2022
DOI: 10.1101/2022.01.31.478434
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NCOA4 drives ferritin phase separation to facilitate macroferritinophagy and endosomal microferritinophagy

Abstract: A ferritin particle consists of 24 ferritin proteins (FTH1 and FTL) and stores iron ions within it. During iron deficiency, ferritin particles are transported to lysosomes to release iron ions. Two transport pathways have been reported: macroautophagy and ESCRT-dependent endosomal microautophagy. Although the membrane dynamics of these pathways differ, both require NCOA4, which is thought to be an autophagy receptor for ferritin. However, the exact function of NCOA4 remains elusive. Here, we found that ferriti… Show more

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Cited by 2 publications
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