Necrotizing enterocolitis in low birth weight infants in China: Mortality risk factors expressed by birth weight categories

Tian, Qing; Zhang, Rong; Zhu, Li; Shi, Peng; Yang, Jie; Yang, Changyi; Chen, Dongmei; Shi, Jingyun; Zhou, Xiaoguang; Qiu, Yinping; Yong, Yang; He, Ling; He, Shijun; Cao, Yun-tao; Wei, Qiufen; Kumar, Manoj; Chen, Chao

doi:10.1016/j.pedneo.2016.10.004

Cited by 47 publications

(36 citation statements)

References 29 publications

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“…Multiple studies were also reported from the Europe including Poland, Romania, Finland, Belgium, Sweden and Switzerland [12,13,23,39,42,43]. Also, four studies were done in China, Korea, Singapore and Malaysia [14,16,44,45]. Three studies from Australia [4,21,46], one from the Middle East [7] and one from India [24].…”

Section: Study Characteristicsmentioning

confidence: 99%

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Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis

2020

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Background: Necrotizing Enterocolitis (NEC) is a major cause of morbidity and mortality in the Neonatal Intensive Care Unit (NICU), yet the global incidence of NEC has not been systematically evaluated. We conducted a systematic review and meta-analysis of cohort studies reporting the incidence of NEC in infants with Very Low Birth Weight (VLBW). Methods: The databases searched included PubMed, MEDLINE, the Cochrane Library, EMBASE and grey literature. Eligible studies were cohort or population-based studies of newborns including registry data reporting incidence of NEC. Incidence were pooled using Random Effect Models (REM), in the presence of substantial heterogeneity. Additional, bias adjusted Quality Effect Models (QEM) were used to get sensitivity estimates. Subgroup analysis and meta-regression were used to explore the sources of heterogeneity. Funnel plots as appropriate for ratio measures were used to assess publication bias. Results: A systematic and comprehensive search of databases identified 27 cohort studies reporting the incidence of NEC. The number of neonate included in these studies was 574,692. Of this 39,965 developed NEC. There were substantial heterogeneity between studies (I 2 = 100%). The pooled estimate of NEC based on REM was 7.0% (95% CI: 6.0-8.0%). QEM based estimate (6.0%; 95% CI: 4.0-9.0%) were also similar. Funnel plots showed no evidence of publication bias. Although, NEC estimates are similar across various regions, some variation between high and low income countries were noted. Meta regression findings showed a statistically significant increase of NEC over time, quantified by the publication year. Conclusion: Seven out of 100 of all VLBW infants in NICU are likely to develop NEC. However, there were considerable heterogeneity between studies. High quality studies assessing incidence of NEC along with associated risk factors are warranted.

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Section: Study Characteristicsmentioning

confidence: 99%

“…Qian et al reported data extracted retrospectively from 95 major referral centers and hospitals in china covering a large area of 29 provinces [44]. VLBW infants were specified and the incidence of NEC according to Bell's criteria was presented in 2011.…”

Section: Qualitative Reviewmentioning

confidence: 99%

Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis

2020

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“…Multiple studies were also reported from the Europe including Poland, Romania, Finland, Belgium, Sweden and Switzerland (12,13,28,(32)(33)(34). Also, four studies were done in China, Korea, Singapore and Malaysia (14,16,35,36). Three studies from Australia (4,37,38), one from the Middle East (7) and one from India (42).…”

Section: Study Characteristicsmentioning

confidence: 99%

Global Incidence of Necrotizing Enterocolitis: a Systematic Review and Incidence Meta-Analysis

