Neonatal intestinal obstruction due to absence of intestinal musculature: A new entity

Emanuel, Benjamin; Gault, J. E.; Sanson, J

doi:10.1016/s0022-3468(67)80213-6

Cited by 39 publications

(20 citation statements)

References 6 publications

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“…In the literature, the pathogenesis of the muscular defect is divided into two types, congenital and acquired [3]. In the congenital type [2,4], the intact mucosa with long villi, good epithelialization, and the edematous, congested submucosal layer make it appear unlikely that the cause of the muscle defect is transmural ischemia, suggesting that the defect may be congenital. Although there were short mucosal villi and dilated vessels in our cases, short villi can regenerate after ischemic damage.…”

Section: Discussionmentioning

confidence: 99%

The mechanism of focal intestinal perforations in neonates with low birth weight

Tatekawa

Muraji

Imai

et al. 1999

Pediatric Surgery International

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Among 36 neonates with intestinal perforations (IP) between 1975 and 1996, 5 had necrotizing enterocolitis (NEC IP) and 10 had focal IPs (FIP). A histologic review of the bowel near the perforations was made to see if there was any difference between cases of NEC IP and FIP. In 1 case of NEC IP, a defect in the musculature was found in addition to disappearance of the mucosal villi and dilated vessels or hemorrhage in the submucosa. Thinning or absence of the intestinal musculature and short villi in the mucosa was observed in 3 cases of FIP, but the acute ischemic changes in FIP were much less than in NEC IP. Hypothesizing that the defective musculature in FIP may be acquired by a vascular accident either before or after birth, we examined the histology of the latest consecutive infants diagnosed as having meconium peritonitis (MP) due to in-utero volvulus and perforation. In the tissue near the perforation, there was an identical focus of thinning and interruption of the musculature while the acute ischemic changes were minimal. We speculate that thinning or absence of the intestinal musculature in FIP may be a result of a transient ischemic event occurring in-utero and that FIP may develop in the damaged intestine after birth when it is fully dilated.

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Section: Discussionmentioning

confidence: 99%

The mechanism of focal intestinal perforations in neonates with low birth weight

Tatekawa

Muraji

Imai

et al. 1999

Pediatric Surgery International

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“…In children these disorders most commonly are congenital, but can also be acquired. Some defects appear to be primarily of morphogenesis with an absence of one of the intestinal muscle coats 3 , absence of all intestinal muscle layers 4,5 , or the presence of an additional oblique muscle coat 6 being described. In others the abnormality is at the cellular level consisting of fibrosis and myocyte vacuolation detected by light microscopy on conventionally stained histological sections [7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25] .…”

Section: Introductionmentioning

confidence: 99%

Histological phenotypes of enteric smooth muscle disease causing functional intestinal obstruction in childhood

Smith

Milla

1997

Histopathology

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“…Ischaemia is considered a pathogenic factor in both NEC and IP, but it has not been identified as the main cause or trigger, so the mechanism is still considered to be multifactorial. Defects of the intestinal muscular layer support the ischaemic hypothesis, either congenital [9] or acquired [12].…”

Section: Introductionmentioning

confidence: 70%

Comparative Study between Isolated Intestinal Perforation and Necrotizing Enterocolitis

Tarrado

Castañón²,

Thió³

et al. 2005

Eur J Pediatr Surg

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Comparing the groups, we found statistical significant differences in isolated perforation cases with these risk factors: extreme prematurity, very low birth weight, abruptio placenta, intubation and neonatal mechanical ventilation, umbilical catheterization, precocious sepsis, and indomethacin therapy. A more precocious operation and a good prognosis also reached statistical significance. In the other hand, we found statistically significant differences in NEC with congenital cardiopathy (excluding isolated patent ductus arteriosus), with intestinal pneumatosis, with diffuse bowel involvement and a worse prognosis. Risk factors and pathologic findings seem to support an ischaemic pathogenesis in both diseases.

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Neonatal intestinal obstruction due to absence of intestinal musculature: A new entity

Cited by 39 publications

References 6 publications

The mechanism of focal intestinal perforations in neonates with low birth weight

The mechanism of focal intestinal perforations in neonates with low birth weight

Histological phenotypes of enteric smooth muscle disease causing functional intestinal obstruction in childhood

Comparative Study between Isolated Intestinal Perforation and Necrotizing Enterocolitis

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