Nausea and vomiting during pregnancy associated with lower incidence of preterm births: the Japan Environment and Children’s Study (JECS)

Mitsuda, Naomi; Eitoku, Masamitsu; Yamasaki, Kazuhiko; Sakaguchi, Masahiko; Yasumitsu‐Lovell, Kahoko; Maeda, Nobuyo; Fujieda, Mikiya; Suganuma, Narufumi

doi:10.1186/s12884-018-1911-1

Cited by 12 publications

(16 citation statements)

References 24 publications

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“…Besides, some studies reported an association between NVP and increased risk of PTB [9,11], or LBW [9,11,14]. However, other studies reported lower risk of PTB [17,18], or LBW [19] in pregnant women who experienced NVP.…”

Section: Discussionmentioning

confidence: 99%

“…Some studies have shown that NVP is associated with adverse pregnancy outcomes, such as increased risk of preterm birth (PTB) [8][9][10][11], low birth weight (LBW) [8,9,[11][12][13][14], and neural tube defects [15,16]. While, some studies suggested that NVP has protective effects on pregnancy outcomes, such as lower risk of PTB [13,17,18], LBW [19], small for gestational age (SGA) [19], and pregnancy loss [20][21][22]. Still, no associations between NVP and PTB [19,23], LBW [18,23], or SGA [24] have been reported in other literatures.…”

Section: Introductionmentioning

confidence: 99%

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Evaluation of nausea and vomiting in the first trimester on the risk of adverse birth outcomes and the contribution of genetic polymorphisms: a pilot prospective study

Xue

et al. 2022

Arch Gynecol Obstet

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To evaluate the impact of Nausea and vomiting in pregnancy (NVP) on the risk of preterm birth (PTB) and low birth weight (LBW), and explore the effect of genetic polymorphisms on the severity of NVP. MethodsA prospective study was conducted. Participants' experience of NVP prior to 12 gestational weeks were evaluated by a Pregnancy-Unique Quanti cation of Emesis and Nausea (PUQE) scale. 11 Single Nucleotide Polymorphisms (SNPs) loci located in growth differentiation factor 15 (GDF15) and leucine rich repeat containing 25 (LRRC25) gene of chr19p13.11 and intergenic region of chr4q12 were genotyped, which were implicated as genetic risk factors for NVP. Logistic regression models were applied to determine the effect of NVP in the rst trimester on the risk of PTB and LBW, and genetic polymorphisms on the risk of NVP. ResultsAmong 413 pregnant women, the incidence of nausea and vomiting was 85.5% (n = 353) in the rst trimester, including 38.7% (n = 160) mild vomiting, 42.6%(n = 176) moderate vomiting and 4.1% (n = 17) severe vomiting. 33 were PTB, 20 were LBW. Compared with pregnant women without NVP, women with mild, moderate or severe NVP in the rst trimester were not associated with the risk of PTB and LBW. Besides, the polymorphisms of 11 SNPs loci were not associated with the risk of NVP. ConclusionsOur study indicated that symptoms of nausea and vomiting in the rst trimester were not signi cantly associated with PTB and LBW, and there were also no associations between GDF15 and LRRC25 polymorphisms and NVP. What Does This Study Add?This study indicated that maternal nausea and vomiting in early pregnancy was not associated with adverse birth outcomes, including preterm birth and low birth weight, and the polymorphisms of GDF15 and LRRC25 were not associated with the risk of NVP in Chinese pregnant women.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Evaluation of nausea and vomiting in the first trimester on the risk of adverse birth outcomes and the contribution of genetic polymorphisms: a pilot prospective study

Xue

et al. 2022

Arch Gynecol Obstet

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“…Typical NVP occurs during the first trimester and is self-limiting, subsiding before 20 weeks of gestation [2]. It is considered to represent a healthy pregnancy, which has been linked to favorable obstetric and neonatal outcomes, including lower risk of miscarriage [3] and reduced odds for low birth weight and preterm birth [4,5].…”

Section: Introductionmentioning

confidence: 99%

Severe nausea and vomiting in pregnancy: psychiatric and cognitive problems and brain structure in children

