Negative pressure wound therapy (NPWT) on closed incisions to prevent surgical site infection in high-risk patients in hepatopancreatobiliary surgery: study protocol for a randomized controlled trial—the NP-SSI trial

Abstract

Background Incisional surgical site infections (iSSI) in hepatopancreatobiliary (HPB) surgery usually lead to prolonged hospital stays, consume valuable resources, and impact on patients’ outcome. Prophylactic closed incision negative pressure wound therapy (ciNPWT) to decrease wound complications has become available. Owing to an increasing number of studies, evidence for superiority in many indication areas has accumulated; however, in general surgery, there are a few data and those have shown contradictory results. Methods In this monocentric, prospective, randomized, controlled, two-armed study, the influence of ciNPWT on incisional surgical site infection rates after HPB operations will be investigated. A total of 222 patients will be randomized 1:1 to an interventional group (7-day treatment with ciNPWT) or a control group (treated with gauze dressing). The primary parameter to evaluate efficacy is the rate of incisional SSIs within 30 days after surgery. Additionally, several clinically relevant secondary outcomes will be assessed. Discussion A reduction in the rate of incisional SSIs would not only lead to a significant cost reduction and shorter postoperative length of stay, but may also improve postoperative quality of life for patients. While earlier publications have shown advantages for ciNPWT, recent studies did not confirm a positive effect regarding iSSI rate. Even if iSSI rate is not reduced, findings obtained from the secondary endpoints may be of clinical relevance, such as reduction of wound complication rates. Trial registration This trial has been registered in the German Clinical Trials Register, DRKS 00015136. Registered on 19 February 2019 and has been approved by the local ethics committee of the University of Regensburg: 18-1225-101.

Vacuum Therapy in Complex Treatment of Purulent-Necrotic Diseases of Soft Tissues: Clinical Cases

“…Лечение гнойных ран под вакуумной повязкой, или VAC-терапия (vacuum-assisted closure therapy), является одним из современных методов лечения ран, который имеет несколько преимуществ: это сокращение времени заживления раны, поскольку VAC-терапия создает благоприятные условия для естественного заживления тканей за счет улучшения микроциркуляции; снижение риска инфицирования, так как обеспечивается плотное прилегание повязки к коже и создается вакуум, ускоряющий эвакуацию из раны отделяемого и бактерий; уменьшение болевых ощущений за счет снижения натяжения лигатур; улучшение качества жизни пациента за счет более быстрой медико-социальной реабилитации с хоро-шим функциональным и косметическим эффектом. В целом VAC-терапия является эффективным и безопасным методом лечения гнойных ран, который имеет несколько преимуществ по сравнению с традиционными методами лечения [15][16][17][18][19].…”