NEMA NU 2-2007 performance measurements of the Siemens Inveon™ preclinical small animal PET system

Abstract

National Electrical Manufacturers Association (NEMA) NU 2-2007 performance measurements were conducted on the Inveon ™ preclinical small animal PET system developed by Siemens Medical Solutions. The scanner uses 1.51 × 1.51 × 10 mm LSO crystals grouped in 20 × 20 blocks; a tapered light guide couples the LSO crystals of a block to a position-sensitive photomultiplier tube. There are 80 rings with 320 crystals per ring and the ring diameter is 161 mm. The transaxial and axial fields of view (FOVs) are 100 and 127 mm, respectively. The scanner can be docked to a CT scanner; the performance characteristics of the CT component are not included herein. Performance measurements of spatial resolution, sensitivity, scatter fraction and count rate performance were obtained for different energy windows and coincidence timing window widths. For brevity, the results described here are for an energy window of 350-650 keV and a coincidence timing window of 3.43 ns. The spatial resolution at the center of the transaxial and axial FOVs was 1.56, 1.62 and 2.12 mm in the tangential, radial and axial directions, respectively, and the system sensitivity was 36.2 cps kBq −1 for a line source (7.2% for a point source). For mouse-and rat-sized phantoms, the scatter fraction was 5.7% and 14.6%, respectively. The peak noise equivalent count rate with a noisy randoms estimate was 1475 kcps at 130 MBq for the mouse-sized phantom and 583 kcps at 74 MBq for the rat-sized phantom. The performance measurements indicate that the Inveon ™ PET scanner is a high-resolution tomograph with excellent sensitivity that is capable of imaging at a high count rate.

Evaluation of Small-Animal PET Outcome Measures to Detect Disease Modification Induced by BACE Inhibition in a Transgenic Mouse Model of Alzheimer Disease

“…The core body temperature was maintained by flowing heated air through the imaging cell. PET imaging was performed using an Inveon PET/CT scanner (Siemens Preclinical Solutions) (23). The scanner uses 1.59 · 1.59 · 10 mm lutetium oxyorthosilicate crystals grouped into blocks of 20 · 20 crystals.…”

Bone Marrow Stromal Cell Transplantation Enhances Recovery of Local Glucose Metabolism After Cerebral Infarction in Rats: A Serial 18F-FDG PET Study

“…The PET component consists of 1.5 · 1.5 · 10 mm lutetium oxyorthosilicate crystal elements with a ring diameter of 16.1 cm, providing a 10-cm transaxial and a 12.7-cm axial field of view (27)(28)(29).…”

PeneloPET, a Monte Carlo PET simulation tool based on PENELOPE: features and validation

“…The simulation included all the materials in the line source in order to take into account attenuation effects at the source. The sensitivity obtained for the line source activity was converted to equivalent sensitivity for a centered point source, as explained in Kemp et al (2006). The sensitivity estimated from real measurements by Kemp et al (2006) was 52.0 cps kBq −1 .…”

“…The sensitivity estimated from the simulations was 52.7 cps kBq −1 , in good agreement with the real measurements. Kemp et al (2006). Total coincidence rates and true, scatter and random counts contribution are also shown for the simulation.…”

“…A line source filled with FDG is introduced in the hole and an acquisition with an energy window from 350 to 650 keV is performed. This simulation mimics the setup described by Kemp et al (2006) to measure the INVEON NECR curve. We have taken the acquisition performance parameters (time and energy coincidence window, etc) according to the values quoted by Kemp et al (2006).…”