Neonatal Mortality Risk in Relation to Gestational Age and Birthweight

Verloove-Vanhorick, S.P.; Verwey, R.A.; Brand, Ronald; Gravenhorst, J. Bennebroek; Keirse, Marc J. N. C.; Ruys, J.H.

doi:10.1016/s0140-6736(86)90713-0

Cited by 170 publications

(39 citation statements)

References 21 publications

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“…The concentration of lamellar bodies contained in samples of amniotic fl uid is one method commonly used to assess fetal lung maturity. Lamellar bodies can be counted in the platelet channel of most electronic cell counters [1] . Results are calculated in units of particle density per microliter of amniotic fl uid.…”

Section: Introductionmentioning

confidence: 99%

Comparison of Lamellar Body Counts Using Light Microscopy with Standard Coulter Counter Techniques to Assess Fetal Lung Maturity

Hunter

McKenna²,

Baptista³

2006

Gynecol Obstet Invest

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Objective: To determine if lamellar body counts determined using light microscopy and a manual hemochromocytometer correlate with counts made on standard electronic cell counters. Methods: Aliquots of amniotic fluid samples obtained by amniocentesis to assess fetal lung maturity were divided into two sterile tubes. One tube was sent immediately to be counted in a cell counter by standard technique and the other tube was stored at –70°C until manual counting could be performed. Manual counts on the same samples were made on two different occasions. Intra-observer variability and correlation with the standard technique was determined. Pearson coefficient was calculated. Results: There were 11 specimen pairs. The intra-observer correlation was significant: intraclass correlation coefficient 0.95 (CI 0.84–0.99). There was significant correlation between the Coulter counter lamellar body counts and manual counts: intraclass correlation coefficients 0.88 (CI 0.62–0.97) and 0.92 (CI 0.73–0.98), respectively. Conclusion: Lamellar body counts determined by light microscopy correlate well with results obtained for lamellar body counts using standard Coulter counter techniques. Results of this pilot study show that this experimental method of evaluating fetal lung maturity deserves further evaluation.

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Section: Introductionmentioning

confidence: 99%

Comparison of Lamellar Body Counts Using Light Microscopy with Standard Coulter Counter Techniques to Assess Fetal Lung Maturity

Hunter

McKenna²,

Baptista³

2006

Gynecol Obstet Invest

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“…The POPS cohort comprised 94% (n = 1,338) of all newborn infants born alive in the Netherlands in 1983 with a gestational age (GA) <32 weeks and/or a birth weight <1,500 g [11]; 959 infants survived until the age of 19, and 312 died in the neonatal period (by definition during the first 28 days of life), 51 in the 1st year of life and 16 after the 1st year of life. For this study, we selected the individuals born SGA or with a low HC or low weight adjusted for length.…”

Section: Methodsmentioning

confidence: 99%

“…In 1983, the Collaborative Project on Preterm and SGA infants in The Netherlands (POPS) started an ongoing nationwide follow-up study on the effects of prematurity and SGA on later outcome [11]. The aim of our study is to investigate the effect of catch-up growth in weight, length, HC and weight adjusted for length in the 1st year on cognition, health-related quality of life (HRQoL), problem behavior, height and weight status in young adults in the POPS study.…”

Section: Introductionmentioning

confidence: 99%

The Effect of Early Catch-Up Growth on Health and Well-Being in Young Adults

Dommelen¹,

Pal²,

Gravenhorst³

et al. 2014

Ann Nutr Metab

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Aim: To study the effect of catch-up growth in the 1st year on cognition, health-related quality of life (HRQoL), problem behavior and growth in young adults. Methods: We included individuals without severe complications and born small for gestational age (SGA; n = 228 for weight, n = 203 for length) or with a low head circumference (HC, n = 178) or a low weight adjusted for length (n = 64) in the Collaborative Project on Preterm and SGA Infants. Neonatal growth was standardized (standard deviation scores for gestational age, SDS_GA) according to GA-specific reference charts. Catch-up growth was defined as SDS_GA at 1 year of age adjusted for SDS_GA at birth. Cognition was defined by the Multicultural Capacity Test-Intermediate Level, HRQoL by the London Handicap Scale (LHS) and the Health Utility Index Mark 3 categorized into 4 levels (Multi-Attribute Utility, MAU), and problem behavior by the Young Adult Self-Report. We adjusted for potential confounders. Results: Most adults were born preterm (93.7%). A higher catch-up growth in the 1st year was associated with better cognition (B = 2.57, 95% CI 0.08-5.05 for weight), less disabilities according to the LHS (B = 2.06, 95% CI 0.35-3.78 for HC) and the MAU (OR = 0.67, 95% CI 0.48-0.95 for HC) and higher final height (B = 0.33, 95% CI 0.18-0.47 for weight; B = 0.41, 95% 0.28-0.55 for length, and B = 0.18, 95% CI 0.04-0.33 for HC) in young adulthood. Conclusion: There are long-term benefits of catch-up growth.

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“…Al though morbidity and mortality relate better to gestational age than to birthweight [1][2][3][4][5][6], most articles report survival and outcome by birthweight as weight is easily and objectively measured [7][8][9], In many instances, obstetric dates are imprecise, and gestational age is esti mated by evaluating physical and neurologi cal properties [10][11][12][13], The tendency to over estimate gestational age of VLBW infants re sults from standardization of these methods with more mature neonatal populations [14][15][16][17], Chronic stress, maternal hypertension, and other adverse intrauterine conditions may accelerate neurological maturation [18,19]. A rapid, accurate, and reproducible method of clinically assessing gestational mat uration is needed.…”

Section: Introductionmentioning

confidence: 99%

Gestational Age Correlates with Skin Reflectance in Newborn Infants of 24–42 Weeks Gestation

et al. 1993

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Accurate gestational age determination is limited in very low birthweight infants using neurological and physical assessments. As one of the markers of intrauterine development, skin maturation is assessed qualitatively by pediatricians. Based on this observation, we hypothesize that skin reflectance relates directly to gestational age. Light was delivered and collected from the skin through a topically placed optical patch. Reflected light was detected by the spectrophotometer and corrected by an adjacent laptop computer to yield the true total diffuse reflectance as a function of wavelength between 380-820 nm. The calculated reflectance at 837 nm (R₈₃₇) where it is independent of melanin, was determined by extrapolation from the reflectance at 650 and 750 nm. Sixty-four neonates of different races with gestational ages of 24-42 weeks were studied at 2-151 h of age. R₈₃₇ was related exponentially to gestational age (GA) by the equation R₈₃₇ = R_max{1 –– exp[––(GA –– G₀)/Τ]}, where R_max is the maximal value of R₈₃₇, G₀ is an apparent delay time before dermal scattering increases rapidly, and Τ is a time constant, r = 0.88, p < 0.001. In summary, the extrapolated skin reflectance offers a quantitative and objective assessment of gestational age which is independent of melanin and sex.

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Neonatal Mortality Risk in Relation to Gestational Age and Birthweight

Cited by 170 publications

References 21 publications

Comparison of Lamellar Body Counts Using Light Microscopy with Standard Coulter Counter Techniques to Assess Fetal Lung Maturity

Comparison of Lamellar Body Counts Using Light Microscopy with Standard Coulter Counter Techniques to Assess Fetal Lung Maturity

The Effect of Early Catch-Up Growth on Health and Well-Being in Young Adults

Gestational Age Correlates with Skin Reflectance in Newborn Infants of 24–42 Weeks Gestation

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