Necrostatin-1 as a Neuroprotectant

Necrostatin-1: a promising compound for neurological disorders

“…Several types of cell death, including apoptosis, autophagy-induced cell death, and necrosis, have been implicated in PD progression. In PD models, Necrostatin-1 prevents rotenone-induced necroptosis by affecting mitochondrial morphology ( Alegre-Cortés et al, 2020 ) and exerts a protective effect on dopaminergic neurons by decreasing the expression of cathepsin B and increasing the expression of Bcl-2 ( Wu et al, 2015 ; Jantas and Lasoń, 2022 ).…”

“…In the Al-induced AD model, Necrostatin-1 enhances acetylcholine (ACh) levels and downregulates the expression of AD-related genes and proteins ( Gao X. et al, 2022 ). Furthermore, Necrostatin-1 inhibits neural cell degeneration and alleviates learning and memory deficits ( Qinli et al, 2013 ; Jantas and Lasoń, 2022 ). Postoperative cognitive dysfunction (POCD) has become a prevalent complication in the elderly population.…”

“…Mechanistically, necroptosis is a significant cause of cell death after SAH. Necrostatin-1 attenuates early brain injury after SAH by inhibiting necroptosis ( Chen et al, 2017 ; Jantas and Lasoń, 2022 ). Another study suggested that Necrostatin-1 plays a neuroprotective role by inhibiting apoptosis and autophagy pathways in the SAH model ( Chang et al, 2014 ).…”

“…Necrostatin-1 has a protective effect on the endoplasmic reticulum by inhibiting the expression of ERS-related genes and proteins, such as C/EBP homologous protein (CHOP), immunoglobulin-binding protein (BiP/GRP78), and X-box-binding protein-1 (XBP-1) ( Wang et al, 2017 ). Moreover, Necrostatin-1 improves mitochondrial functions in SCI ( Jantas and Lasoń, 2022 ). It decreases Ca 2+ concentration, increases adenosine triphosphate (ATP) generation, inhibits cytochrome c release, and preserves the mitochondrial membrane potential (MMP) level ( Wang et al, 2015 ).…”