Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb

Rivera, Oscar E.; Varayoud, Jorgelina; Rodríguez, Horacio Adolfo; Muñoz-de-Toro, Mónica; Luque, Enrique H.

doi:10.1016/j.reprotox.2011.06.118

Cited by 93 publications

(83 citation statements)

References 56 publications

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“…We also found that exposure to BPA results in a lower weight of the lamb ovaries and a higher incidence of multiovular follicles (MOFs) on PND30 (Rivera et al 2011). These adverse effects may be mediated through abnormal early protein levels of ovarian estrogen receptors (ERs) and could alter ovarian function and female fertility (Rivera et al 2011). Nagel & Bromfield (2013) suggested that BPA can directly bind to both ERs and increase endogenous estrogen levels via upregulation of aromatase enzyme, increasing the overall estrogenic effects during development.…”

Section: Introductionmentioning

confidence: 89%

“…The lamb ovary is sensitive to disruption by EDC exposure during intrauterine life (Adams et al 1988, Adams 1995, Savabieasfahani et al 2006, Fowler et al 2008 or during early postnatal life (Rivera et al 2011). In sheep, a precocial species, we have previously demonstrated that low doses of s.c. BPA or DES injections from birth to postnatal day 14 (PND14) cause a decline in the stock of primordial follicles by stimulating follicular development and increasing follicular atresia (Rivera et al 2011).…”

Section: Introductionmentioning

confidence: 99%

“…In sheep, a precocial species, we have previously demonstrated that low doses of s.c. BPA or DES injections from birth to postnatal day 14 (PND14) cause a decline in the stock of primordial follicles by stimulating follicular development and increasing follicular atresia (Rivera et al 2011). We also found that exposure to BPA results in a lower weight of the lamb ovaries and a higher incidence of multiovular follicles (MOFs) on PND30 (Rivera et al 2011). These adverse effects may be mediated through abnormal early protein levels of ovarian estrogen receptors (ERs) and could alter ovarian function and female fertility (Rivera et al 2011).…”

Section: Introductionmentioning

confidence: 99%

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Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs

Rivera¹,

Varayoud²,

Rodríguez³

et al. 2015

Reproduction

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Bisphenol A (BPA) and diethylstilbestrol (DES) are xenoestrogens, which have been associated with altered effects on reproduction. We hypothesized that neonatal xenoestrogen exposure affects the ovarian functionality in lambs. Thus, we evaluated the ovarian response to exogenous ovine FSH (oFSH) administered from postnatal day 30 (PND30) to PND32 in female lambs previously exposed to low doses of DES or BPA (BPA50: 50 mg/kg per day, BPA0.5: 0.5 mg/kg per day) from PND1 to PND14. We determined: i) follicular growth, ii) circulating levels of 17b-estradiol (E 2 ), iii) steroid receptors (estrogen receptor alpha, estrogen receptor beta, and androgen receptor (AR)) and atresia, and iv) mRNA expression levels of the ovarian bone morphogenetic protein (BMPs) system (BMP6, BMP15, BMPR1B, and GDF9) and FSH receptor (FSHR). Lambs neonatally exposed to DES or BPA showed an impaired ovarian response to oFSH with a lower number of follicles R2 mm in diameter together with a lower number of atretic follicles and no increase in E 2 serum levels in response to oFSH treatment. In addition, AR induction by oFSH was disrupted in granulosa and theca cells of lambs exposed to DES or BPA. An increase in GDF9 mRNA expression levels was observed in oFSH-primed lambs previously treated with DES or BPA50. In contrast, a decrease in BMPR1B was observed in BPA0.5-postnatally exposed lambs. The modifications in AR, GDF9, and BMPR1B may be associated with the altered ovarian function due to neonatal xenoestrogen exposure in response to an exogenous gonadotropin stimulus. These alterations may be the pathophysiological basis of subfertility syndrome in adulthood.Reproduction (2015) 149 645-655

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Section: Introductionmentioning

confidence: 89%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs

Rivera¹,

Varayoud²,

Rodríguez³

et al. 2015

Reproduction

Self Cite

View full text Add to dashboard Cite

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“…Specifically, ovarian weight is lower in BPA-exposed animals and the number of primordial follicles is reduced as primordial follicle recruitment is accelerated. However, there is also an increase in the number of atretic antral follicles (Rivera et al 2011). Other physiological changes were also noted, including a reduced response of oestrogen to stimulation with FSH and changes in steroid receptors (Rivera et al 2015), which, in conjunction, may lead to future subfertility.…”

Section: Effects Of Edcs On Ovarian and Uterine Functionmentioning

confidence: 99%

Epigenetics and developmental programming of welfare and production traits in farm animals

Sinclair

Rutherford

Wallace

et al. 2016

Reprod. Fertil. Dev.

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Abstract. The concept that postnatal health and development can be influenced by events that occur in utero originated from epidemiological studies in humans supported by numerous mechanistic (including epigenetic) studies in a variety of model species. Referred to as the 'developmental origins of health and disease' or 'DOHaD' hypothesis, the primary focus of large-animal studies until quite recently had been biomedical. Attention has since turned towards traits of commercial importance in farm animals. Herein we review the evidence that prenatal risk factors, including suboptimal parental nutrition, gestational stress, exposure to environmental chemicals and advanced breeding technologies, can determine traits such as postnatal growth, feed efficiency, milk yield, carcass composition, animal welfare and reproductive potential. We consider the role of epigenetic and cytoplasmic mechanisms of inheritance, and discuss implications for livestock production and future research endeavours. We conclude that although the concept is proven for several traits, issues relating to effect size, and hence commercial importance, remain. Studies have also invariably been conducted under controlled experimental conditions, frequently assessing single risk factors, thereby limiting their translational value for livestock production. We propose concerted international research efforts that consider multiple, concurrent stressors to better represent effects of contemporary animal production systems.

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“…A number of recent studies have reported measurable biological effects in sheep exposed to BPA. These studies used exposure via daily sub-cutaneous injections over extended time periods during either the gestation (60 days 5000ug g -1 per day) or neonatal (14 days 50ng g -1 per day) period [Savabieasfahani et al, 2006;Rivera et al, 2011;Viega-Lopez et al, 2014]. In these latter studies, the exposure routes of BPA are not representative of those which will occur to grazing animals and do not take into account issues of the bioavailability of any BPA contained in the soil/herbage matrix.…”

Section: Introductionmentioning

confidence: 99%

A study on temporal trends and estimates of fate of Bisphenol A in agricultural soils after sewage sludge amendment

Zhang

Velly

Rhind

et al. 2015

Science of The Total Environment

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Neonatal exposure to bisphenol A or diethylstilbestrol alters the ovarian follicular dynamics in the lamb

Cited by 93 publications

References 56 publications

Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs

Neonatal exposure to xenoestrogens impairs the ovarian response to gonadotropin treatment in lambs

Epigenetics and developmental programming of welfare and production traits in farm animals

A study on temporal trends and estimates of fate of Bisphenol A in agricultural soils after sewage sludge amendment

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