Neonatal hemostasis and the use of thromboelastography/rotational thromboelastometry in the neonatal period

Katsaras, Georgios N; Gialamprinou, Dimitra; Kontovazainitis, Christos-Georgios; Psaroulaki, Evdokia; Mitsiakos, Georgıos

doi:10.23736/s2724-5276.23.07214-2

Cited by 1 publication

(1 citation statement)

References 90 publications

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“…Regarding neonates, viscoelastic tests are used in neonatal departments and have become part of the clinical routine [131]. However, no studies have assessed the hemostasis of newborns derived exclusively from pre-eclamptic mothers with TEG/ROTEM using neonatal (and not cordial) blood samples.…”

Section: Viscoelastic Tests May Be Helpful In Neonates Born To Pre-ec...mentioning

confidence: 99%

Hemostasis in Pre-Eclamptic Women and Their Offspring: Current Knowledge and Hemostasis Assessment with Viscoelastic Tests

Kontovazainitis,

Gialamprinou,

Theodoridis

et al. 2024

Diagnostics

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Pre-eclampsia (PE) is a placenta-mediated disease and remains a major cause of maternal and neonatal mortality and morbidity. As PE develops, normal pregnancy’s hypercoagulable balance is disrupted, leading to platelet hyperactivation, excessive pathological hypercoagulability, and perturbed fibrinolysis. This narrative review aims to summarize the current knowledge regarding hemostasis in PE compared with healthy gestation and the potential effects of maternal PE on neonatal hemostasis. Finally, it aims to discuss hemostasis assessments for normal pregnancies and PE, emphasizing the role of viscoelastic tests, namely, thromboelastography (TEG) and thromboelastometry (ROTEM), for monitoring PE-associated hemostatic alterations. The use of TEG/ROTEM for assessing the hemostatic profile of PE women has been little considered, even though conventional coagulation tests (CCTs) have not helped to monitor hemostasis in this population. Compared with normal pregnancy, TEG/ROTEM in PE reveals an excessive hypercoagulability analogous with the severity of the disease, characterized by higher-stability fibrin clots. The TEG/ROTEM parameters can reflect PE severity and may be used for monitoring and as predictive markers for the disease.

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Section: Viscoelastic Tests May Be Helpful In Neonates Born To Pre-ec...mentioning

confidence: 99%

Hemostasis in Pre-Eclamptic Women and Their Offspring: Current Knowledge and Hemostasis Assessment with Viscoelastic Tests

Kontovazainitis,

Gialamprinou,

Theodoridis

et al. 2024

Diagnostics

Self Cite

View full text Add to dashboard Cite

show abstract

Neonatal hemostasis and the use of thromboelastography/rotational thromboelastometry in the neonatal period

Cited by 1 publication

References 90 publications

Hemostasis in Pre-Eclamptic Women and Their Offspring: Current Knowledge and Hemostasis Assessment with Viscoelastic Tests

Hemostasis in Pre-Eclamptic Women and Their Offspring: Current Knowledge and Hemostasis Assessment with Viscoelastic Tests

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