“…TXA can be administered intravenously, intramuscularly, topically, orally and even nebulized. 12 Plasma levels of 10 mg/L have been reported to inhibit only 80 % of tPA activity, while a tenfold higher dose (100 mg/L) is required for 100 % inhibition. 2 Table 1 presents common dosing strategies in cardiac and non-cardiac surgeries.…”