Near-Infrared Light-Controllable Multifunction Mesoporous Polydopamine Nanocomposites for Promoting Infected Wound Healing

Abstract

The successful treatment of infected wounds requires strategies with effective antimicrobial, anti-inflammatory, and healing-promoting properties. Accordingly, the use of Cu 2+ and tetracycline (TC), which can promote angiogenesis, reepithelialization, and collagen deposition, also antibacterial activity, at the wound site, has shown application prospects in promoting infected wound repair. However, realizing controllable release to prolong action time and avoid potential toxicities is critical. Moreover, near-infrared light (NIR)-activated mesoporous polydopamine nanoparticles (MPDA NPs) reportedly exert antiinflammatory effects by eliminating the reactive oxygen species generated during inflammatory responses. In this study, we assess whether Cu 2+ and TC loaded in MPDA NPs can accelerate infected wound healing in mice. In particular, Cu 2+ is chelated and immobilized on the surface of MPDA NPs, while a thermosensitive phase-change material (PCM; melting point: 39−40 °C), combined with antibiotics, was loaded into the MPDA NPs as a gatekeeper (PPMD@Cu/TC). Results show that PPMD@Cu/TC exhibits significant great photothermal properties with NIR irradiation, which induces the release of Cu 2+ , while inducing PCM melting and, subsequent, TC release. In combination with anti-inflammatory therapy, NIR-triggered Cu 2+ and TC release enables the nanocomposite to eradicate bacterial wound infections and accelerate healing. Importantly, negligible damage to primary organs and satisfactory biocompatibility were observed in the murine model. Collectively, these findings highlight the therapeutic potential of this MPDA-based platform for controlling bacterial infection and accelerating wound healing.

Construction of Double-Shelled Hollow Ag2S@Polydopamine Nanocomposites for Fluorescence-Guided, Dual Stimuli-Responsive Drug Delivery and Photothermal Therapy

“…This provides a theoretical basis for their application in the field of NIR photothermal therapy. After coating with the PDA layer, the absorption intensity of HAg 2 S@HMPDA/LA is significantly increased due to strong NIR absorption of PDA [48]. In the spectrum of HAg 2 S@HMPDA/LA-DOX, a new broad absorption peak appears at 490 nm compared with HAg 2 S@HMPDA/LA nanocarriers, indicating the successful loading of the DOX drug.…”

Recent Development of Polydopamine Anti-Bacterial Nanomaterials

“…In addition, PDA-assisted Cu 2+ antibacterial materials can also be an option for wound healing. Zhang' group [78] prepared a nanocomposite material loaded with Cu 2+ and tetracycline in mesoporous PDA NPs, which prevented the uncontrolled release of Cu 2+ and TC and achieved the efficacy of efficient sterilization and promotion of wound healing (Figure 4c). PDA can also enhance antibacterial activity by combining with other metals.…”

“…For example, Xu and coworkers [68] firstly coated a , phase change materials and tetracycline(PPMD@Cu/TC). Reprinted with permission from [78] (copyright: American Chemical Society, 2022).…”

“…(c) Schematic diagram of polydopamine nanocomposites loaded with Cu 2+, phase change materials and tetracycline(PPMD@Cu/TC). Reprinted with permission from[78] (copyright: American Chemical Society, 2022).…”

Mesoporous polydopamine nanoparticles for sustained release of rapamycin and reactive oxygen species scavenging to synergistically accelerate neurogenesis after spinal cord injury

“…The antioxidant or anti-inflammation mechanism of PDA is to eliminate the generated reactive oxygen species (ROS). 26 Mesoporous polydopamine (mPDA) introduces an abundant mesoporous size cavity structure which offers matching sizes and large surface areas for many therapeutic agents, thus greatly increasing the drug loading capacity of a PDA-based delivery platform. 27 Kuthati et al developed mPDA for the delivery of morphine to treat neuropathic pain, with a drug loading efficiency of 50%.…”