Necrotizing pneumonia caused Staphylococcus aureus

Abstract

Necrotizing pneumonia caused by S. aureus is infrequent, but very serious illness with a high mortality. Pneumonia arises mainly in children and young adults, develops within several days is accompanied with multiple necroses in lung tissue, often leads to a lethal outcome. The feature ofpathogen is ability to formation ofpore-forming toxin destroying different cells in the body including polymorphonuclear leukocytes. The previous virus infection, for example flu, is considered a contributing factor or the co-infection which creates prerequisites for destruction ofneutrophils in lungs with appearance ofnecroses. S. aureus is not the most frequent causative agent of community-acquired pneumonia therefore empirical therapy does not include antibiotics with the activity against staphylococci which are sensitive or resistant to oxacyllin/meticyllin. As a result empirical regimen of antibacterial therapy appears not to be effective. Early clinical signs are a high fever, blood in the sputum, the presence of cavities in the lungs, a rapid increase in respiratory failure. The microscopy of sputum with detection o a large number of staphylococci allows to establish pathogen at an early stage, before obtaining results oif microbiological tests to prove application ofantibiotics active against staphylococci, and after receiving microbiological data to carry out the final correction ovf antibacterial therapy. Respiratory virus infection preceding peumonia or adverse epidemiological situation (flu epidemic) also is the justification for empiric application of anti-staphylococcal antibiotics in community acquired pneumonia.

Clinical and radiological variants of lung damage in the infection caused by staphylococcus aureus

“…Возможно слияние очагов, которое не принимает характера обширной инфильтрации. При пневмонии контуры очагов менее четкие изза преобладания экссудативного воспалительного компонента, что отличается ее от бронхиолита [38]. Важным симптомом бронхогенного процесса можно рассматривать наличие патологического содержимого в просвете бронхов, что представлено слизистым или гнойным содержимым (рис.…”