Neonatal Lupus Erythematosus

Histopathologic characteristics of neonatal cutaneous lupus erythematosus: description of five cases and literature review

“…The aim of this paper was to review five new cases comparing our data with those appeared in the literature (Table 1). 1,7–49 …”

Neonatal Lupus Erythematosus: A Review

“…One-third of mothers wfio give birth to infants with NLE have SLE. (1,2,8,(32)(33)(34)(35)(36)(37)(38) Another third develop manifestations of other CTD. The remaining third will remain disease free despite the presence of serologic abnormalities in 75% of them.…”

“…(1,20,(23)(24)(25)28) Of those who develop SLE, 75% will do so before pregnancy, and the other 25% during or after gestation. Other maternal CTD reported in association with NLE include nonspecific arthritis, (1,13,23) Raynaud's phenomenon, (13,30) rheumatoid arthritis, (14) discoid LE, (22) mixed CTD, (30) and undifferentiated CTD. (16) Of the women with SLE who give birth to babies with NLE, 40% show evidence of renal involvement during pregnancy.…”

“…(23) Direct immunofiuorescence studies of skin biopsies are positive in 55% of these women. (1,13,20,(22)(23)(24)(25)27) A lupus band and perivascular immune deposits are the common findings, although some women may show epidermal nuclear fluorescence. (23)…”

“…The skiti is a major target organ iti many vasculitis sytidromes, and the halltnark of HSP is palpable cutaneous purpura. Other dominant features include arthralgia, nephritis, abdominal pain, and gas-trointestinal bleeding (1,2). Although HSP has been recognized as a distinct clinical entity for over 100 years, it remains poorly understood.…”