Necrotizing Tracheitis Secondary to Corynebacterium Species Presenting With Central Airway Obstruction

Guerrero, Jorge; Mallur, Pavan S.; Folch, Erik; Keyes, Colleen; Stillman, Isaac E.; Gangadharan, Sidhu P.; Majid, Adnan

doi:10.4187/respcare.02150

Cited by 10 publications

(15 citation statements)

References 13 publications

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“…Another study reported that healthy human skin is colonized with macrolide, lincosamide and streptogramin B resistance (MLS B )carrying resistance genes (erm (A), erm (B), erm (C), erm (X), lin (A), msr (A) and mph (C)) [40]. Isolated and confirmed reports recently of bacteremia in a leukaemia patient caused by a multi-drug resistant strain (C resistens DSM 45100), bacteremia in an infant on vancomycin therapy caused by C falsenii and pseudomembranous nectrotizing tracheitis secondary to Corynebacterium species should be considered as an alarming bell for recognizing NDC's as potential pathogens [41,42,43]. Recently there are increasing reports of novel species of Corynebacteria which in future may be associated with human infections [44].…”

Section: Recent Trendsmentioning

confidence: 60%

Non Diphtheritic Corynebacteria (NDC) and Their Clinical Significance: Clinical Microbiologist’s Perspective

Ramana¹,

Vikram²,

PadmaWali³

et al. 2014

AJEID

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Aerobic, Gram positive, catalase positive and non-spore forming bacilli, which are morphologically similar to Corynebacterium diphtheriae are described as either diphtheroids or coryneform bacteria, resembling C diphtheriae. Corynebacteria are a group of bacteria placed under the family corynebacteriaceae, which come under the phylum, Actinobacteria. Among the members of genus Corynebacterium, only C diphtheriae is considered as a pathogen but other species are present either as normal flora in human or as saprophytes in the environment and have rarely been associated with human infections. Of late, there have been increased reports of both new species of genus Corynebacterium and their occurrence in various human infections. It is now imperative that clinical microbiologists and clinicians understand the potential role of NDC in human infections. Only few studies globally have characterized the human clinical isolates of NDC and their antimicrobial susceptibility patterns. This review tries toexamine? the potential pathogenic nature of NDC, which warrants their identification and prompt reporting when isolated from human clinical specimens.

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Section: Recent Trendsmentioning

confidence: 60%

Non Diphtheritic Corynebacteria (NDC) and Their Clinical Significance: Clinical Microbiologist’s Perspective

Ramana¹,

Vikram²,

PadmaWali³

et al. 2014

AJEID

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“…were described in the literature. They presented as mild airway erythema, circumferential ulcerations, pseudomembranous plaque-like lesions, and severe obstruction of the trachea (28,29,122).…”

Section: Bronchoscopic Findings In Bacterial Caoimentioning

confidence: 99%

Infections causing central airway obstruction: role of bronchoscopy in diagnosis and management

Keshishyan¹,

DeLorenzo²,

Hammoud³

et al. 2017

J. Thorac. Dis.

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Central airway obstructive infections (CAOI) are challenging medical conditions that may represent an advanced and complicated process of ongoing infections. The epidemiology of CAOI is unknown as well as the pathophysiology and the mechanism of development. This is due to sparse data in the literature that consists mainly of case reports and retrospective case series. CAOI can be caused by fungal, bacterial, parasitic and viral infections. Most patients with CAOI can be diagnosed clinically and with chest imaging, which demonstrate obstruction of the central airways. However, bronchoscopy is commonly used to confirm and obtain a specific diagnosis to guide specific therapy. In recent years, interventional pulmonology (IP) is becoming widely available and offer a minimally invasive approach for the management of central airway diseases such as cancers, benign strictures, and other conditions. Various bronchoscopic modalities are used to treat central airway obstruction (CAO), such as mechanical debulking, endobronchial laser therapy, electrocautery, argon plasma coagulation, cryotherapy, and airway stenting. In patients with CAOI, the role of therapeutic bronchoscopy is not clearly defined, but many isolated reports in the literature described bronchoscopic intervention in combination with medical therapy as the initial management approach. In this paper, we present cases of CAOI that underwent bronchoscopic intervention as part of their management. We described the infectious etiology, locations, bronchoscopic findings and bronchoscopic modalities for airway management.

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“…Another corynebacterium, Corynebacterium pseudodiphtheriticum, has been responsible for necrotizing tracheitis [61].…”

Section: Other Bacteriamentioning

confidence: 99%

Update on childhood and adult infectious tracheitis

Blot

Bonniaud-Blot²,

Favrolt

et al. 2017

Médecine et Maladies Infectieuses

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The trachea is a pivotal organ of the respiratory tract. Rather than a genuine anatomic border, it acts as a crossroad in all respiratory infectious processes. Even though not strictly limited to the trachea, infections such as laryngotracheitis and tracheobronchitis are frequently diagnosed in children, in particular during the winter season. Infectious tracheitis etiologies are diverse and the distinction between viral and bacterial origins, albeit difficult, remains relevant considering the substantial differences in terms of gravity and therapeutic management. This literature review summarizes the microbiological and clinical aspects of community-acquired and nosocomial tracheitis in adults and children, as well as the adequate diagnostic and therapeutic approaches. It also highlights the emergence of fungal tracheitis in immunocompromised patients, of ventilator-associated tracheitis in intensive care medicine, and beyond all that the potential short and long-term consequences of tracheitis.

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Necrotizing Tracheitis Secondary to Corynebacterium Species Presenting With Central Airway Obstruction

Cited by 10 publications

References 13 publications

Non Diphtheritic Corynebacteria (NDC) and Their Clinical Significance: Clinical Microbiologist’s Perspective

Non Diphtheritic Corynebacteria (NDC) and Their Clinical Significance: Clinical Microbiologist’s Perspective

Infections causing central airway obstruction: role of bronchoscopy in diagnosis and management

Update on childhood and adult infectious tracheitis

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