Necrospermia, antisperm antibodies, and vasectomy

Chávez-Badiola, Alejandro; Drakeley, Andrew J.; Finney, Victoria; Sajjad, Yasmin; Lewis‐Jones, D. I.

doi:10.1016/j.fertnstert.2007.04.007

Cited by 11 publications

(9 citation statements)

References 19 publications

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“…Exposure to Mycoplasma heat shock proteins, can significantly affect mucosal immune system by the release of cytokines (IFN-A, IL-10 and TNF-A) leading to severe immunopathological conditions associated with infertility. These results are observed in infertile women with infection while such an issue has not been reported in infected fertile women (33,34). This may be due to differences in the types of infertility in women (women with unexplained infertility in comparison with subfertile women in this study).…”

Section: Discussioncontrasting

confidence: 53%

The Effect of Infection With Genital Mycoplasma hominis and the Presence of Antisperm Antibodies in Iranian Women With Unexplained Infertility

Mana¹,

Farzaneh²,

Arash³

et al. 2016

IJWHR

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Section: Discussioncontrasting

confidence: 53%

The Effect of Infection With Genital Mycoplasma hominis and the Presence of Antisperm Antibodies in Iranian Women With Unexplained Infertility

Mana¹,

Farzaneh²,

Arash³

et al. 2016

IJWHR

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“…There was no evidence that antisperm antibodies are responsible for the damage to spermatogenesis in unilateral cases; however, measurement of the serum hormones showed elevations of LH and FSH which cannot be entirely explained as secondary to the damaged spermatogenesis. There was weak but nevertheless significant evidence that testis maldescent may be a poor prognostic factor as far as subsequent fertility [ 101 , 102 ].…”

Section: Discussionmentioning

confidence: 99%

Antioxidative effects of cerium dioxide nanoparticles ameliorate age-related male infertility: optimistic results in rats and the review of clinical clues for integrative concept of men health and fertility

et al. 2015

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BackgroundMale infertility has largely idiopathic, multifactorial origin. Oxidative stress is a major factor that affects spermatogenesis, in particular in aging. Cerium dioxide nanoparticles (CNPs) due to their antioxidative properties are promising to impact on the development of male infertility. The aims of this study were to investigate the effects of CNPs on fertility parameters in 24-month male rats and to overview relevant literature in the field of personalized treatments, predictive diagnosis, and preventive measures for male health and fertility.MethodsWe included 30 24-month-old male rats. After a week of adaptation to the standard diet, the rats were randomly divided into three groups with ten rats in each. Group 1 (controls) received only a standard diet. The rats of group 2 and 3 in adjunct to the standard diet during 10 days received intragastrically 10 % sodium citrate and citrate-coated CNPs in dose 1 mg/kg, respectively. We assessed sex hormones, epididymal sperm parameters and spermatogenesis, ultrasound, and morphological data of rat reproductive organs.ResultsAfter a 10-day administration of CNPs, we revealed significant decrease of lipid peroxidation product levels in serum and increase of catalase and SOD activity, associated with increase of sperm count (p < 0.001) and improvement in quantitative sperm parameters (motility, viability, and percentage of spermatozoa). We found no significant changes between sperm quantitative parameters in citrate-treated rats and controls and observed age-related decrease of activated Leydig cell number and focal atrophy of the seminiferous tubules. In CNP group, we observed regeneration of seminiferous tubules, increase number and activation of Leydig cells, and 2.5-fold significant increase of serum testosterone. Ultrasound data showed the slight increase of linear measurement and volume of rat testes in CNP group. Review highlights the benefits for predictive diagnosis, preventive measures, and personalized approaches to manage male infertility in the general concept of male health also related to aging.ConclusionCitrate-coated 2–5-nm CNPs lead to increase in sex hormones levels, sperm count, and quality, as well as the activation of spermatogenesis in 24-month-old male rats. Nanoceria demonstrated the perspectives to be an effective infertility treatment via reduction of oxidative stress in male reproductive organs, in particular in aging.

