Neoadjuvant chemotherapy for primary sarcoma of the breast: a case report

Abstract

Background Primary sarcoma of the breast is rare. Surgery has been the only curative treatment available. Recently, neoadjuvant chemotherapy including anthracycline/ifosfamide has been reported effective for patients with high-risk sarcomas in a prospective trial. Case presentation A 52-year-old Japanese woman presented with a mass in her left breast. The 10 cm tumor was fixed to her chest wall on examination. A skin biopsy was performed which showed leiomyosarcoma. Neoadjuvant chemotherapy was given and the tumor became mobile. A mastectomy and axillary dissection were performed with surgically negative margins. After neoadjuvant chemotherapy, the amount of necrosis was profoundly influenced by chemotherapy, and the histological effect of neoadjuvant chemotherapy was assessed in reference to pre-neoadjuvant chemotherapy magnetic resonance imaging. Conclusion In contrast to many other cancers, the evaluation of various treatments and of the histological effect of neoadjuvant chemotherapy for sarcoma has been difficult due to the rarity of these tumors. We report the case of a patient with a breast sarcoma, treated with neoadjuvant chemotherapy and discuss the appropriate pathological evaluation and therapeutic management.

Peripheral Neural Sheath Breast Sarcoma: Case Report and Literature Review

“…The most common finding on mammography is a single, oval, hyperdense mass with indistinguishable or circumscribed margins with or without calcifications or spiculated lesions [ 2 , 4 , 11 ].…”

“…Malignant peripheral nerve sheath tumors (MPNSTs) have similarities with other primary breast sarcomas making diagnosis difficult, unsuspected and misdiagnosed without high clinical suspicion and inmunohistochemistry [ 1 ]. Evaluation includes a physical examination, breast images (mammography/ultrasound/nuclear magnetic resonance), extension studies (usually chest and abdominal tomography), and histological characterization associated with immunohistochemistry due to a wide variety of presentations [ 2 , 3 ].…”

Potential of combination of DCE-MRI and DWI with serum CA125 and CA199 in evaluating effectiveness of neoadjuvant chemotherapy in breast cancer

“…Neoadjuvant chemotherapy is often used as an adjuvant intervention in the clinical treatment of breast cancer patients [ 12 , 13 ]. Before tumour resection or local chemoradiotherapy, the use of neoadjuvant chemotherapy reduces the lesion volume to a certain extent, and prevents the spread of cancer cells, resulting in a positive effect on subsequent treatments [ 14 , 15 ].…”

Rabdomiossarcoma Mamário Bilateral Em Adolescente: Um Relato De Caso

“…O rabdomiossarcoma mamário primário bilateral é extremamente raro, dentre todas as neoplasias mamárias o sarcoma da mama é responsável por apenas 0,0006% dos cânceres de mama (MIYAZAKI et al, 2019). Somado a isso, apenas de 2 a 11% de todos os pacientes com câncer de mama, de qualquer tipo histológico, desenvolverão o câncer bilateralmente (HOMSI et al, 2019).…”