Neglected tropical disease (NTD) diagnostics: current development and operations to advance control

Oyeyemi, Oyetunde T.; Ogundahunsi, Olumide; Schunk, Mirjam; Fatem, Ramzy G.; Shollenberger, Lisa M.

doi:10.1080/20477724.2023.2272095

Pathogens and Global Health

2023

DOI: 10.1080/20477724.2023.2272095

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Neglected tropical disease (NTD) diagnostics: current development and operations to advance control

Oyetunde T. Oyeyemi,

Olumide Ogundahunsi,

Mirjam Schunk

et al.

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2024

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Cited by 2 publications

References 193 publications

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Leveraging wastewater-based epidemiology to monitor the spread of neglected tropical diseases in African communities

Ofori,

Agoha,

Bokoe

et al. 2024

Infectious Diseases

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Leveraging wastewater-based epidemiology to monitor the spread of neglected tropical diseases in African communities

Ofori,

Agoha,

Bokoe

et al. 2024

Infectious Diseases

View full text Add to dashboard Cite

Fasciola worm and egg-derived antigens: Exploring their diagnostic potential for urogenital schistosomiasis in resource-limited endemic regions

Adesida,

Oriade,

Sulaiman

et al. 2024

Asian Pacific Journal of Tropical Medicine

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Objective: To evaluate the immunodiagnostic potential of crude Fasciola gigantica-worm (FWA) and egg antigen (FEA) in detecting anti-Schistosoma (S.) haematobium antibodies in sera and urine samples. Methods: This is a cross-sectional diagnostic study. Employing an indirect ELISA, antibodies against these antigens were assessed in samples from infected and non-infected individuals in both schistosomiasis endemic (NE) and non-endemic (NNE) areas, using microscopy as the diagnostic standard. Results: FWA-sera exhibited excellent diagnostic accuracy with an area under the curve (AUC) of 0.957, a sensitivity of 93.75%, and a specificity of 85.42% for discriminating between infected and non-infected individuals in non-endemic areas. FWA-urine also demonstrated robust performance, achieving AUC>0.95, sensitivity>97.0%, and specificity>85.0% in both NE and NNE categories. Notably, S. haematobium-specific antibody levels against FWA were significantly elevated in infected individuals in both endemic and non-endemic areas. FEA-sera exhibited outstanding diagnostic performance with sensitivity exceeding 90% and an AUC of 0.968 in non-endemic samples but not in FEA-urine. Conclusions: FWA-based ELISAs, applicable to both sera and urine, emerge as promising tools for S. haematobium diagnosis in resource-limited settings, offering advantages of high sensitivity and specificity with shared antigens with Fasciola. The superior diagnostic metrics of urine samples suggest their potential as a noninvasive biological sample for diagnostic purposes.

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Neglected tropical disease (NTD) diagnostics: current development and operations to advance control

Cited by 2 publications

References 193 publications

Leveraging wastewater-based epidemiology to monitor the spread of neglected tropical diseases in African communities

Leveraging wastewater-based epidemiology to monitor the spread of neglected tropical diseases in African communities

Fasciola worm and egg-derived antigens: Exploring their diagnostic potential for urogenital schistosomiasis in resource-limited endemic regions

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