Nausea and Vomiting in a Diabetic Patient with Delayed Gastric Emptying: Do not Delay Diagnosis

Gulati, Rishabh; Khalid, Sameen; Tafoya, Marissa; McCarthy, Denis M.

doi:10.1007/s10620-019-05482-0

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…In some cases of Sarcina infection in humans, symptoms are preceded by evidence of delayed gastric emptying 69,70,[97][98][99] . With ENGS, however, affected chimpanzees appeared healthy prior to the onset of signs.…”

Section: Discussionmentioning

confidence: 99%

A Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leone

Owens

Colitti

Hirji³

et al. 2021

Nat Commun

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Human and animal infections with bacteria of the genus Sarcina (family Clostridiaceae) are associated with gastric dilation and emphysematous gastritis. However, the potential roles of sarcinae as commensals or pathogens remain unclear. Here, we investigate a lethal disease of unknown etiology that affects sanctuary chimpanzees (Pan troglodytes verus) in Sierra Leone. The disease, which we have named “epizootic neurologic and gastroenteric syndrome” (ENGS), is characterized by neurologic and gastrointestinal signs and results in death of the animals, even after medical treatment. Using a case-control study design, we show that ENGS is strongly associated with Sarcina infection. The microorganism is distinct from Sarcina ventriculi and other known members of its genus, based on bacterial morphology and growth characteristics. Whole-genome sequencing confirms this distinction and reveals the presence of genetic features that may account for the unusual virulence of the bacterium. Therefore, we propose that this organism be considered the representative of a new species, named “Candidatus Sarcina troglodytae”. Our results suggest that a heretofore unrecognized complex of related sarcinae likely exists, some of which may be highly virulent. However, the potential role of “Ca. S. troglodytae” in the etiology of ENGS, alone or in combination with other factors, remains a topic for future research.

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Section: Discussionmentioning

confidence: 99%

A Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leone

Owens

Colitti

Hirji³

et al. 2021

Nat Commun

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“…After a full-text review, all the remaining articles were considered eligible and were included in the systematic review. Thus, a total of 55 articles reporting 65 cases of SV were found (Aggarwal et al, 2018;Alvin et al, 2018;Behzadi et al, 2017;Berry et al, 2015;Bhagat et al, 2015;Bommannan et al, 2016;Bortolotti et al 2019;Canan et al, 2017;Carrigan et al, 2015;Chan et al, 2020;Chougule et al, 2015;Cox II et al, 2020;Darch et al, 2016;De Meij et al, 2017;Dey et al, 2019;DiMaio et al, 2014;Dolganiuc et al, 2017;Dumitru et al, 2020;Elvert et al, 2018;Fanaroff et al, 2020;Gulati et al, 2019;Haroon Al Rasheed et al,2016;Heidinger et al, 2020;Hillman et al, 2020;Karakus et al, 2014;Khan et al, 2016;Kulkarni et al, 2013;Kumar et al, 2014;Laass et al, 2010;Lam-Himlin et al, 2011;Liu et al, 2018;Lopez et al, 2020;Louis et al, 2014;Medlicott et al, 2015;Mironova et al, 2017;Nepplet et al, 2018;Perrault et al, 2021;Perrault et al, 2021;Propst et al, 2020;Rajasekar et al, 2016;Ratuapli et al, 2013;…”

Section: Study Selectionmentioning

confidence: 99%

Sarcina Ventriculi infection: a rare but fearsome event. A Systematic Review of the Literature

Tartaglia

Coccolini

Mazzoni

et al. 2022

International Journal of Infectious Diseases

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This is a PDF file of an article that has undergone enhancements after acceptance, such as the addition of a cover page and metadata, and formatting for readability, but it is not yet the definitive version of record. This version will undergo additional copyediting, typesetting and review before it is published in its final form, but we are providing this version to give early visibility of the article. Please note that, during the production process, errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain.

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Antibiotic susceptibility screening of primate-associated Clostridium ventriculi

et al. 2021

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Nausea and Vomiting in a Diabetic Patient with Delayed Gastric Emptying: Do not Delay Diagnosis

Cited by 3 publications

References 17 publications

A Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leone

A Sarcina bacterium linked to lethal disease in sanctuary chimpanzees in Sierra Leone

Sarcina Ventriculi infection: a rare but fearsome event. A Systematic Review of the Literature

Antibiotic susceptibility screening of primate-associated Clostridium ventriculi

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