Neonatal malnutrition programs the oxidant function of macrophages in response to Candida albicans

Costa, Thacianna Barreto da; Morais, Natália Gomes de; Pedrosa, Amanda Lúcia Farias; Albuquerque, Suênia da Cunha Gonçalves de; Castro, Maria Carolina Accioly Brelaz de; Pereira, Valéria Rêgo Alves; Paiva-Cavalcanti, Milena de; Castro, Célia Maria Machado Barbosa de

doi:10.1016/j.micpath.2016.02.012

Cited by 8 publications

(3 citation statements)

References 43 publications

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“…Studies in rats with severe malnutrition suggested that the increase in the susceptibility of infection is largely attributable to the functional defects of mononuclear and polymorphonuclear cells, whereby, in hosts, immunocompetence conditions develop an important function of the activation of the early immune response and the connection of the adaptive immune response in its function as an antigen-presenting cell (such as om the case of MDMs) [ 19 , 46 ]. However, very few studies have supported the role and deregulation of these cells in children with malnutrition.…”

Section: Discussionmentioning

confidence: 99%

Impact of Heat-Killed Lactobacillus casei Strain IMAU60214 on the Immune Function of Macrophages in Malnourished Children

et al. 2020

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Malnutrition is commonly associated with immunological deregulation, increasing the risk of infectious illness and death. The objective of this work was to determine the in vitro effects of heat-killed Lactobacillus casei IMAU60214 on monocyte-derived macrophages (MDMs) from well-nourished healthy children, well-nourished infected children and malnourished infected children, which was evaluated by an oxygen-dependent microbicidal mechanism assay of luminol-increase chemiluminescence and the secretion of tumor necrosis factor (TNF-α), interleukin (IL-1β), IL-6 and IL-10, as well as phagocytosis using zymosan and as its antibacterial activity against Salmonella typhimurium, Escherichia coli and Staphylococcus aureus. We found that reactive oxygen species (ROS), secretion cytokines (TNFα, IL-1β, IL-6 and IL-10 levels), phagocytosis and bactericidal capacity increased in all groups after pre-treatment with heat-killed L. casei IMAU60214 at a ratio of 500:1 (bacteria:MDM) over 24 h compared with MDM cells without pre-treatment. The results could indicate that heat-killed L. casei IMAU60214 is a potential candidate for regulating the immune function of macrophages.

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Section: Discussionmentioning

confidence: 99%

Impact of Heat-Killed Lactobacillus casei Strain IMAU60214 on the Immune Function of Macrophages in Malnourished Children

et al. 2020

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“…Likewise, Mφ from mice fed a low protein diet demonstrated increased Leishmania infantum parasite burden compared to those isolated from nourished mice [110]. Suppressed NFκB activity [111] and reduction in the production of GM-CSF growth factor [112] and ROS and NO [113] were also observed in peritoneal and alveolar Mφ isolated from malnourished (vs. nourished) animals, suggesting poor Mφ inflammatory function in nutrition-deficient states. These studies point to the importance of nutritional availability for Mφ to prompt a proinflammatory response, and delineating the mechanism of how metabolic deficiency links to function of Mφ in malnourished states will be useful to define novel methods for improving infection outcomes.…”

Section: Relevance Of Mφ Function In Metabolic Disordersmentioning

confidence: 99%

Metabolic programming of macrophage functions and pathogens control

Koo

Garg

2019

Redox Biology

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Macrophages (Mφ) are central players in mediating proinflammatory and immunomodulatory functions. Unchecked Mφ activities contribute to pathology across many diseases, including those caused by infectious pathogens and metabolic disorders. A fine balance of Mφ responses is crucial, which may be achieved by enforcing appropriate bioenergetics pathways. Metabolism serves as the provider of energy, substrates, and byproducts that support differential Mφ characteristics. The metabolic properties that control the polarization and response of Mφ remain to be fully uncovered for use in managing infectious diseases. Here, we review the various metabolic states in Mφ and how they influence the cell function.

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“…Son escasos los reportes de valores hematológicos de cachorros de 30 días (4 semanas) por lo que la presente investigación constituye un aporte significativo para los médicos veterinarios dedicados a este campo, así quienes deben atender a pacientes de esta edad no tendrán que interpretar los resultados del hemograma con valores hematológicos de animales adultos 2,6 .…”

Section: Discussionunclassified

Efecto de la glutamina y aminoácidos de cadena ramificada en los parámetros hematológicos y bioquímicos de cachorros caninos

et al. 2022

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El objetivo del estudio fue determinar la influencia de glutamina (GLN) y BCAAs (leucina, isoleucina y valina) sobre los parámetros hematológicos y bioquímicos de los cachorros. Se reclutaron 31 cachorros mestizos de 30 días, provenientes de cuatro camadas. Aleatoriamente en cada camada se estableció un grupo control (sin suplemento) y 3 tratamientos: T1 (GLN 0,5 g/kg/día/PO), T2 (BCAAs, 0.25 g/kg/día/PO) y T3 (GLN 0,5 g/kg+BCAAs 0,25 g/kg/día/PO), que se mantuvieron 90 días en ambiente controlado en igualdad de condiciones, alimentados dos veces al día individualmente, las muestras se tomaron a los 30 y 120 días de edad. Se aplicó un diseño en bloques al azar empleando a la camada como factor de bloque, se realizaron estadísticas descriptivas y pruebas de normalidad, además ANOVA para verificar variaciones entre tratamientos y Tukey para posicionar los tratamientos. A los 30 días las medias y rangos de los parámetros hematológicos y bioquímicos fueron similares. A los 120 días en los parámetros hematológicos se determinaron diferencias (p<0.05) en función del bloque, no así del tratamiento (p>0.05), sin embargo, el promedio de leucocitos (10.33 10*9/L) y el promedio de neutrófilos (7.17 10*9/L) del T2 fueron superiores al promedio del grupo control y de los otros tratamientos mostrando diferencia significativa (p<0.05) solo a un IC del 90%. Los parámetros de la bioquímica sanguínea no mostraron diferencias (p>0.05). En conclusión, se evidenció un efecto positivo en la inmunidad innata, resultando favorable la suplementación con BCAAs, sin evidencia de toxicidad.

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Neonatal malnutrition programs the oxidant function of macrophages in response to Candida albicans

Cited by 8 publications

References 43 publications

Impact of Heat-Killed Lactobacillus casei Strain IMAU60214 on the Immune Function of Macrophages in Malnourished Children

Impact of Heat-Killed Lactobacillus casei Strain IMAU60214 on the Immune Function of Macrophages in Malnourished Children

Metabolic programming of macrophage functions and pathogens control

Efecto de la glutamina y aminoácidos de cadena ramificada en los parámetros hematológicos y bioquímicos de cachorros caninos

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