Needle tract seeding and malignant transformation of hepatocellular adenoma into well‐differentiated hepatocellular carcinoma in a dog

Jornet‐Rius, Oriol; Agulla, Beatriz; López, María Cristina; Viñeta, Claudia; García‐Ferrer, Alicia; Serrano, Bárbara; Marco, Alberto; Palomares, Anna; Novellas, Rosa; Espada, Yvonne; Roura, Xavier; Solano‐Gallego, Laia

doi:10.1111/vcp.13221

Cited by 2 publications

(1 citation statement)

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“…A recent study revealed that canine HCA transforms into HCC, which means recurrence may occur [56]. Therefore, this study demonstrated that Y RNA has a high potential for distinguishing canine HCA from HCC.…”

Section: Discussionmentioning

confidence: 60%

Novel Y RNA-Derived Fragments Can Differentiate Canine Hepatocellular Carcinoma from Hepatocellular Adenoma

Ushio,

Hasan,

Arif

et al. 2023

Animals

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Hepatocellular carcinomas (HCC) are common tumors, whereas hepatocellular adenomas (HCA) are rare, benign tumors in dogs. The aberrant expression of noncoding RNAs (ncRNAs) plays a pivotal role in HCC tumorigenesis and progression. Among ncRNAs, micro RNAs have been widely researched in human HCC, but much less widely in canine HCC. However, Y RNA-derived fragments have yet to be investigated in canine HCC and HCA. This study targeted canine HCC and HCA patients. We used qRT-PCR to determine Y RNA expression in clinical tissues, plasma, and plasma extracellular vesicles, and two HCC cell lines (95-1044 and AZACH). Y RNA was significantly decreased in tissue, plasma, and plasma extracellular vesicles for canine HCC versus canine HCA and healthy controls. Y RNA was decreased in 95-1044 and AZACH cells versus normal liver tissue and in AZACH versus 95-1044 cells. In plasma samples, Y RNA levels were decreased in HCC versus HCA and Healthy controls and increased in HCA versus Healthy controls. Receiver operating characteristic analysis showed that Y RNA could be a promising biomarker for distinguishing HCC from HCA and healthy controls. Overall, the dysregulated expression of Y RNA can distinguish canine HCC from HCA. However, further research is necessary to elucidate the underlying Y RNA-related molecular mechanisms in hepatocellular neoplastic diseases. To the best of our knowledge, this is the first report on the relative expression of Y RNA in canine HCC and HCA.

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Section: Discussionmentioning

confidence: 60%