Near-infrared light sensitive polypeptide block copolymer micelles for drug delivery

Multi-photon excitation in uncaging the small molecule bioregulator nitric oxide

“…The species shown in figure 4 use π -unsaturated aromatic compounds as the TPE chromophores, but it should be noted that metal complexes such as ruthenium amines have similarly been used as chromophores for TPE uncaging of neurotransmitters [46,51]. TPE has also been recently explored as a possible methodology for the targeted uncaging of cancer chemotherapy drugs [52][53][54] and antibacterials [54] as well as for ophthalmologic applications [55]. In one such example [54], the drugs of interest were encapsulated in water soluble micelles of a biocompatible block copolymer of poly(ethylene oxide) and a poly(Lglutamic acid) derivatized with coumarin dyes.…”

“…TPE has also been recently explored as a possible methodology for the targeted uncaging of cancer chemotherapy drugs [52][53][54] and antibacterials [54] as well as for ophthalmologic applications [55]. In one such example [54], the drugs of interest were encapsulated in water soluble micelles of a biocompatible block copolymer of poly(ethylene oxide) and a poly(Lglutamic acid) derivatized with coumarin dyes. TPE of these materials using 794 nm light led to dissociation of the dyes from the polypeptide and a shift of the hydrophilic-hydrophobic balance and destabilization of the micelles, leading in turn to release of the encapsulated drugs.…”

Fluorescent Dyes Used in Polymer Carriers as Imaging Agents in Anticancer Therapy

“…Furthermore, Miksa et al [198] prepared nanocapsules for 5-fluorouracil delivery decorated with a poly(2-ethylhexyl methacrylateco-7-(4-trifluoromethyl)coumarin acrylamide) cross-linked wall which fulfilled the versatile strategy of release drug combining a long shelflife with the ability for rapid release using external factors such as light ( Figure 26). In this case a monomer of 2-ethyhexyl methacrylate was used as a "linactant" -line active molecule that reduce the line tension thereby modulating the lipid bilayer membrane texture [254][255][256][257]. Zhao et al [257] reported the near-infrared light sensitive polypeptide block copolymer PEO114-b-P(LGA0.62-co-COU0.38)34 with coumarin moieties which self-assembled into micelles for drug delivery of an antibacterial Rifampicin and an anticancer Paclitaxel.…”

“…In this case a monomer of 2-ethyhexyl methacrylate was used as a "linactant" -line active molecule that reduce the line tension thereby modulating the lipid bilayer membrane texture [254][255][256][257]. Zhao et al [257] reported the near-infrared light sensitive polypeptide block copolymer PEO114-b-P(LGA0.62-co-COU0.38)34 with coumarin moieties which self-assembled into micelles for drug delivery of an antibacterial Rifampicin and an anticancer Paclitaxel. They studied the biocompatible block copolymer composed of poly(ethylene oxide) (PEO) and poly(L-glutamic acid) (PLGA) containing a number of 6-bromo-7-hydroxycoumarin-4-ylmethyl groups.…”

Triggered Copolypeptide Hydrogel Degradation Using Photolabile Lysine Protecting Groups

“…12 Postpolymerization conjugation of photoactive groups to polypeptide segments in block copolymers has been used by many groups to create micelles that can either photodegrade or photocrosslink. 13,14 Preparation of NCA monomers containing photoresponsive side-chain modifications has also been explored. While preparation of functional NCAs requires more synthetic effort up front, the ability to precisely incorporate these functional residues in a controlled polymerization provides advantages for preparation of well-defined materials.…”