Necrotizing Fasciitis

Fustes‐Morales, A.; Gutiérrez‐Castrellón, Pedro; Durán‐McKinster, Carola; Orozco‐Covarrubias, Luz; Tamayo‐Sánchez, Lourdes; Ruíz-Maldonado, Ramón

doi:10.1001/archderm.138.7.893

Cited by 150 publications

(39 citation statements)

References 63 publications

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“…The diagnosis of NF in its early stages is not always possible and can be confused with simple skin infections such as cellulitis [17]. The most common sites for NF are the abdomen, upper limbs, lower limbs, and perineum [18].…”

Section: Introductionmentioning

confidence: 99%

Pyoderma Gangrenosum Simulating Necrotizing Fasciitis

Souza

Silva

Santos

et al. 2015

Case Reports in Medicine

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Pyoderma gangrenosum received this name due to the notion that this disease was related to infections caused by bacteria in the genus Streptococcus. In contrast to this initial assumption, today the disease is thought to have an autoimmune origin. Necrotizing fasciitis was first mentioned around the fifth century AD, being referred to as a complication of erysipelas. It is a disease characterized by severe, rapidly progressing soft tissue infection, which causes necrosis of the subcutaneous tissue and the fascia. On the third day of hospitalization after antecubital venipuncture, a 59-year-old woman presented an erythematous and painful pustular lesion that quickly evolved into extensive ulceration circumvented by an erythematous halo and accompanied by toxemia. One of the proposed etiologies was necrotizing fasciitis. The microbiological results were all negative, while the histopathological analysis showed epidermal necrosis and inflammatory infiltrate composed predominantly of dermal neutrophils. Pyoderma gangrenosum was considered as a diagnosis. After 30 days, the patient was discharged with oral prednisone (60 mg/day), and the patient had complete healing of the initial injury in less than two months. This case was an unexpected event in the course of the hospitalization which was diagnosed as pyoderma gangrenosum associated with myelodysplastic syndrome.

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Section: Introductionmentioning

confidence: 99%

Pyoderma Gangrenosum Simulating Necrotizing Fasciitis

Souza

Silva

Santos

et al. 2015

Case Reports in Medicine

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“…For the pediatric patient cohort, type 2 infections seem to be more frequent 2. Knowing the possible pathogens, patients should receive broad-spectrum IV antibiotics to cover streptococci, staphylococci, gram negative rods, and anaerobes 8. Clindamycin should be considered since it can switch off exotoxin production and inhibit M protein synthesis, thus promoting phagocytosis and suppressing the effects of bacterial toxins in mediating septic shock 9.…”

Section: Discussionmentioning

confidence: 99%

Pediatric Necrotizing Fasciitis: Restitutio Ad Integrum after Early Diagnosis and Aggressive Surgical Treatment

Lemaréchal

Zundel

Szavay

2016

European J Pediatr Surg Rep

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“…In 2001, Johnston et al 10 presented 7 cases of NF associated with chemotherapy-induced neutropenia treated with broad-spectrum intravenous antibiotics, urgent surgical intervention and HOT therapy. In 2002, Fustes-Morales et al 11 reported 39 children with NF treated with HOT as adjuvant therapy. Just 3 of 39 had ALL as underlying factor.…”

Section: Discussionmentioning

confidence: 99%

“…3–11 To date, standard regimens, used for adults for the treatment of various diseases, are not available in children and it is fairly obvious that every child requires an individualized treatment. Therefore, the application of HOT therapy in this age group requires, beside the knowledge of the basic principles that regulate HOT, also a close collaboration between the different specialists involved in the care of the child.…”

Section: Introductionmentioning

confidence: 99%

Hyperbaric oxygen treatment of superficial soft tissue lesions in children with oncologic disease

et al. 2011

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This study aimed to assess the feasibility and results of hyperbaric oxygen therapy (HOT) as supportive treatment of lesions of superficial soft tissues in children with oncological diseases. This was a retrospective analysis and review of all records of children observed at the Pediatric Hematology-Oncology Department of the University of Padova and treated adjuvantly with HOT. Between 1996 and 2010, 12 patients (5 males and 7 females, median age 7 years, range 0.5–16) underwent HOT. The effectiveness of HOT varied according to the lesion treated. Ten out of 12 patients were cured. Efficacy was most questionable in 2 patients with skin graft and flaps at risk. Compliance to therapy was close to 100%. In just one case, HOT was interrupted for the appearance of local skin metastases close to the site of primary tumor. HOT showed itself to be safe and effective in most patients even those immunocompromised or critically ill.

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Necrotizing Fasciitis

Cited by 150 publications

References 63 publications

Pyoderma Gangrenosum Simulating Necrotizing Fasciitis

Pyoderma Gangrenosum Simulating Necrotizing Fasciitis

Pediatric Necrotizing Fasciitis: Restitutio Ad Integrum after Early Diagnosis and Aggressive Surgical Treatment

Hyperbaric oxygen treatment of superficial soft tissue lesions in children with oncologic disease

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