nontrivially favorable conditions to induce a threshold force for vascular rupture and eventual target of the nanoparticles toward the desired extracellular site. These findings appear to be critical in converging the success of in vitro trials toward patient-specific targeted therapies depending on personalized vascular properties obtained from medical imaging data.

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Section: Introductionmentioning

confidence: 99%

Targeting Magnetic Nanoparticles in Physiologically Mimicking Tissue Microenvironment

Bhattacharya

Priyadarshani

et al. 2022

ACS Appl. Mater. Interfaces

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“…The corner effects in fabrication, thus produced, affect the flow velocity and wall shear stress (WSS) distribution across the channel in a manner that deviates far from the scenario prevalent in physiological vessels. As a consequence, alternative methods such as nature-inspired soft lithography, , single-channel circular fluidic devices, ,, direct writing assembly, inkjet printing, and layer by layer assembly approach have subsequently emerged, in an effort to provide effective alternative fabrication perspectives. However, putting aside the successes of these methods, some serious constraints remain on the material selection, biomimetic channel circularity, hierarchical complexity, flexibility, and cellular compatibility.…”

Section: Introductionmentioning

confidence: 99%

Frugal Approach toward Developing a Biomimetic, Microfluidic Network-on-a-Chip for In Vitro Analysis of Microvascular Physiology

Priyadarshani

Roy

Das

et al. 2021

ACS Biomater. Sci. Eng.

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Several disease conditions, such as cancer metastasis and atherosclerosis, are deeply connected with the complex biophysical phenomena taking place in the complicated architecture of the tiny blood vessels in human circulatory systems. Traditionally, these diseases have been probed by devising various animal models, which are otherwise constrained by ethical considerations as well as limited predictive capabilities. Development of an engineered network-on-a-chip, which replicates not only the functional aspects of the blood-carrying microvessels of human bodies, but also its geometrical complexity and hierarchical microstructure, is therefore central to the evaluation of organ-assist devices and disease models for therapeutic assessment. Overcoming the constraints of reported resource-intensive fabrication techniques, here, we report a facile, simple yet niche combination of surface engineering and microfabrication strategy to devise a highly ordered hierarchical microtubular network embedded within a polydimethylsiloxane (PDMS) slab for dynamic cell culture on a chip, with a vision of addressing the exclusive aspects of the vascular transport processes under medically relevant paradigms. The design consists of hierarchical complexity ranging from capillaries (∼80 μm) to large arteries (∼390 μm) and a simultaneous tuning of the interfacial material chemistry. The fluid flow behavior is characterized numerically within the hierarchical network, and a confluent endothelial layer is realized on the inner wall of microfluidic device. We further explore the efficacy of the device as a vascular deposition assay of circulatory tumor cells (MG-63 osteosarcoma cells) present in whole blood. The proposed paradigm of mimicking an in vitro vascular network in a low-cost paradigm holds further potential for probing cellular dynamics as well as offering critical insights into various vascular transport processes.

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Bio-inspired microfluidics: A review

Raj M,

Priyadarshani,

Karan

et al. 2023

Biomicrofluidics

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Biomicrofluidics, a subdomain of microfluidics, has been inspired by several ideas from nature. However, while the basic inspiration for the same may be drawn from the living world, the translation of all relevant essential functionalities to an artificially engineered framework does not remain trivial. Here, we review the recent progress in bio-inspired microfluidic systems via harnessing the integration of experimental and simulation tools delving into the interface of engineering and biology. Development of “on-chip” technologies as well as their multifarious applications is subsequently discussed, accompanying the relevant advancements in materials and fabrication technology. Pointers toward new directions in research, including an amalgamated fusion of data-driven modeling (such as artificial intelligence and machine learning) and physics-based paradigm, to come up with a human physiological replica on a synthetic bio-chip with due accounting of personalized features, are suggested. These are likely to facilitate physiologically replicating disease modeling on an artificially engineered biochip as well as advance drug development and screening in an expedited route with the minimization of animal and human trials.

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Nature-Inspired Bio-Microfluidic Device by Soft Lithography Technique <tex>$\cdot$</tex>

Cited by 3 publications

References 21 publications

Targeting Magnetic Nanoparticles in Physiologically Mimicking Tissue Microenvironment

Targeting Magnetic Nanoparticles in Physiologically Mimicking Tissue Microenvironment

Frugal Approach toward Developing a Biomimetic, Microfluidic Network-on-a-Chip for In Vitro Analysis of Microvascular Physiology

Bio-inspired microfluidics: A review

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