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“…Necrospermia is indicated in many etiologies, including chronic or acute medical conditions, infections [84], severe exposure to pollutants [85], and epididymal necrospermia [86], among others. Sperm degeneration and death may occur during the epididymal passage or storage time, or because of biochemical components present in seminal plasma during ejaculation [87]. Chavez–Badiola et al attempted to successfully retrieve active sperm from necrospermic patients with ASAs following vasectomy reversal procedures [87].…”

Section: Role Of Antisperm Antibodies In Infertilitymentioning

confidence: 99%

“…Sperm degeneration and death may occur during the epididymal passage or storage time, or because of biochemical components present in seminal plasma during ejaculation [87]. Chavez–Badiola et al attempted to successfully retrieve active sperm from necrospermic patients with ASAs following vasectomy reversal procedures [87]. ASAs are said to be produced locally in the epididymis.…”

Section: Role Of Antisperm Antibodies In Infertilitymentioning

confidence: 99%

Role of Antisperm Antibodies in Infertility, Pregnancy, and Potential for Contraceptive and Antifertility Vaccine Designs: Research Progress and Pioneering Vision

Vickram

Dhama

Chakraborty³

et al. 2019

Vaccines

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Sperm of humans, non-human primates, and other mammalian subjects is considered to be antigenic. The effect of changes in autoimmunity on reproductive cells such as spermatozoa and oocytes play a critical but indistinct role in fertility. Antisperm antibodies (ASAs) are invariably present in both females and males. However, the degree of ASA occurrence may vary according to individual and gender. Although the extent of infertility due to ASAs alone is yet to be determined, it has been found in almost 9–12% of patients who are infertile due to different causes. Postcoital presence of spermatozoa in the reproductive tract of women is not a contributory factor in ASA generation. However, ASA generation may be induced by trauma to the vaginal mucosa, or by anal or oral sex resulting in the deposition of sperm inside the digestive tract. It is strongly believed that, in humans and other species, at least some antibodies may bind to sperm antigens, causing infertility. This form of infertility is termed as immunological infertility, which may be accompanied by impairment of fertility, even in individuals with normozoospermia. Researchers target ASAs for two major reasons: (i) to elucidate the association between ASAs and infertility, the reason ASAs causes infertility, and the mechanism underlying ASA-mediated infertility; and (ii) to assess the potential of ASAs as a contraceptive in humans in case ASAs influences infertility. Therefore, this review explores the potential application of ASAs in the development of anti-spermatozoa vaccines for contraceptive purposes. The usefulness of ASAs for diagnosing obstructive azoospermia, salpingitis, and oligoasthenoteratozoospermia has been reviewed extensively. Important patents pertaining to potential candidates for spermatozoa-derived vaccines that may be utilized as contraceptives are discussed in depth. Antifertility vaccines, as well as treatments for ASA-related infertility, are also highlighted. This review will address many unresolved issues regarding mechanisms involving ASAs in the diagnosis, as well as prognoses, of male infertility. More documented scientific reports are cited to support the mechanisms underlying the potential role of ASA in infertility. The usefulness of sperm antigens or ASAs (recombinant) in human and wild or captive animal contraceptive vaccines has been revealed through research but is yet to be validated via clinical testing.

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Necrospermia, antisperm antibodies, and vasectomy

Cited by 11 publications

References 19 publications

The Effect of Infection With Genital Mycoplasma hominis and the Presence of Antisperm Antibodies in Iranian Women With Unexplained Infertility

The Effect of Infection With Genital Mycoplasma hominis and the Presence of Antisperm Antibodies in Iranian Women With Unexplained Infertility

Antioxidative effects of cerium dioxide nanoparticles ameliorate age-related male infertility: optimistic results in rats and the review of clinical clues for integrative concept of men health and fertility

Role of Antisperm Antibodies in Infertility, Pregnancy, and Potential for Contraceptive and Antifertility Vaccine Designs: Research Progress and Pioneering Vision

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