Nek5 interacts with mitochondrial proteins and interferes negatively in mitochondrial mediated cell death and respiration

Novel RNA biomarkers of prostate cancer revealed by RNA-seq analysis of formalin-fixed samples obtained from Russian patients

“…Expression pattern of the first one, NIMA related kinase 5 (NEK5), is poorly characterized at the moment. It belongs to the family of NEK kinases and is known to participate in cell cycle progression [19] and, as has recently been shown, in the regulation of mitochondrial mediated cell death [20]. The next two genes: KCNG36, encoding the subunit of potassium voltage-gated channel, and PTPRT, encoding tyrosine phosphatase, had not been associated with PCa previously.…”

Nek5 Association with Mitochondria Proteins and Functions: Is It a Nek Family characteristic?

“…Furthermore, Nek1 depleted cells from homozygous kat2J mice (lacking Nek1 expression) presented exacerbated mitochondrial membrane permeability (MMP) and consequently high levels of cell death [6,7]. In cells depleted for Nek5 we showed a tendency also for the cells to be more prone to ROS formation and cell death [5]. In addition, some articles suggest that the depletion of NEK2 sensitizes HeLa cells to apoptosis [8] and in combination with Paclitaxel and doxorubicin, Nek2 siRNA promote breast cancer cell apoptosis [9].…”

“…Three mitochondrial proteins: metaxin-2 (MTX2), BCL2-associated transcription factor 1 (BCLAF1) and cytochrome C oxidase assembly protein 11 (COX11) were identified raising the possibility that Nek5 is involved in the regulation of mitochondrial functions [5].…”

Epidermal growth factor-induced stimulation of proliferation and gene expression changes in the hypotrichous ciliate, Stylonychia lemnae

“…Up-regulation of UBE1 in the current study indicates that EGF may play a role in the maintenance of complex physiological and biochemical activities of the cell. Nek5 is known to be involved in cellular processes such as pre-gene expression, mRNA processing and rearrangement of ribonucleoprotein complexes (Melo Hanchuk et al, 2015). Melo Hanchuk et al suggested that human Nek5 can act as an anti-cell death protein, indicated by its inhibition of thapsigarginpromoted apoptosis (Melo Hanchuk et al, 2015).…”

“…Nek5 is known to be involved in cellular processes such as pre-gene expression, mRNA processing and rearrangement of ribonucleoprotein complexes (Melo Hanchuk et al, 2015). Melo Hanchuk et al suggested that human Nek5 can act as an anti-cell death protein, indicated by its inhibition of thapsigarginpromoted apoptosis (Melo Hanchuk et al, 2015). Nek7, another member of Nek family, is involved in microtubule-dependent transportation or microtubule stability (Cohen et al, 2013).…”