Negative affectivity moderated by BDNF and stress response

Perea, Claudia S.; Paternina, A.C.; Gómez, Yvonne; Lattig, María Claudia

doi:10.1016/j.jad.2011.09.043

Cited by 33 publications

(30 citation statements)

References 56 publications

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“…In early life it regulates neuronal development and activity that could result in varying behavioral outcomes (Perea et al, 2012). Later in life it is involved in the survival and differentiation of the central nervous system (Dechant and Neumann, 2002;Lipsky and Marini, 2007;Waterhouse and Xu, 2009).…”

Section: Brain-derived Neurotrophic Factormentioning

confidence: 99%

“…Investigations of the interaction between physical and psychological childhood maltreatment and the Val/Met polymorphism demonstrated that affected individuals carrying a Met allele scored higher in adult depressive symptoms compared to those with the Val/Val genotype (Aguilera et al, 2009;Gatt et al, 2009;Perea et al, 2012). However, Gatt and colleagues proposed that both the Val and the Met allele, respectively, can confer risk to symptoms of mental disorders when a subject is exposed to childhood stress.…”

Section: Bdnf In Relation To Chronic (Occupational) Stress and Burnoutmentioning

confidence: 99%

See 1 more Smart Citation

A biological perspective on differences and similarities between burnout and depression

Orosz

Federspiel²,

Haisch

et al. 2017

Neuroscience & Biobehavioral Reviews

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Section: Brain-derived Neurotrophic Factormentioning

confidence: 99%

Section: Bdnf In Relation To Chronic (Occupational) Stress and Burnoutmentioning

confidence: 99%

A biological perspective on differences and similarities between burnout and depression

Orosz

Federspiel²,

Haisch

et al. 2017

Neuroscience & Biobehavioral Reviews

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“…In all, 16 studies explored the interaction between childhood adversity and BDNF in depression, 4 reported a significant effect [73,74,76,77] and 5 showed partial support for this interaction [65][66][67][68]78] (see Table 3). For instance, rather than investigating child adversity as one overarching construct, Aguilera and colleagues [66] focused on different types and only found a significant interaction between child sexual abuse and BDNF.…”

Section: Childhood Adversitymentioning

confidence: 99%

“…It is possible that the BDNF × stress in depression is only relevant to Caucasian populations, although significant interactions have been reported among Asian [43] and ethnically mixed populations [76,77]. Future studies need to recruit participants from non-Caucasian backgrounds to test the generalisability of the BDNF × stress in depression to other ethnic groups.…”

Section: Limitationsmentioning

confidence: 99%

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Interaction between stress and the BDNF Val66Met polymorphism in depression: A systematic review and meta-analysis

Hosang¹,

Shiles²,

McGuffin³

et al. 2014

Comprehensive Psychiatry

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Background: Major depression is a disabling psychiatric illness with complex origins. Life stress (childhood adversity and recent stressful events) is a robust risk factor for depression. The relationship between life stress and Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) gene has received much attention. The aim of the present work was to review and conduct a meta-analysis on the results from published studies examining this interaction. Methods: A literature search was conducted using PsychINFO and PubMed databases until 22 November 2013. A total of 22 studies with a pooled total of 14,233 participants met the inclusion criteria, the results of which were combined and a meta-analysis performed using the Liptak-Stouffer z-score method. Results: The results suggest that the Met allele of BDNF Val66Met significantly moderates the relationship between life stress and depression (P = 0.03). When the studies were stratified by type of environmental stressor, the evidence was stronger for an interaction with stressful life events (P = 0.01) and weaker for interaction of BDNF Val66Met with childhood adversity (P = 0.051). Conclusions:The interaction between BDNF and life stress in depression is stronger for stressful life events rather than childhood adversity. Methodological limitations of existing studies include poor measurement of life stress.

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Genetic association of the transcription of neuroplasticity‐related genes and variation in stress‐coping style

et al. 2015

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IntroductionStress coping has been defined as the cognitive and behavioral efforts made to conquer, endure, or decrease external and internal demands and the conflicts between them. It has two main elements: the control or modification of the person–environment relationship causing the stress (i.e., problem-focused coping) and/or regulation of stressful feelings (i.e., emotion-focused coping). Research suggests that the expressions of brain-derived neurotrophic factor (BDNF) and neurotrophic tyrosine kinase receptor type 2 (NTRK2) play important roles in brain adaptation to investigate stress. To clarify the genetic basis of stress coping, we investigated the association of stress-coping strategies and social adaptation with single-nucleotide polymorphisms (SNPs) involved in neural plasticity, anxiety, and depression.MethodsIn 252 healthy controls (94 women; 158 men), we measured and estimated the stress-coping style using the Lazarus-type stress-coping inventory, ego aptitude scale (EAS), and social adaptation self-evaluation scale (SASS). We investigated one SNP of BDNF (rs6265, Val/Met) and five SNPs of NTRK2 (rs11140800, rs1187286, rs1867283, rs1147198, and rs10868235).ResultsWe observed significant associations between BDNF and emotion-focused strategies, seeking social support, self-control, and distancing. We also found significant associations between NTRK2 and cognitive strategies, problem-solving, confrontive- coping, seeking social support, distancing and positive reappraisal. Significant associations were also found between BDNF and critical attitudes and between NTRK2 and all seven ego-related factors on the EAS. In the SASS, the minor allele rs1867283 of NTRK2 had a significantly higher score than the heterozygote.ConclusionsThese findings may provide insights into the partial effects of genetic mutations in BDNF and NTRK2 on stress tolerance and personality.

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Negative affectivity moderated by BDNF and stress response

Cited by 33 publications

References 56 publications

A biological perspective on differences and similarities between burnout and depression

A biological perspective on differences and similarities between burnout and depression

Interaction between stress and the BDNF Val66Met polymorphism in depression: A systematic review and meta-analysis

Genetic association of the transcription of neuroplasticity‐related genes and variation in stress‐coping style

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