Neonatal hypocalcemia and its relation to vitamin D and calcium supplementation

Elsary, Asmaa Younis; Elgameel, Alkassem A.; Mohammed, Wael; Zaki, Osman; Taha, Shaimaa A.

doi:10.15537/smj.2018.3.21679

Cited by 10 publications

(8 citation statements)

References 15 publications

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“…In a prior analysis, we also found that gestational age was not associated with neonatal vitD deficiency (data not shown). These findings are in keeping with previous studies, which have reported conflicting results regarding gestational age [18,27,28] and maternal education [11,14] as potential risk factors of neonatal vitD deficiency.…”

Section: Discussionsupporting

confidence: 92%

Maternal factors associated with neonatal vitamin D deficiency

Wang

Gao

Liu

et al. 2019

Journal of Pediatric Endocrinology and Metabolism

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Background An adequate maternal vitamin D (vitD) intake is rarely achieved in actual practice. The aim of this study was to assess maternal factors associated with neonatal vitD deficiency. Methods This is a single-institution prospective case-control study. Consecutive single-birth neonates admitted between September 2014 and February 2015 were prospectively enrolled. Serum 25-hydroxyvitamin D (25(OH)D) concentrations were measured by spectrometry. The associations between neonatal vitD deficiency (defined as 25(OH)D <15 ng/mL) and several maternal characteristics, including body mass index (BMI) at delivery, education, health insurance status, birth season, sun exposure time, egg consumption, and vitD supplementation during pregnancy, were examined using multivariable logistic regression and their respective odds ratios (ORs) reported. Results A total of 125 mother-infant dyads were enrolled, with a gestational age of 36.8±2.7 weeks. Fifty-six percent (70/125) of the neonates had vitD deficiency. Maternal factors that were significantly associated with vitD deficiency included winter birth, insufficient sun exposure time, high maternal BMI at delivery, insufficient egg consumption, insufficient vitD supplementation during pregnancy, and disadvantaged health insurance. Disadvantaged insurance status and insufficient vitD supplementation during pregnancy were the two most influential factors of neonatal vitD deficiency, with an OR of 7.5 (95% confidence interval [CI], 2.0–37.6) and 7.0 (95% CI, 2.7–20.7), respectively. Conclusions Neonatal vitD deficiency is very rampant. An individualized vitD supplementation strategy may be developed by taking into consideration pregnant women’s socioeconomic status and lifestyles.

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Section: Discussionsupporting

confidence: 92%

Maternal factors associated with neonatal vitamin D deficiency

Wang

Gao

Liu

et al. 2019

Journal of Pediatric Endocrinology and Metabolism

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“…A recent study 19 reported high incidence of hypocalcemia in neonatal seizures admitted in level III neonatal intensive care units. Recent studies by Elsary et al 20 and Do HJ et al 21 have reported neonatal hypocalcemia and neonatal seizures and support the findings of present study. The limitations of present study include; first-small sample size, second-poor ethnical group of sample population was selected, third-other variables were not measured due to financial issues.…”

Section: Discussionsupporting

confidence: 92%

Serum calcium level in neonatal seizures presenting at a Tertiary Care Hospital.

Maheshwari¹,

Noor²,

Bashir³

et al. 2021

TPMJ

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Objectives: The present study was conducted to detect serum calcium level in neonatal seizures presenting at a Tertiary Care Hospital. Study Design: Case control study. Setting: Department of Paediatrics, Shaheed Muhtrama Benazir Bhutto Medical. College Layari General Hospital, Karachi, Sindh. Period: June 2017 to January 2018. Material & Methods: The sample comprised of 100 cases and 100 controls that were selected through non- probability purposive sampling through inclusion and exclusion criteria. Sera were separated through centrifugation of blood for measuring the serum calcium levels. Data was analyzed on SPSS software (SPSS ver 22.0, IBM, Incorporation, USA) at 95% confidence interval (P≤0.05). Results: Of 100 cases and 100 controls, the male and female were noted as 61 vs. 57 and 39 vs. 43 respectively (P > 0.05). In cases, the mean± SD Ca++ was noted as 4.17±1.58 mg/dl while in control it was noted as 8.15± 1.05 mg/dl. Ca++ levels as low as 3.07 mg/dl were noted in the neonatal seizure cases. Normocalcaemia was noted in 81 controls vs. 11 cases and hypocalcaemia in 18 controls vs. 89 cases. Conclusion: The present study reports hypocalcemia is common in neonatal seizures. Pediatricians must evaluate for timely correction of serum calcium to prevent long term neurological sequelies.

