Neonatal Brain Abscess due to Extended-Spectrum Beta-Lactamase Producing Klebsiella pneumoniae

Biswas, Biswajit; Mondal, Monojit; Thapa, Rajoo; Mallick, Debkrishna; Datta, Anuja

doi:10.7860/jcdr/2014/10160.5198

Cited by 5 publications

(5 citation statements)

References 4 publications

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“…However, asymptomatic maternal urinary tract infection during pregnancy and nosocomial bacterial colonization during the neonate's hospital stay remain noteworthy measures to improve antenatal, intrapartum and delivery care, and greater measures during NICU hospitalization events are necessary to lower the overall risk of nosocomial infections [10], such as the case multidrug resistant K. pneumoniae diagnosed in the first day of life in this study. Empirical Carbapenems and/or Aminoglycoside coverage in neonates with K. pneumoniae sepsis and meningitis, especially in areas with a high rate of Extended Spectrum Beta-lactamases (ESBL) producing bacteria may be warranted [11].…”

Section: Discussionmentioning

confidence: 99%

Bacterial Meningitis Profile in Newborns: Is the Epidemiology Changing?

Bennaoui¹,

Slitine²,

Cissé³

et al. 2018

TOIDJ

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Objective: The aim of the study was to determine the epidemiological characteristics of bacterial meningitis observed in neonates. Materials and Methods: A retrospective study of all cases of meningitis, hospitalized in the neonatal intensive care unit, Mohamed VI University Hospital, from January 2016 to December 2016. Results: Twenty of 794 neonates admitted (2.5%) developed meningitis,with a male predominance (12 boys). The mean age of symptom presentation was 5 days. All patients were symptomatic. The most common clinical features were: fever, respiratory distress and seizure. Microbiological analysis of cerebrospinal fluid was positive in 14 cases and resulted in the isolation of several unusual species such as, Streptococcus pneumoniae (4 cases), Coagulase-negative Staphylococci (3 cases), Enterococci (2 cases), Acinetobacter baumannii (2 cases) and one case each of Escherichia coli , Neisseria meningitidis and Klebsiella pneumonia. Interestingly, the two A. baumannii cases were nosocomially-acquired, while the origins of the other infections were community-acquired. Gram-positive bacteria were more frequently responsible (9/14, 64%). All cases were treated with a combination of third-generation cephalosporins-aminoglycosides, 1 case as treated by by adding ciprofloxacin and 3 cases were treated by adding glycopeptide antibiotics to the clinical therapeutic regimes. We reported 3 cases complicated with hydrocephalus. The mortality rate was 25%. Conclusion: Bacterial meningitis is a medical emergency, and immediate diagnostic steps must be taken to establish the specific cause so that appropriate antimicrobial therapy can be initiated. Even with optimal therapy, morbidity and mortality may occur. Neurologic sequelae are common among survivors.

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Section: Discussionmentioning

confidence: 99%

Bacterial Meningitis Profile in Newborns: Is the Epidemiology Changing?

Bennaoui¹,

Slitine²,

Cissé³

et al. 2018

TOIDJ

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“…The MNCP constructed by the authors' group contains the 10 most common nosocomial species and 13 drug resistance genes; specifically, it includes the mecA, bla OXA , and bla KPC-2, as well as the bla CTX groups. It is reported that carbapenemase-and ESBLproducing K. pneumonia and A. baumannii, as well as methicillinresistant S. aureus (MRSA) and methicillin-resistant S. epidermidis (MRSE), play important roles in PNM (Almeida et al, 2014;Biswas et al, 2014;Krueger et al, 2004;Vallejo et al, 2017), which is a significant public health problem, because these pathogens are associated with an increase in the length of hospitalization and the cost of treatment, as well as high mortality and morbidity (Sansur et al, 2010;Walsh et al, 2017).…”

Section: Discussionmentioning

confidence: 99%

Evaluation of a micro/nanofluidic chip platform for the high-throughput detection of bacteria and their antibiotic resistance genes in post-neurosurgical meningitis

Zhang

Zheng

Zhang³

et al. 2018

International Journal of Infectious Diseases

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“…Staphylococcus aureus used to be the most common pathogenic bacteria of neonatal brain abscess, but in recent years, the number of neonatal brain abscess caused by anaerobic bacteria and Gram-negative bacteria has increased [12,13] . In most of the reports published, Citrobacter cruzi and Proteus are the most common microorganisms that cause brain abscess in neonates [14] . However, considering the cases in this study, Escherichia coli is the most common pathogenic bacteria.…”

Section: Etiology Of Brain Abscessmentioning

confidence: 99%

Neonatal Brain Abscess: Case Report of 12 Cases and Literature Review

Peng

Chen

2022

JCNR

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Objective: To investigate the etiological characteristics, clinical manifestations, and early identification methods of neonatal brain abscess. Methods: The baseline characteristics, clinical manifestations, and laboratory results of 12 neonatal brain abscess cases were retrospectively analyzed. Results: The clinical manifestations were fever, convulsion, and lethargy. A small number of them had respiratory and circulatory failure. The diagnosis made was based on imaging examination. All 12 cases were confirmed by cranial enhanced computed tomography (CT) or magnetic resonance imaging (MRI). Blood cultures of 9 cases were positive, with Escherichia coli in 6 cases, ?-hemolytic Streptococcus in 1 case, methicillin-resistant Staphylococcus aureus in 1 case, and Enterococcus faecium in 1 case. However, only 3 of them had positive cerebrospinal fluid (CSF) cultures. All the 12 neonates were treated with antibiotic therapy upon admission, with only 3 cases treated with surgery. Among them, 4 recovered and were discharged, while the remaining 8 discontinued their therapy. Conclusion: Escherichia coli is the most common pathogen of neonatal brain abscess in our study. The clinical manifestations of neonatal brain abscess are atypical, and the prognosis is poor. Respiratory and circulatory failure in children with intracranial infection may indicate the presence of brain abscess. For children with suspected brain abscess, cranial enhanced CT or MRI should be performed as soon as possible to make an early diagnosis. The prevention of brain abscess should be prioritized; neonates with sepsis or meningitis should receive prompt and strong antibiotic therapy in an effort to prevent the development of brain abscess.

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Neonatal Brain Abscess due to Extended-Spectrum Beta-Lactamase Producing Klebsiella pneumoniae

Cited by 5 publications

References 4 publications

Bacterial Meningitis Profile in Newborns: Is the Epidemiology Changing?

Bacterial Meningitis Profile in Newborns: Is the Epidemiology Changing?

Evaluation of a micro/nanofluidic chip platform for the high-throughput detection of bacteria and their antibiotic resistance genes in post-neurosurgical meningitis

Neonatal Brain Abscess: Case Report of 12 Cases and Literature Review

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