Negishi Cross‐Coupling

Abstract

The palladium or nickel‐catalyzed coupling between an aryl or alkenylzinc, zirconium or aluminum reagent and an alkenyl or aryl halide or triflate; specifically, it is an organozinc reagent‐mediated coupling with an alkenyl or aryl halides/triflates and is generally known as the Negishi cross‐coupling. This reaction can tolerate a variety of functional groups and commonly catalyzed by a transition metal of palladium or nickel with triaryl or trialkyl phosphines as ligands. It has also been observed that the ligand has a substantial impact on the course of the Negishi cross‐coupling. This reaction has been modified for various conditions and is applied for the formation of C‐C bonds.