Necrotic pulmonary nodules in secondary syphilis

McCready, Janine; Skrastins, Roland; Downey, James F.; Powis, Jeff

doi:10.1503/cmaj.091479

Cited by 16 publications

(8 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Proposed by Coleman et al in 1983, clinical criteria for diagnosing pulmonary involvement in secondary syphilis are: (1) presence of history and clinical findings consistent with secondary syphilis; (2) pulmonary abnormalities on X-ray with or without pulmonary symptoms or signs; (3) positive serological tests for syphilis; (4) exclusion of other pulmonary diseases, when possible, using bacilloscopy, serological tests, cultures, and cytological examination of sputum; and (5) therapeutic response to treatment 8 . Clinical and radiological responses to penicillin confirm pulmonary syphilis and may help exclude differential diagnoses 7,9 . Reportedly, lung lesions respond well to treatment, and imaging findings are resolved in weeks or around six months 2 .…”

Section: Discussionmentioning

confidence: 92%

Secondary syphilis with pulmonary involvement mimicking lymphoma: a case report

Florencio

Costa

Viana

et al. 2019

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

We present a case of atypical presentation of secondary syphilis with extensive lymph node involvement and pulmonary lesions, initially suspected as lymphoma. The patient presented with weight loss, dry cough, chest pain, palpable lymph nodes in several peripheral chains, and multiple pulmonary nodules and masses on chest imaging. The key features for secondary syphilis diagnosis were a lymph node biopsy suggestive of reactive lymphadenopathy, positive serologic tests for syphilis, and complete recovery after antisyphilitic treatment.

show abstract

Section: Discussionmentioning

confidence: 92%

Secondary syphilis with pulmonary involvement mimicking lymphoma: a case report

Florencio

Costa

Viana

et al. 2019

Rev. Soc. Bras. Med. Trop.

View full text Add to dashboard Cite

show abstract

“…A literature review by David et al 2 in 2006 reported only nine cases of pulmonary syphilis in 37 years ; however, 12 cases were reported in the subsequent eight years. [2][3][4][5][6][7][8][9][10][11][12][13][14] Although a worldwide increase in syphilis incidence was reported in the 2000s, it is still lower than the incidence observed from the 1970s to the 1990s; therefore, the increasing number of cases of pulmonary syphilis is likely not due to the relatively higher syphilis incidence reported recently.…”

Section: Discussionmentioning

confidence: 99%

“…Interestingly, multiple subpleural nodules were found in all of chest CT scans. [2][3][4][5][6][7][8][9][10][11][12][13][14] reported that no specific lesion could be identified in their literature review. However, recent case reports reveal that multiple subpleural nodules (typically located in the lower lobes) are considered one of the prominent features of pulmonary syphilis.…”

Section: Discussionmentioning

confidence: 99%

“…They are frequently accompanied by chest (or sometimes epigastric) pain. 2,[7][8][9][10][11][12] In the four published cases of pulmonary syphilis (including ours), PCR or immunohistochemistry of respiratory samples tested positive for syphilis. 2,3,14 Buffet et al 15 suggested that both PCR and immunohistochemistry are reliable diagnostic tools for syphilis with comparably high levels of sensitivity and specificity.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Pulmonary involvement of secondary syphilis

et al. 2017

View full text Add to dashboard Cite

Pulmonary involvement in secondary syphilis is considered a rare occurrence; however, the number of cases has increased in the 2000s. This is likely due to the increased use of computed tomography scans and molecular diagnostic testing. We report a case of an HIV-positive man with pleural chest pain and bilateral subpleural nodules on chest computed tomography. His rapid plasma reagin and Treponema pallidum hemagglutination tests were positive, and the specimen of one of the pulmonary nodules obtained by transthoracic biopsy was positive for the polA gene of Treponema pallidum. Since clinical manifestations of syphilis are highly variable, clinicians should bear in mind that pleural chest pain with bilateral subpleural nodules can be caused by pulmonary syphilis.

show abstract

“…La sintomatología de la SS pulmonar suele ser inespecífica y a menudo subclínica, siendo el dolor torá cico y la tos seca los síntomas má s comunes 3 pacientes es la presencia en la mitad de los casos de una hepatitis, a menudo colestá sica, lo que corrobora el cará cter sisté mico de la infecció n. El patró n radioló gico muestra, en la mayoría de los casos, nó dulos pulmonares, por lo general mú ltiples, aunque tambié n se han descrito masas, infiltrados intersticiales y derrame pleural 3,4 . Nuestra observació n clínica es el segundo caso descrito de lesió n seudotumoral 8 .…”

unclassified