Alsaied¹,

Islam²,

Thalib³

2020

Preprint

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Background: Necrotizing Enterocolitis (NEC) is a major source of morbidity and mortality in the Neonatal Intensive Care Unit (NICU), yet the global incidence is not systematically evaluated. We conducted a systematic review and Meta-Analysis of cohort studies reporting the incidence of NEC in infants with Very Low Birth Weight (VLBW).Methods: The databases searched included PubMed, MEDLINE, the Cochrane Library, EMBASE and grey literature. Eligible studies were cohort or population-based studies of newborns including registry data reporting incidence of NEC. Data were extracted from the selected papers and variables extracted included author and publication details, time period covered by the study, location and setting of the study and whether it was VLBW infants or preterm infants, incidence or number on NEC cases and size of population at risk were extracted from the selected papers. Additionally, risk of bias assessment of the included studies were carried out using a validated tool. Bias adjusted Quality Effect Model (QEM) were used to pool the estimates. Due to substantial heterogeneity, Random Effect Model (REM) estimates were also evaluated. The heterogeneity between studies were evaluated using the Cochrane Q statistics and Higgin’s I2 value. Subgroup analysis and meta-regression were used to explore the sources of heterogeneity. Funnel plots as appropriate for ratio measures were used to assess publication bias.Results: A systematic and comprehensive search of databases identified 27 cohort studies reporting the incidence of NEC. The pooled estimate of the global incidence of NEC was 6.0% (95% CI: 4.0%-9.0%). There were substantial heterogeneity (I2 = 100%) between studies. Funnel plots showed no evidence of publication bias.Conclusion: The incidence of NEC vary considerably, although meta-regression failed provide evidence for any substantial regional variation. High quality studies along with detailed risk factors of NEC is warranted, to predict and NEC.

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“…Also, four studies were done in China, Korea, Singapore and Malaysia (14,16,35,36). Three studies from Australia (4,37,38), one from the Middle East (7) and one from India (42).…”

Section: Study Characteristicsmentioning

confidence: 99%

Global Incidence of Necrotizing Enterocolitis: a Systematic Review and Meta-Analysis

Alsaied

Islam

Thalib

2020

Preprint

View full text Add to dashboard Cite

Background: Necrotizing Enterocolitis (NEC) is a major cause of morbidity and mortality in the Neonatal Intensive Care Unit (NICU), yet the global incidence of NEC has not been systematically evaluated. We conducted a systematic review and meta-analysis of cohort studies reporting the incidence of NEC in infants with Very Low Birth Weight (VLBW).Methods: The databases searched included PubMed, MEDLINE, the Cochrane Library, EMBASE and grey literature. Eligible studies were cohort or population-based studies of newborns including registry data reporting incidence of NEC. Data were extracted from the selected papers included incidence of NEC cases and size of population at risk, author and publication details, follow up period covered by the study, location and setting of the study and whether it was VLBW infants or preterm infants. Additionally, risk of bias assessment of the included studies were carried out using a validated tool. Bias adjusted Quality Effect Model (QEM) were used to pool the estimates. In the presence of substantial heterogeneity, Random Effect Models (REM) were used as an additionally sensitivity analyses. The heterogeneity between studies were evaluated using the Cochrane Q statistics and Higgin’s I2 value. Subgroup analysis and meta-regression were used to explore the sources of heterogeneity. Funnel plots as appropriate for ratio measures were used to assess publication bias. Results: A systematic and comprehensive search of databases identified 27 cohort studies reporting the incidence of NEC. The pooled estimate of the global incidence of NEC was 6.0% (95% CI: 4.0%-9.0%). There were substantial heterogeneity (I2 = 100%) between studies. Funnel plots showed no evidence of publication bias.Conclusion: Seven out of 100 of all VLBW infants in NICU are likely to develop NEC. However, there were considerable heterogeneity between studies. High quality studies assessing incidence of NEC along with associated risk factors are warranted.

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Necrotizing enterocolitis in low birth weight infants in China: Mortality risk factors expressed by birth weight categories

Cited by 47 publications

References 29 publications

Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis

Global incidence of Necrotizing Enterocolitis: a systematic review and Meta-analysis

Global Incidence of Necrotizing Enterocolitis: a Systematic Review and Incidence Meta-Analysis

Global Incidence of Necrotizing Enterocolitis: a Systematic Review and Meta-Analysis

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