Neck dissection field and lymph node density predict prognosis in patients with oral cavity cancer and pathological node metastases treated with adjuvant therapy

Liao, Chun‐Ta; Lee, Li‐Yu; Lin, Chien‐Yu; Fan, Kang‐Hsing; Wang, Hung‐Ming; Huang, Shiang‐Fu; Chen, I-How; Kang, Chung‐Jan; Ng, Shu‐Hang; Tsao, Chung‐Kan; Huang, Yu‐Chen; Yen, Tzu‐Chen

doi:10.1016/j.oraloncology.2011.10.017

Cited by 114 publications

(120 citation statements)

References 21 publications

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“…Furthermore, a number of studies have reported that LND may be used to predict the survival time of OSCC patients treated with different neck dissection procedures, such as unilateral or bilateral neck dissections (5-10). The present findings, demonstrating an association between LND and overall survival rate, are in concordance with this previous evidence (5)(6)(7)(8)(9)(10). With regard to head and neck cancer, numerous studies have reported an association between LND and overall survival in patients with OSCC (5-9).…”

Section: Overall Survival -------------------------------------------supporting

confidence: 92%

“…The LND determined by pathological examination has emerged as a prognostic parameter for various types of cancer, including bladder, esophageal and oral cancers (5)(6)(7)(8)(9)(10)(11)(12). The ratio of the LND weights three factors that may influence nodal staging: Tumor (the true number of positive Fisher's exact test.…”

Section: Discussionmentioning

confidence: 99%

“…The lymph node density (LND), which is calculated as the ratio of the number of positive lymph nodes to the number of total lymph nodes, has been found to reliably predict the survival of patients with oral squamous cell carcinoma (OSCC), bladder carcinoma and other carcinomas with positive neck lymph nodes in recent studies (5)(6)(7)(8)(9)(10)(11)(12). However, the association between the LND and overall survival in individuals with major salivary gland carcinoma has not yet been investigated.…”

Section: Introductionmentioning

confidence: 99%

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Lymph node density is a prognostic factor in patients with major salivary gland carcinoma

et al. 2015

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Abstract. Lymph node density (LND) has been reported to be a significant predictor of survival in patients with oral and other carcinomas exhibiting positive lymph nodes. The present study investigated whether the LND is associated with overall survival in subjects with major salivary gland carcinoma. A total of 78 patients newly diagnosed with major salivary gland carcinoma underwent primary tumor resection and neck dissection without preoperative treatment. Of these 78 patients, 32 with pathologically positive lymph nodes were enrolled in the present study. The LND was calculated as the ratio of the number of positive lymph nodes to the number of total lymph nodes. The survival rate was analyzed according to the Kaplan-Meier method. A univariate survival analysis was performed using the log-rank test, and a multivariate survival analysis was performed using the Cox proportional hazards model. An LND of ≥0.38 was found to significantly correlate with a shorter overall survival time in univariate analysis (P=0.017). In multivariate survival analysis, after adjusting for anatomical location (parotid gland/others), an LND of ≥0.38 was identified to be associated with a significantly shorter overall survival time. These results suggest that the LND functions as a prognostic factor in cases of major salivary gland carcinoma.

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Section: Overall Survival -------------------------------------------supporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Lymph node density is a prognostic factor in patients with major salivary gland carcinoma

et al. 2015

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“…Unlike other types of solid tumors, the metastasis of OSCCs mostly involves local invasion and often is restricted to the head and neck area. Cervical lymph node metastasis is a critical prognostic factor for OSCCs, the patients without such metastasis usually have higher survival rates (4)(5)(6). Like other cancers, oral cancer metastasis requires an extensive remodeling and degradation of extracellular matrix (ECM), in part, via increased expression of matrix metalloproteinases (MMP; ref.…”

Section: Introductionmentioning

confidence: 99%

miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

et al. 2014

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MicroRNAs offer tools to identify and treat invasive cancers. Using highly invasive isogenic oral squamous cell carcinoma (OSCC) cells, established using in vitro and in vivo selection protocols from poorly invasive parental cell populations, we used microarray expression analysis to identify a relative and specific decrease in miR-491-5p in invasive cells. Lower expression of miR-491-5p correlated with poor overall survival of patients with OSCCs. miR-491-5p overexpression in invasive OSCC cells suppressed their migratory behavior in vitro and lung metastatic behavior in vivo. We defined the G-protein-coupled receptor kinase-interacting protein 1 (GIT1)-as a direct target gene for miR-491-5p control. GIT1 overexpression was sufficient to rescue miR-491-5p-mediated inhibition of migration/invasion and lung metastasis. Conversely, GIT1 silencing phenocopied the ability of miR-491-5p to inhibit migration/invasion and metastasis of OSCC cells. Mechanistic investigations indicated that miR-491-5p overexpression or GIT1 attenuation reduced focal adhesions, with a concurrent decrease in steady-state levels of paxillin, phospho-paxillin, phospho-FAK, EGF/EGFR-mediated extracellular signal-regulated kinase (ERK1/2) activation, and MMP2/9 levels and activities. In clinical specimens of OSCCs, GIT1 levels were elevated relative to paired normal tissues and were correlated with lymph node metastasis, with expression levels of miR-491-5p and GIT1 correlated inversely in OSCCs, where they informed tumor grade. Together, our findings identify a functional axis for OSCC invasion that suggests miR-491-5p and GIT1 as biomarkers for prognosis in this cancer. Cancer Res; 74(3); 751-64. Ó2013 AACR.

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“…The control of cervical lymph node metastasis and identification of prognostic factors are important for improving the prognosis of OSCC patients. Previous studies have identified the following as prognostic factors of cervical lymph node metastasis: the number of lymph nodes affected by metastasis, 9 differentiation of the primary tumour, [16][17][18] contralateral cervical lymph node metastasis, 18 the number of lymph node metastases with ECS 19 , the field of metastasis, 19 and lymph node density. 19,20 The number of lymph node metastases with ECS and metastasis to the level IV or V field have been associated with a poor prognosis.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of the level of progression of extracapsular spread for cervical lymph node metastasis in oral squamous cell carcinoma

Yamada

Yanamoto

Otani

et al. 2016

International Journal of Oral and Maxillofacial Surgery

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Neck dissection field and lymph node density predict prognosis in patients with oral cavity cancer and pathological node metastases treated with adjuvant therapy

Cited by 114 publications

References 21 publications

Lymph node density is a prognostic factor in patients with major salivary gland carcinoma

Lymph node density is a prognostic factor in patients with major salivary gland carcinoma

miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis

Evaluation of the level of progression of extracapsular spread for cervical lymph node metastasis in oral squamous cell carcinoma

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