Negative allergy study in a case of postorgasmic illness syndrome (POIS)

Depreux, Nathalie; Basagaña, María; Pascal, Mariona

doi:10.1016/j.androl.2017.06.002

Cited by 8 publications

(13 citation statements)

References 7 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In contrast to these hypotheses, Depreux et al had negative results on immunoblotting and western blot of their POIS patient’s autologous semen [12].…”

Section: Resultsmentioning

confidence: 99%

“…Sexual function interview focusing on ejaculatory disorders and the relationship with the partner should be recorded. The duration of symptoms must be well noted since it is an essential factor of the thorough history in making differential diagnosis [2, 7, 12, 23].…”

Section: Resultsmentioning

confidence: 99%

“…Careful physical exam needs to be done, including a digital rectal examination (DRE) after a midstream urine sample has been collected for urine dipstick, microscopic analysis and culture [2, 7, 12, 23].…”

Section: Resultsmentioning

confidence: 99%

“…Patients should undergo routine tests, including full blood count, serum electrolytes and creatinine, liver function tests and hormonal check (follicle stimulating hormone, luteinizing hormone, prolactin, and testosterone) [2, 4, 6, 7, 12].…”

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Post orgasmic illness syndrome: what do we know till now?

Abdessater

Elias

Mikhael³

et al. 2019

Basic Clin. Androl.

View full text Add to dashboard Cite

Background Peri orgasmic dysfunctions are very rare and little information exists on their diagnosis and treatment. One of these conditions is post-orgasmic illness syndrome (POIS), manifesting by a debilitating cluster of symptoms affecting men within seconds, minutes, or hours after ejaculation. The aim of this article is to do a thorough literature review about POIS, in order to elucidate the pathophysiology, the diagnosis and the management of this rare disease. Results Updated literature review on Pubmed was done, using the following terms: “orgasm illness”, “post-orgasmic” and “postorgasmic illness syndrome”. The references of the 17 identified publications were also reviewed for additional 8 relevant articles that were all included in the results. POIS has 5 preliminary diagnostic criteria and criterion 1 has 7 described clusters. Pathophysiological hypotheses include: immunological phenomenon (most relevant), opioid-like withdrawal, neuroendocrine response, transient deregulation of the autonomic nervous system, hypersensitivity and disordered cytokines. Differential diagnoses include: chronic prostatitis, orgasmolepsy, benign orgasmic cephalgia, sneezing and rhinorrhea, postcoital dysphoria, post-coital asthma and rhinitis. Patients have been symptomatically treated with antihistamines, non-steroidal anti-inflammatory drugs, selective serotonin reuptake inhibitors, and benzodiazepines. A trial of hyposensitization therapy with autologous semen was successful. Conclusion POIS is a rare condition that is underdiagnosed, most probably because of its unclear pathophysiology leading to a lack of treatment options. Further studies are warranted to investigate the prevalence, pathophysiology, and management of this debilitating condition.

show abstract

“…In contrast to these hypotheses, Depreux et al had negative results on immunoblotting and western blot of their POIS patient’s autologous semen [12].…”

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 2 more Smart Citations

Post orgasmic illness syndrome: what do we know till now?

Abdessater

Elias

Mikhael³

et al. 2019

Basic Clin. Androl.

View full text Add to dashboard Cite

show abstract

“…The patients with POIS should undergo a complete medical history that includes existing allergies, sexually transmitted diseases, and any history of prostatitis. In addition, a neuropsychiatric interview regarding possible neurological or psychiatric disorders, as well as a sexual function interview with special attention to ejaculatory disorders and their partner relationship should both be recorded 2,3,16,18 . Patients should be carefully examined and screened for other diseases that have similar symptoms to POIS.…”

Section: Clinical Presentationmentioning

confidence: 99%

Postorgasmic Illness Syndrome: What do we know so far?

Le¹,

Nguyen²,

Hellstrom³

2018

J Rare Dis Res Treat

View full text Add to dashboard Cite

Post-orgasmic illness syndrome (POIS) is rare condition that is characterized by transient flu-like symptoms and cognition disorders that occur shortly after ejaculation and last for 2-7 days. There are about 50 cases of POIS in the literature. The prevalence and incidence of POIS are still unknown due to a paucity of studies. The exact pathogenesis of POIS remains unknown; the most acceptable hypothesis is an autoimmune/allergic process. We made a literature search via PubMed for publications from 2002 to 2018 with the "post orgasmic illness syndrome" medical subject heading term to analyze current data regarding symptoms, burden, pathophysiology, and to discuss potential management options for POIS. POIS is diagnosed by five preliminary diagnostic criteria. It is categorized into two types: primary and secondary. There is the concomitance between POIS and PE. The autoimmune/allergy hypothesis is the most accepted hypothesis explaining POIS pathogenesis. A competing hypothesis involves a disorder of endogenous μ-opioid receptors. Patients with POIS have been symptomatically treated with antihistamines, selective serotonin reuptake inhibitors, and benzodiazepines. A trial of hyposensitization therapy with autologous semen was successful. A trial of nonsteroidal anti-inflammatory medication helped in a single case report but failed to successfully treat other patients with POIS.

show abstract