Neck adipose tissue accumulation is associated with higher overall and central adiposity, a higher cardiometabolic risk, and a pro-inflammatory profile in young adults

Téllez, María José Arias; Acosta, Francisco M.; Garcia-Rivero, Yolanda; Pascual-Gamarra, José M.; Merchán-Ramírez, Elisa; Martínez-Téllez, Borja; Silva, Analiza M.; Almansa, Julio F.; Elvira, J.M. Llamas; Ruiz, Jonatan R.

doi:10.1038/s41366-020-00701-5

Cited by 15 publications

(19 citation statements)

References 74 publications

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“…29,30 13 Despite NC has been associated with higher upper body subcutaneous fat, a deposit of fat that includes neck adipose tissue, described as having an important contribution to the available systemic free fatty acids (more than central fat), and that some studies have shown NC as a good indicator of CMR cluster in children, adolescents and young adults, whether NC is associated with CMR in Chilean preschoolers, is unknown and should be explored in future studies. 11,12,15,17,[37][38][39][40]…”

Section: Discussionmentioning

confidence: 99%

“…[8][9][10] Likewise, neck adipose tissue, an ectopic depot of the upper body, has been associated with cardiometabolic risk (CMR) and inflammatory profile, independent of visceral adipose tissue mass in young people. 11,12 However, findings on neck adipose tissue in the pediatric population are still unknown. Neck circumference (NC) has been associated with adiposity indicators, such as BMI, WC, fat mass index, and/or visceral adipose tissue mass in children and adults.…”

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confidence: 99%

“…13,14 Indeed, NC has also been proposed as a useful surrogate tool of estimation of neck adipose tissue and CMR, especially in sedentary young men. 12 Recently, in children and adolescents, NC has also been identified as a potential predictor of early metabolic alterations. 13,15 At present, NC cut-offs have been used as a novel indicator to screen pediatric obesity in preschoolers, and CMR in children and adolescents.…”

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confidence: 99%

“…12,[31][32][33][34][35] Although there are no studies that associate NC with gold standard indicators of total and central fat mass in pediatric population, two studies have shown the association of NC with bio-electrical impedance analysis technique in children and adolescents 16. In this context, Bammann et al investigated 78 preschool/school children aged 4-10 years, from four different European countries, and showed that NC is not the best predictor of fat mass (unadjusted R 2 =0.484) 36.…”

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confidence: 99%

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Neck circumference cut-off points to determine obesity in Chilean preschool children

et al. 2022

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Background: The prevalence of obesity in Chilean preschoolers is high. Simple methods for the diagnosis in Chilean preschoolers are of public health interest. We determined neck circumference cut-off points as a proxy measure of obesity according to age and sex.Methods: 597 participants (267 girls) were included. NC, weight, height, and waist circumference were measured. Body mass index scores (BMI z scores) was calculated. Descriptive variables for girls and boys were compared with t-test. Pearson correlations were calculated to examine the relationship of NC with classical anthropometric measures. NC cut-off values (ROC analysis) and Kappa coefficient, were calculated.Results: NC was positively associated with BMI z score and WC among girls and boys, across age groups (all p<0.001). Obese cut-off points of NC for elevated BMI z score were between 25.3~25.9 cm in girls and 26.2 in boys, while those for WC were, 25.7 and 26.3 for 5-year-old girls and boys, respectively. The KC between BMI z score or WC with NC had an agreement strength between poor to moderate (all p<0.001).Conclusions: NC demonstrated to be a reliable indicator for the diagnosis of obesity for Chilean preschoolers. Future studies are needed to validate this finding.

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Neck circumference cut-off points to determine obesity in Chilean preschool children

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“…A growing body of evidence suggested that, similar to waist circumference (WC), NC also acted as a powerful tool in identifying metabolic syndrome, 1 , 2 assessing subclinical atherosclerosis, 3 screening for non-alcoholic fatty liver disease, 4 and predicting cardiovascular diseases effectively. 5 , 6 …”

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Association Between Neck Circumference and Microalbuminuria in Community Residents

Jian¹,

Xu²,

Shen³

et al. 2021

DMSO

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Objective Neck circumference (NC) represents the subcutaneous fat deposition in the neck and is an effective indicator for evaluating metabolic disorders, such as metabolic syndrome, subclinical atherosclerosis, and non-alcoholic fatty liver disease. Microalbuminuria (MAU) is regarded as a potential sign of systemic endothelial dysfunction and microvascular abnormalities. The aim of this study was to elucidate the association of NC with urine albumin-to-creatinine ratio (UACR) and MAU. Methods A total of 1882 Shanghai community residents were enrolled (816 men and 1066 women), with age ranging from 40 to 80 years. Anthropometric parameters, including NC, and biochemical indices were measured. MAU was determined if 30 mg/g ≤ UACR < 300 mg/g. An elevated NC was defined as NC ≥ 38.5 cm for men and NC ≥ 34.5 cm for women. Results Individuals with an elevated NC had significantly higher prevalence of MAU and UACR values than those with normal NC in both men and women (all P < 0.05). The logistic regression analysis showed that there were significant and positive associations between elevated NC and the increasing risk of MAU after adjusting for lipid profile and glycemic indices ( P = 0.007 for men and P = 0.009 for women). After further adjusting for blood pressure, elevated NC caused an 69.3% additional risk of MAU in men ( P = 0.037) and the positive correlation in women disappeared ( P = 0.131). Conclusion There was an independent and positive association between elevated NC and the risk of MAU in men in the Chinese community population. Chinese Clinical Trial Registry ( Www.chictr.org.cn ) Registration Number ChiCTR1900024011.

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Neck Fat Estimation from DXA Using Convolutional Neural Networks

Cresswell

Karpe

Basty

2022

Medical Image Understanding and Analysis

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Neck adipose tissue accumulation is associated with higher overall and central adiposity, a higher cardiometabolic risk, and a pro-inflammatory profile in young adults

Cited by 15 publications

References 74 publications

Neck circumference cut-off points to determine obesity in Chilean preschool children

Neck circumference cut-off points to determine obesity in Chilean preschool children

Association Between Neck Circumference and Microalbuminuria in Community Residents

Neck Fat Estimation from DXA Using Convolutional Neural Networks

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