Neonatal Jaundice: The Other Side of the Coin in the Development of Allergy

Abstract

Objective The current study aims to assess the association between different characteristics of neonatal jaundice and common types of allergic diseases in childhood (as bronchial asthma, acute urticaria, and allergic rhinitis). Study Design A case-control study is conducted on 300 allergic children and 300 healthy children as a control group at Fayoum University Hospital. The study was conducted over a span of 2 years, from May 2016 to May 2018. Bronchial asthma, allergic rhinitis, and acute urticaria diagnoses were based on physician clinical examination using specific guidelines for each. For the data regarding children's demographic and maternal characteristics, a structured questionnaire was used. Regarding neonatal jaundice, data were collected from the patients' hospital records. Results Children with neonatal jaundice are more likely to develop allergy with 57% higher than neonates without jaundice. Early onset jaundice and treatment by phototherapy have statistically significant association with the development of allergic diseases. Conclusion Different aspects of neonatal jaundice are associated with the development of common allergic diseases in children.

Neonatal jaundice, phototherapy and childhood allergic diseases: An updated systematic review and meta‐analysis

“…Nineteen studies were in the qualitative synthesis. [10][11][12][13][14][15][25][26][27][28][29][30][31][32][33][34][35][36][37] In the end, fourteen studies reporting the effect estimate were synthesized in the meta-analysis. Our search did not reveal any ongoing and unpublished studies.…”

“…Table 1 shows the characteristics of the 19 included studies, [10][11][12][13][14][15][25][26][27][28][29][30][31][32][33][34][35][36][37] which included three case-control studies, 26,27,32 two cross-sectional studies, 25,33 and 14 longitudinal cohort studies. [10][11][12][13][14][28][29][30][31][34][35][36][37] There were 14 articles related to jaundice [12][13][14][15][25][26][27][29][30][31]33,34,36,…”

The Effects of Bilirubin and Lumirubin on Metabolic and Oxidative Stress Markers

“…*, p < 0.05; #, p < 0.001, compared to control; N 3. Auger et al, 2019;Safar and Elsary, 2020). In addition, practically no mechanistic studies have been performed to address these issues.…”

“…Nevertheless, the metabolism of BR photoisomers seems to have clinical importance. Although PT is an effective, noninvasive, and relatively safe therapeutic method, accompanying potential side effects of the treatment are known in clinical practice, including: hypocalcemia (Khan et al, 2016), dehydration (Xiong et al, 2011), ileus (Raghavan et al, 2005), type 1 diabetes (Mcnamee et al, 2012), allergies (Safar and Elsary, 2020), increased incidence of cancer at advanced age (Auger et al, 2019), and even increased mortality of extremely low birthweight infants (Arnold et al, 2014).…”

Yenidoğan Sarılık Ölçüm Yöntemleri ile Felix von Luschan Deri Rengi Skalasının Karşılaştırılması

“…If untreated, it can develop into allergies or other diseases that can prove fatal (20). Early diagnosis and treatment with phototherapy can prevent the development of other diseases (21). There exist various methods for the diagnosis of neonatal jaundice, but these methods are invasive and time-consuming.…”