Neonatal lesion of forebrain cholinergic neurons: Further characterization of behavioral effects and permanency

Pappas, Bruce A.; Payne, K.B.; Fortin, T.; Sherren, Nicole

doi:10.1016/j.neuroscience.2005.02.040

Cited by 22 publications

(20 citation statements)

References 28 publications

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“…injections of 192 IgG-saporin. Although the lesions were submaximal in both the septal region and the NBM (as was also the case in the present study), they impaired acquisition of a water-maze task, but had no effect in a five choice serial reaction time task taxing visual attention (Pappas et al, 2005). In another study, it was shown that after close to complete immunotoxic lesions of NBM cholinergic neurons, however, rats exhibited dramatic impairments in the latter task (Lehmann et al, 2003).…”

Section: Igg-saporin Lesions: Memory Vs Attentionsupporting

confidence: 77%

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Combined Damage to Entorhinal Cortex and Cholinergic Basal Forebrain Neurons, Two Early Neurodegenerative Features Accompanying Alzheimer's Disease: Effects on Locomotor Activity and Memory Functions in Rats

Traissard

Herbeaux

Cosquer

et al. 2006

Neuropsychopharmacol

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In Alzheimer's disease (AD), cognitive decline is linked to cholinergic dysfunctions in the basal forebrain (BF), although the earliest neuronal damage is described in the entorhinal cortex (EC). In rats, selective cholinergic BF lesions or fiber-sparing EC lesions may induce memory deficits, but most often of weak magnitude. This study investigated, in adult rats, the effects on activity and memory of both lesions, alone or in combination, using 192 IgG-saporin (OX7-saporin as a control) and L-N-methyl-D-aspartate to destroy BF and EC neurons, respectively. Rats were tested for locomotor activity in their home cage and for working-and/or reference-memory in various tasks (water maze, Hebb-Williams maze, radial maze). Only rats with combined lesions showed diurnal and nocturnal hyperactivity. EC lesions impaired working memory and induced anterograde memory deficits in almost all tasks. Lesions of BF cholinergic neurons induced more limited deficits: reference memory was impaired in the probe trial of the water-maze task and in the radial maze. When both lesions were combined, performance never improved in the water maze and the number of errors in the Hebb-Williams and the radial mazes was always larger than in any other group. These results (i) indicate synergistic implications of BF and EC in memory function, (ii) suggest that combined BF cholinergic and fiber-sparing EC lesions may model aspects of anterograde memory deficits and restlessness as seen in AD, (iii) challenge the cholinergic hypothesis of cognitive dysfunctions in AD, and (iv) contribute to open theoretical views on AD-related memory dysfunctions going beyond the latter hypothesis.

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Section: Igg-saporin Lesions: Memory Vs Attentionsupporting

confidence: 77%

“…Although the issue of an attentional bias cannot be rebutted, it may be qualified on the basis of a few previous findings. First, Pappas et al (2005) performed neonatal lesions of the BF cholinergic system by i.c.v. injections of 192 IgG-saporin.…”

Section: Igg-saporin Lesions: Memory Vs Attentionmentioning

confidence: 99%

Combined Damage to Entorhinal Cortex and Cholinergic Basal Forebrain Neurons, Two Early Neurodegenerative Features Accompanying Alzheimer's Disease: Effects on Locomotor Activity and Memory Functions in Rats

Traissard

Herbeaux

Cosquer

et al. 2006

Neuropsychopharmacol

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“…Persistent reductions in cBF volume in VP/VLBW adults are consistent with experimental research in animal models demonstrating a weak potential of the cholinergic forebrain to recover from neonatal lesions (41). While our analyses demonstrate a relatively specific role of the cBF in premature birth-associated cognitive deficits that last into adulthood, one would not expect cBF volume to be the only factor related to variance in intellectual abilities among VP/VLBW adults.…”

Section: Resultssupporting

confidence: 84%

Reduced Cholinergic Basal Forebrain Integrity Links Neonatal Complications and Adult Cognitive Deficits After Premature Birth

Grothe¹,

Scheef

Bäuml

et al. 2017

Biological Psychiatry

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“…The SAP-induced reduction of cortical thickness, dendritic branching, and connectivity (Höhmann et al, 1988;Robertson et al, 1998) may destabilize the cortical networks in their ability to sustain oscillatory coupling. In turn, the less frequent and shorter oscillations timing the neurons within local prelimbic networks may worsen the Hebb-like refinement of these networks over the early developmental phase and may contribute to miswiring relevant for mnemonic and executive deficits (Pappas et al, 2005). The third piece of evidence for the cholinergic control of prelimbic gamma episodes is the result of local pharmacological manipulation of mAChRs and nAChRs in the Cg and PL.…”

Section: Continuous Activity (P14 -P15)mentioning

confidence: 99%

Cholinergic Control in Developing Prefrontal–Hippocampal Networks

Janiesch¹,

Krüger²,

Poschel³

et al. 2011

J. Neurosci.

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The cholinergic drive enhances input processing in attentional and mnemonic context by interacting with the activity of prefrontalhippocampal networks. During development, acetylcholine modulates neuronal proliferation, differentiation, and synaptic plasticity, yet its contribution to the maturation of cognitive processing resulting from early entrainment of neuronal networks in oscillatory rhythms remains widely unknown. Here we show that cholinergic projections growing into the rat prefrontal cortex (PFC) toward the end of the first postnatal week boost the generation of nested gamma oscillations superimposed on discontinuous spindle bursts by acting on functional muscarinic but not nicotinic receptors. Although electrical stimulation of cholinergic nuclei increased the occurrence of nested gamma spindle bursts by 41%, diminishment of the cholinergic input by either blockade of the receptors or chronic immunotoxic lesion had the opposite effect. This activation of locally generated gamma episodes by direct cholinergic projections to the PFC was accompanied by indirect modulation of underlying spindle bursts via cholinergic control of hippocampal theta activity. With ongoing maturation and switch of network activity from discontinuous bursts to continuous theta-gamma rhythms, accumulating cholinergic projections acting on both muscarinic and nicotinic receptors mediated the transition from high-amplitude slow to low-amplitude fast rhythms in the PFC. By exerting multiple actions on the oscillatory entrainment of developing prefrontal-hippocampal networks, the cholinergic input may refine them for later gating processing in executive and mnemonic tasks.

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Neonatal lesion of forebrain cholinergic neurons: Further characterization of behavioral effects and permanency

Cited by 22 publications

References 28 publications

Combined Damage to Entorhinal Cortex and Cholinergic Basal Forebrain Neurons, Two Early Neurodegenerative Features Accompanying Alzheimer's Disease: Effects on Locomotor Activity and Memory Functions in Rats

Combined Damage to Entorhinal Cortex and Cholinergic Basal Forebrain Neurons, Two Early Neurodegenerative Features Accompanying Alzheimer's Disease: Effects on Locomotor Activity and Memory Functions in Rats

Reduced Cholinergic Basal Forebrain Integrity Links Neonatal Complications and Adult Cognitive Deficits After Premature Birth

Cholinergic Control in Developing Prefrontal–Hippocampal Networks

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