Negative epistasis: a route to intraspecific reproductive isolation in yeast?

Hou, Jing; Schacherer, Joseph

doi:10.1007/s00294-015-0505-y

Cited by 13 publications

(11 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The search for signs of hybrid speciation in very large populations, for example yeast, will be an exciting avenue for hybrid speciation research in the future (see e.g., [ 53 ]). That is because, firstly, multiple DMIs, both inter- and intraspecific, have been identified in yeast [ 30 , 54 , 55 ]. In addition, yeast can be easily maintained in the lab and lends itself to powerful experimental approaches.…”

Section: Discussionmentioning

confidence: 99%

In search of the Goldilocks zone for hybrid speciation

Blanckaert

Bank

2018

PLoS Genet

View full text Add to dashboard Cite

Hybridization has recently gained considerable interest both as a unique opportunity for observing speciation mechanisms and as a potential engine for speciation. The latter remains a controversial topic. It was recently hypothesized that the reciprocal sorting of genetic incompatibilities from parental species could result in hybrid speciation, when the hybrid population maintains a mixed combination of the parental incompatibilities that prevents further gene exchange with both parental populations. However, the specifics of the purging/sorting process of multiple incompatibilities have not been examined theoretically. We here investigate the allele-frequency dynamics of an isolated hybrid population that results from a single hybridization event. Using models of two or four loci, we investigate the fate of one or two genetic incompatibilities of the Dobzhansky-Muller type (DMIs). We study how various parameters affect both the sorting/purging of the DMIs and the probability of observing hybrid speciation by reciprocal sorting. We find that the probability of hybrid speciation is strongly dependent on the linkage architecture (i.e. the order and recombination rate between loci along chromosomes), the population size of the hybrid population, and the initial relative contributions of the parental populations to the hybrid population. We identify a Goldilocks zone for specific linkage architectures and intermediate recombination rates, in which hybrid speciation becomes highly probable. Whereas an equal contribution of parental populations to the hybrid population maximizes the hybrid speciation probability in the Goldilocks zone, other linkage architectures yield unintuitive asymmetric maxima. We provide an explanation for this pattern, and discuss our results both with respect to the best conditions for observing hybrid speciation in nature and their implications regarding patterns of introgression in hybrid zones.

show abstract

Section: Discussionmentioning

confidence: 99%

In search of the Goldilocks zone for hybrid speciation

Blanckaert

Bank

2018

PLoS Genet

View full text Add to dashboard Cite

show abstract

“…Identifying the molecular mechanisms underlying reproductive isolation would allow us to deduce the driving force of speciation. Yeasts have proven to be an excellent model organism for studying postzygotic isolation, helping to demonstrate the involvement of anti‐recombination induced by DNA sequence divergence, chromosomal rearrangements, and genetic incompatibility . Apart from DNA sequence divergence, which can occur simply by mutation accumulation, development of postzygotic isolation is often deemed a by‐product of adaptive selection .…”

Section: Introductionmentioning

confidence: 99%

Mitochondrial–nuclear co‐evolution leads to hybrid incompatibility through pentatricopeptide repeat proteins

2016

View full text Add to dashboard Cite

Mitochondrial-nuclear incompatibility has a major role in reproductive isolation between species. However, the underlying mechanism and driving force of mitochondrial-nuclear incompatibility remain elusive. Here, we report a pentatricopeptide repeatcontaining (PPR) protein, Ccm1, and its interacting partner, 15S rRNA, to be involved in hybrid incompatibility between two yeast species, Saccharomyces cerevisiae and Saccharomyces bayanus. S. bayanus-Ccm1 has reduced binding affinity for S. cerevisiae-15S rRNA, leading to respiratory defects in hybrid cells. This incompatibility can be rescued by single mutations on several individual PPR motifs, demonstrating the highly evolvable nature of PPR proteins. When we examined other PPR proteins in the closely related Saccharomyces sensu stricto yeasts, about two-thirds of them showed detectable incompatibility. Our results suggest that fast co-evolution between flexible PPR proteins and their mitochondrial RNA substrates may be a common driving force in the development of mitochondrial-nuclear hybrid incompatibility.

show abstract

“…Inability to undergo meiosis and to complete a sexual cycle is a common feature of hybrids (Hunter et al 1996;Wolfe 2015), including intra-species ones (Hou and Schacherer 2016;Rogers et al 2018).…”

Section: Discussionmentioning

confidence: 99%

Genomic evidence for a hybrid origin of the yeast opportunistic pathogenCandida albicans

Mixão

Gabaldón

2019

Preprint

View full text Add to dashboard Cite

AbstractOpportunistic yeast pathogens are of increasing medical concern. Candida albicans, the species with the highest incidence, is a natural commensal of humans that can adopt a pathogenic behaviour. This species is highly heterozygous, is an obligate diploid, and cannot undergo meiosis, adopting instead a parasexual cycle. The origin of these traits is unknown and we hypothesize they could result from ancestral hybridization. We tested this idea by analyzing available genomes of C. albicans isolates and comparing them to those of hybrid and non-hybrid strains of other Candida species. Our results show compelling evidence that C. albicans is an evolved hybrid, with levels and patterns of ancestral heterozygosity that cannot be fully explained under the paradigm of vertical evolution. Although the level of inferred divergence between the putative parental lineages (2.8%) is not clearly beyond current species boundaries in Saccharomycotina, we show here that all analyzed C. albicans strains derive from a single hybrid ancestor, which diverged by extensive loss of heterozygosis. This finding has important implications for our understanding of C. albicans evolution, including the loss of the sexual cycle, the origin of the association with humans, and the evolution of virulence traits.

show abstract

Negative epistasis: a route to intraspecific reproductive isolation in yeast?

Cited by 13 publications

References 30 publications

In search of the Goldilocks zone for hybrid speciation

In search of the Goldilocks zone for hybrid speciation

Mitochondrial–nuclear co‐evolution leads to hybrid incompatibility through pentatricopeptide repeat proteins

Genomic evidence for a hybrid origin of the yeast opportunistic pathogenCandida albicans

Contact Info

Product

Resources

About