Near‐infrared aggregation‐induced emission materials: Bibliometric analysis and their application in biomedical field

Abstract

Aggregation‐induced emission (AIE) is an intriguing photophysical phenomenon, where specific materials exhibit a remarkable surge in luminescence when brought together in non‐ideal solvents or within a solid matrix. Since the concept of AIE was first introduced in 2001, numerous advanced applications have been gradually explored across various domains, including optics, electronics, energy, and the life sciences. Of particular note is the growing interest in the application of AIE systems with near‐infrared (NIR) emissive feature in the field of biomedicine, encompassing detection, imaging, and therapeutic interventions. Notably, bibliometric analysis serves as a valuable tool to provide researchers with a comprehensive understanding of research achievements and developmental trends in specific fields, which is crucial for academic research. Herein, we present a general bibliometric overview spanning two decades of NIR‐AIE development. With the assistance of core scientific databases and various bibliometric software tools, we conducted a systematic analysis of annual publications and citations, the most influential countries/regions, leading authors, journals, and institutions, as well as the hot topics related to NIR applications and forward‐looking predictions. Furthermore, the application of AIE with NIR properties in the biomedical field is also systematically reviewed.

Anthraquinone-Centered Type I Photosensitizer with Aggregation-Induced Emission Characteristics for Tumor-Targeted Two-Photon Photodynamic Therapy

“…4,5 However, the prevalent use of PDT as a frontline treatment is generally confined to diseases that only occur in superficial biological tissues because of the firm oxygen reliance of PSs 6,7 and the limited penetration depth of the excitation light. 8,9 Therefore, it is generally believed that the application potential of PDT has not been fully revealed, and it is of great significance to explore advanced PSs that meet the requirements in deep tissue treatments.…”

“…Photodynamic therapy (PDT) is a medical procedure that involves the simultaneous utilization of light, photosensitizers (PSs), and oxygen to generate cytotoxic reactive oxygen species (ROS) to eradicate pathological cells. , Compared with conventional modalities, including surgery, chemotherapy, and radiotherapy, PDT has unique merits, such as minimal invasiveness, high spatiotemporal selectivity, low drug resistance, and easy operation, etc. , However, the prevalent use of PDT as a frontline treatment is generally confined to diseases that only occur in superficial biological tissues because of the firm oxygen reliance of PSs , and the limited penetration depth of the excitation light. , Therefore, it is generally believed that the application potential of PDT has not been fully revealed, and it is of great significance to explore advanced PSs that meet the requirements in deep tissue treatments.…”