Navigation surgery using indocyanine green fluorescent imaging for hepatoblastoma patients

Souzaki, Ryota; Kawakubo, Naonori; Matsuura, Toshiharu; Yoshimaru, Koichiro; Koga, Yuhki; Takemoto, Junkichi; Shibui, Yuichi; Kohashi, Kenichi; Hayashida, Miyeko; Oda, Yoshinao; Ohga, Shouichi; Taguchi, Tomoaki

doi:10.1007/s00383-019-04458-5

Cited by 56 publications

(53 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Some clinical centers have reported the use of ICG molecular fluorescence imaging technology for the diagnosis and treatment of liver tumors [3][4][5][6]29]. However, whether it can improve the surgical treatment of liver tumors is still lack of domestic and foreign high-quality evidence.…”

Section: Discussionmentioning

confidence: 99%

“…It is not easy to distinguish the color difference between the left and right hemipatic by just blocking the flow of blood into the right hemipatial blood on the hepatic surface marker tangent line, even inject methylene blue into the right portal vein to stain the right hemihepatic, therefore it is difficult to improve the precision of hepatectomy. In recent years, with the rapid development of molecular imaging technology, indocyanine green (ICG), as a near-infrared fluorescent dye, has been intensively applied in the field of liver surgery [3][4][5][6]. By injecting ICG into the corresponding liver segment or the liver lobe, we are able to develop an ICG fluorescence imaging system (photodynamic eye) to guide precise hepatectomy.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Precise right hemihepatectomy for the treatment of hepatocellular carcinoma guided by fusion ICG fluorescence imaging

Yao¹,

Zhang²,

Ma³

et al. 2020

J. Cancer

View full text Add to dashboard Cite

To evaluate the clinical significance of fusion indocyanine green (ICG) fluorescence imaging in precise right hemihepatectomy for the treatment of hepatocellular carcinoma (HCC). 47 patients with HCC who underwent right hemihepatectomy were retrospectively analyzed. 18 of them guided by fusion ICG fluorescence imaging (FIGFI) while 29 patients underwent conventional right hepatectomy without guidance. Compared to the patients with conventional treatment, the intraoperative blood loss of the patients with guided surgery was significantly less, and no transfusion and hepatic occlusion were performed during the operation. Liver function recovery faster in guided group. The incidence of postoperative complications is also lower, and the recurrence rate in one year is significantly reduced. ICG fluorescence range of 18 patients in liver surface was consistent with the ischemic line, and their postoperative liver cross-sections were clearly demarcation. There were no significant differences in the mean operation time, blood loss, postoperative hospital stays, cases of blood transfusion, complication rate, or postoperative peak volume of ALT and TB between positive or negative staining groups. Pathology results of all patients demonstrated HCC and negative margins, and microvascular invasion occurred in 8 cases. The average follow-up time of 18 patients was 16.7 months, and recurrence was found in 5 cases after surgery. FIGFI could guide the anatomical right hepatectomy with real-time increased radical rate, accuracy and safety for the treatment of HCC, and therefore showed a promising prospect.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Precise right hemihepatectomy for the treatment of hepatocellular carcinoma guided by fusion ICG fluorescence imaging

Yao¹,

Zhang²,

Ma³

et al. 2020

J. Cancer

View full text Add to dashboard Cite

show abstract

“…Tumour tissue will thus remain fluorescent and this facilitates real-time identification of a primary tumour as well as any metastatic lesions under infrared light. 3 The benefit of ICG fluorescence is more important during laparoscopic surgery since its fluorescent property compensates for the inability of LH to examine the whole liver in its absence. The tumour margin is also more obvious under ICG fluorescence imaging as the tumour appears much brighter.…”

Section: Discussionmentioning

confidence: 99%

Indocyanine green fluorescence-assisted laparoscopic hepatectomy for hepatocellular carcinoma in a pre-adolescent girl: a case report

2020

View full text Add to dashboard Cite

We present the case of a 9-year-old Chinese girl who presented with an incidental finding of elevated alkaline phosphatase (349 U/L) during a routine medical examination in 2018. Further blood test results were positive for hepatitis B. The patient was prescribed entecavir 0.5 mg daily and underwent regular liver ultrasound scans. After 6 months, a tumour at the right lobe of the liver was identified during routine scanning, and serum alphafetoprotein was elevated at 489 ng/mL. Further investigation with contrast computed tomography scan revealed a 3.8-cm × 5.0-cm tumour at segment 5 of the liver with radiological features compatible with hepatocellular carcinoma (HCC, Fig 1a). Liver function tests were normal (total bilirubin: 12 µmol/L, albumin 38 g/L, international normalised ratio:1.1). The patient's body weight was 28 kg and her height was 128 cm. Laparoscopic segment 5 resection was suggested. Intravenous indocyanine green (ICG) at a dosage of 0.5 mg/kg was administered 24 hours before surgery with no adverse effects. The following day, laparoscopic hepatectomy (LH) was performed under general anaesthesia. The patient was placed in a reverse Trendelenburg position with her right side mildly elevated and three 10-mm and two 5-mm abdominal ports created. Intra-operatively, a

show abstract

“…The system allows for easy switching between white light and ICG modes using a foot pedal. This system has been utilized in laparoscopic hepatectomy for hepatic tumors [34,35] and HB [36].…”

Section: Modalitiesmentioning

confidence: 99%

Fluorescence-Guided Surgery for Hepatoblastoma with Indocyanine Green

Yamada

Ohno

Fujino

et al. 2019

Cancers

View full text Add to dashboard Cite

Fluorescence-guided surgery with indocyanine green (ICG) for malignant hepatic tumors has been gaining more attention with technical advancements. Since hepatoblastomas (HBs) possess similar features to hepatocellular carcinoma, fluorescence-guided surgery can be used for HBs, as aggressive surgical resection, even for distant metastases of HBs, often contributes positively to R0 (complete) resection and subsequent patient survival. Despite a few caveats, fluorescence-guided surgery allows for the more sensitive identification of lesions that may go undetected by conventional imaging or be invisible macroscopically. This leads to precise resection of distant metastatic tumors as well as primary liver tumors.

show abstract

Navigation surgery using indocyanine green fluorescent imaging for hepatoblastoma patients

Cited by 56 publications

References 11 publications

Precise right hemihepatectomy for the treatment of hepatocellular carcinoma guided by fusion ICG fluorescence imaging

Precise right hemihepatectomy for the treatment of hepatocellular carcinoma guided by fusion ICG fluorescence imaging

Indocyanine green fluorescence-assisted laparoscopic hepatectomy for hepatocellular carcinoma in a pre-adolescent girl: a case report

Fluorescence-Guided Surgery for Hepatoblastoma with Indocyanine Green

Contact Info

Product

Resources

About