Wang

Rolls

et al. 2020

BMC Med

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Background: Two studies have suggested that severe prolonged nausea and vomiting during pregnancy is associated with emotional and behavioral problems in offspring, with smaller sample size and short-term follow-up. Moreover, little information is available on the role of the brain structure in the associations. Methods: In a US-based cohort, the association was investigated between severe prolonged nausea and vomiting in pregnancy (extending after the second trimester and termed SNVP), psychiatric and cognitive problems, and brain morphology, from the Adolescent Brain Cognitive Development (ABCD) study, from 10,710 children aged 9-11 years. We validated the emotional including psychiatric findings using the Danish National Cohort Study with 2,092,897 participants. Results: SNVP was significantly associated with emotional and psychiatric problems (t = 8.89, Cohen's d = 0.172, p = 6.9 × 10 −19) and reduced global cognitive performance (t = − 4.34, d = − 0.085, p = 1.4 × 10 −5) in children. SNVP was associated with low cortical area and volume, especially in the cingulate cortex, precuneus, and superior medial prefrontal cortex. These lower cortical areas and volumes significantly mediated the relation between SNVP and the psychiatric and cognitive problems in children. In the Danish National Cohort, severe nausea and vomiting in pregnancy were significantly associated with increased risks of behavioral and emotional disorders in children (hazard ratio, 1.24; 95% confidence interval, 1.16-1.33). Conclusions: SNVP is strongly associated with psychiatric and cognitive problems in children, with mediation by brain structure. These associations highlight the clinical importance and potential benefits of the treatment of SNVP, which could reduce the risk of psychiatric disorder in the next generation.

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“…Research shows that 33–83% of pregnant women experience nausea and vomiting of pregnancy (NVP) 1–4 . Other than nausea and vomiting, NVP also leads to loss of appetite and weight gain, affecting activities of daily living and sleep 5 .…”

Section: Introductionmentioning

confidence: 99%

The NVP QOL Questionnaire: Psychometric properties of the self‐report measure of health‐related quality of life for nausea and vomiting during pregnancy

et al. 2022

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Aim: The Nausea and Vomiting of Pregnancy Quality of Life (NVP QOL) Questionnaire is a self-report measure of health-related QOL for nausea and vomiting during pregnancy.This study determines the best fitting factor structure for the NVP QOL Questionnaire and explores its measurement invariance in terms of observation time and parity.Methods: A test-retest study of pregnant women was conducted at Gestational Weeks (GWs) 10-13 (T1: N = 381) and 1 week later (T2: n = 128) at one hospital and five clinics with the NVP QOL and the Pregnancy-Unique Quantification of Emesis and Nausea (PUQE). Exploratory and confirmatory factor analyses were performed to compare different factor structure models and evaluate measurement invariance of the best fitting model between two time points and between primiparas and multiparas.Concurrent validity of the NVP QOL was clarified by correlations with the PUQE, Sheehan Disability Scale, and other scales. Results:The one-factor model had the best fit. This factor structure model was acceptable up to the factor invariance level for two time points and up to the factor mean level for primiparas versus multiparas. Correlations between NVP QOL, PUQE, and Sheehan Disability Scale scores were strong. Women with higher NVP QOL scores were more likely to lose weight, have lower daily fluid intake, have reduced fluid and food intake since pregnancy began, and receive outpatient or inpatient treatment. Conclusion:The one-factor structure and measurement invariance of the NVP QOL at different times and parities were demonstrated, suggesting that the NVP QOL can be used to evaluate primiparas and multiparas in a longitudinal study.

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Nausea and vomiting during pregnancy associated with lower incidence of preterm births: the Japan Environment and Children’s Study (JECS)

Cited by 12 publications

References 24 publications

Evaluation of nausea and vomiting in the first trimester on the risk of adverse birth outcomes and the contribution of genetic polymorphisms: a pilot prospective study

Evaluation of nausea and vomiting in the first trimester on the risk of adverse birth outcomes and the contribution of genetic polymorphisms: a pilot prospective study

Severe nausea and vomiting in pregnancy: psychiatric and cognitive problems and brain structure in children

The NVP QOL Questionnaire: Psychometric properties of the self‐report measure of health‐related quality of life for nausea and vomiting during pregnancy

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