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“…This finding of ours is in contradictition to general findings in other studies done in the past. [3][4][5] However, study done by Elsary AY et al 11 also had larger proportion of term babies in comparison to preterm babies like ours. Since our hospital is a referral hospital, substantial number of babies with perinatal asphyxia and preterm babies who presented to our set up had already received prophylactic IV calcium.…”

Section: Discussionmentioning

confidence: 71%

“…This fact has been demonstrated in other studies too. 11,12 We had found mean serum calcium level of 8.6 mg/ dl for term babies and 8.1 mg/dl for preterm babies.…”

Section: Discussionmentioning

confidence: 93%

“…However, some studies have shown more frequent late onset hypocalcemia than early onset. 11,12 This may be explained by the fact that these studies were from middle east countries where clothing culture is different leading to large incidence of vitamin D deficiency in mothers resulting in increase in late onset hypocalcaemia in newborns. In contrary, we have higher incidence of perinatal asphyxia and preterm deliveries and thus, there is higher possibility of early onset hypocalcaemia in our set up.…”

Section: Discussionmentioning

confidence: 99%

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Occurrence of Hypocalcaemia in Admitted Neonates in NICU

Shrestha

Thapa

Subedi

et al. 2021

Med. J. Shree Birendra Hosp.

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Introduction: Hypocalcaemia is common metabolic manifestation in neonates and associated with both maternal and foetal conditions. Hypocalcaemia is labeled if term neonate’s total serum calcium is < 8 mg/dl and preterm has < 7 mg/dl. Association of neonatal and maternal hypovitaminosis D is very common. . Methods: One year retrospective study was conducted in a tertiary level private children hospital of Kathmandu, Nepal from 2018 June to 2019 July. Total 299 cases were selected and serum calcium were sent and analysed for its association with illness, associated maternal hypovitaminosis D and other relevant maternal tests. Result: Among 686 NICU cases, calcium level was sent for 299 cases. Among these, 254 were term and 45 were preterm babies and male to female ratio was 4:1. Mean calcium in term babies were 8.6 mg/dl and in preterm it was 8.1 mg/dl. Hypocalcaemia was found in 19% of cases with mean calcium level was 7.1 ± 0.84 mg/dl and severe hypocalcaemia accounted for 12%. There was no significant presence of hypocalcaemia in relation to gestation of newborn (p value 0.798). We found higher incidence of late onset hypocalcemia than early onset hypocalcemia but was not of statistical significance (p value 0.771). Associated disease were perinatal asphyxia, congenital heart diseases and prematurity. Among 27 late onset hypocalcaemia, 22% had hypovitaminosis D both in neonates and mother. Conclusions: Neonatal hypocalcaemia is a common condition associated with sick newborns. In late hypocalcaemia both newborn and mother should be screened for associated lab tests like vitamin D, magnesium, PTH as there may be association between the two.

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Neonatal hypocalcemia and its relation to vitamin D and calcium supplementation

Cited by 10 publications

References 15 publications

Maternal factors associated with neonatal vitamin D deficiency

Maternal factors associated with neonatal vitamin D deficiency

Serum calcium level in neonatal seizures presenting at a Tertiary Care Hospital.

Occurrence of Hypocalcaemia in Admitted Neonates in NICU

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