Nausea and the quest for the perfect anti-emetic

Cyclophosphamide Administration Routine in Autoimmune Rheumatic Diseases: A Review

“…58 Moreover, dexamethasone was added prior to chemotherapy, as a prophylactic agent to anaphylactic shock and also as an antiemetic. 59 Preferably, dexamethasone should be administered so that its peak coincides with the peak of physiological corticosteroids, which normally occurs at 8 a.m. and 16 p.m. 58 A peak in dexamethasone plasma concentration occurs within 60 min, and its action begins in 30 min. 55,60 Thus, the administration of dexamethasone should be started in the morning, 30 min before the administration of cyclophosphamide, preferably at 7:30 a.m. 58 After the emesis caused by cyclophosphamide was classified as a delayed-type, 56 and in view of the decrease of cyclophosphamide efficacy when ondansetron is administered prior to this chemotherapeutic agent, ondansetron (8 mg PO 31,61 administered at 6 and 14 or 8 and 16 h post-ChT, and with a maximum dose of 16 mg after chemotherapy, not exceeding 32 mg per day) was the last drug used for the prophylaxis of emesis caused by cyclophosphamide.…”

Ginger for prevention of antiretroviral-induced nausea and vomiting: a randomized clinical trial

“…This concept that antiemetics are more efficacious against vomiting than nausea was reviewed recently by Andrews and Sanger [27].…”

Nausea and vomiting in palliative care

“…9 Cannabinoids (such as nabilone) mediate an antiemetic effect through the CB 1 receptor and anecdotally can be used with good effect in selected patients with refractory nausea, although evidence to date is limited to a role in chemotherapy related nausea when standard agents have failed. 10 Competing interests: We have read and understood BMJ policy on declaration of interests and have no relevant interests to declare.…”