Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression in two districts of southeast China

Li, Bin; Xu, Xijin; Zhu, Yueqin; Cao, Jun; Zhang, Yuling; Huo, Xia

doi:10.1038/srep21004

Cited by 30 publications

(11 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Maternal whole blood sample was drawn using 6mL Vacutainer tubes containing 10.8 mg of K2-EDTA (dipotassium-ethylene diaminetetraacetic acid) as an anticoagulant and stored at -20°C (47). Umbilical cord blood was collected shortly after delivery with an EDTA- containing tube and stored at −20°C (39, 48, 49). Maternal urine samples were collected in the morning into polypropylene conical centrifuge tubes during the hospital stay (50).…”

Section: Methodsmentioning

confidence: 99%

Metal concentrations in pregnant women and neonates from informal electronic waste recycling

Kim

Zhang

et al. 2018

J Expo Sci Environ Epidemiol

Self Cite

View full text Add to dashboard Cite

Electronic waste (e-waste) is the fastest growing solid waste stream worldwide and mostly ends up in developing countries where residents use primitive methods for recycling. The most infamous e-waste recycling town, Guiyu in Southeast China, has been recycling since the mid-1990s. E-waste contains several harmful chemicals, including lead (Pb), cadmium (Cd), chromium (Cr), and manganese (Mn). In 2011-12, the e-waste Recycling Exposures and Community Health (e-REACH) Study enrolled 634 pregnant women living in Guiyu and Haojiang, a control site, both in Shantou, China. The women completed a questionnaire and gave maternal blood, cord blood, and maternal urine, which were analyzed for Pb, Cd, Cr, and Mn. Maternal blood Pb, Cd, and Cr concentrations were significantly higher in Guiyu compared to Haojiang. In Guiyu, the geometric mean of Pb concentration in maternal blood was 6.66 µg/dL (range: 1.87-27.09 µg/dL) and was 1.74-fold greater than in Haojiang (95% CI: 1.60, 1.89). In cord blood, Pb concentration was 1.53-fold higher in Guiyu (95% CI: 1.38, 1.68). In maternal urine, Cd (ratio: 2.15, 95% CI: 1.72, 2.69) and Mn (ratio: 2.60, 95% CI: 2.04, 3.31) concentrations were significantly higher in Guiyu in comparison to Haojiang. In conclusion, pregnant women in Guiyu were at risk for increased exposure to heavy metals.

show abstract

Section: Methodsmentioning

confidence: 99%

Metal concentrations in pregnant women and neonates from informal electronic waste recycling

Kim

Zhang

et al. 2018

J Expo Sci Environ Epidemiol

Self Cite

View full text Add to dashboard Cite

show abstract

“…This study showed that dimethyl phthalate (DMP) and diethyl phthalate (DEP) did not differ by sex in their associations with any genes tested. However, DEHP was associated with MT and MT-2A only in female placentas [ 50 ]. While this study highlights the importance of considering placental/fetal sex, several factors must be taken into account when interpreting these findings.…”

Section: Sex-specific Placental Outcomesmentioning

confidence: 99%

Impacts of bisphenol A (BPA) and phthalate exposures on epigenetic outcomes in the human placenta

Strakovsky

Schantz

2018

Environmental Epigenetics

View full text Add to dashboard Cite

The placenta guides fetal growth and development. Bisphenol A (BPA) and phthalates are widespread environmental contaminants and endocrine disruptors, and the placental epigenetic response to these chemicals is an area of growing research interest. Therefore, our objective was to summarize research linking BPA or phthalate exposure to placental outcomes in human pregnancies, with a particular focus on epigenetic endpoints. In PubMed, studies were selected for review (without limiting start date and ending on 1 May 2018) if they reported any direct effects of BPA or phthalates on the placenta in humans. Collectively, available studies suggest that BPA and phthalate exposures are associated with changes to placental micro-RNA expression, DNA methylation, and genomic imprinting. Furthermore, several studies suggest that fetal sex may be an important modifier of placental outcomes in response to these chemicals. Studies in humans demonstrate associations of BPA and phthalate exposure with adverse placental outcomes. Moving forward, more studies should consider sex differences (termed “placental sex”) in the measured outcomes, and should utilize appropriate statistical approaches to assess modification by fetal sex. Furthermore, more consistent sample collection and molecular outcome assessment paradigms will be indispensable for making progress in the field. These advances, together with improved non-invasive tools for measuring placental function and outcomes across pregnancy, will be critical for understanding the mechanisms driving placental epigenetic disruption in response to BPA and phthalates, and how these disruptions translate into placental and fetal health.

show abstract

“…Di-(2-ethylhexyl)-phthalate (DEHP) is the most widely-used phthalate, and is listed as a priority hazardous substance by the European Community, the United States Environmental Protection Agency, and the China National Environmental Monitoring Center [ 7 , 8 ]. Previous studies showed that DEHP and its dominant metabolites, mono (2-ethylehxyl) phthalate (MEHP) and phthalic acid (PA), the major intermediate degradation products of most PAEs (including DEHP), produce adverse developmental, neurological, respiratory, and immune effects in humans [ 4 , 9 , 10 , 11 , 12 , 13 ]. Therefore, discovering efficient DEHP degraders with high environmental persistence and wide availability is urgently required, as is establishing remediation strategies to eliminate DEHP and its metabolites from the environment.…”

Section: Introductionmentioning

confidence: 99%

Biodegradation of Di-(2-ethylhexyl) Phthalate by Rhodococcus ruber YC-YT1 in Contaminated Water and Soil

Yang

Ren

Yang

et al. 2018

IJERPH

View full text Add to dashboard Cite

Di-(2-ethylehxyl) phthalate (DEHP) is one of the most broadly representative phthalic acid esters (PAEs) used as a plasticizer in polyvinyl chloride (PVC) production, and is considered to be an endocrine-disrupting chemical. DEHP and its monoester metabolites are responsible for adverse effects on human health. An efficient DEHP-degrading bacterial strain Rhodococcus ruber YC-YT1, with super salt tolerance (0–12% NaCl), is the first DEHP-degrader isolated from marine plastic debris found in coastal saline seawater. Strain YC-YT1 completely degraded 100 mg/L DEHP within three days (pH 7.0, 30 °C). According to high-performance liquid chromatography–mass spectrometry (HPLC-MS) analysis, DEHP was transformed by strain YC-YT1 into phthalate (PA) via mono (2-ethylehxyl) phthalate (MEHP), then PA was used for cell growth. Furthermore, YC-YT1 metabolized initial concentrations of DEHP ranging from 0.5 to 1000 mg/L. Especially, YC-YT1 degraded up to 60% of the 0.5 mg/L initial DEHP concentration. Moreover, compared with previous reports, strain YC-YT1 had the largest substrate spectrum, degrading up to 13 kinds of PAEs as well as diphenyl, p-nitrophenol, PA, benzoic acid, phenol, protocatechuic acid, salicylic acid, catechol, and 1,2,3,3-tetrachlorobenzene. The excellent environmental adaptability of strain YC-YT1 contributed to its ability to adjust its cell surface hydrophobicity (CSH) so that 79.7–95.9% of DEHP-contaminated agricultural soil, river water, coastal sediment, and coastal seawater were remedied. These results demonstrate that R. ruber YC-YT1 has vast potential to bioremediate various DEHP-contaminated environments, especially in saline environments.

show abstract

Neonatal phthalate ester exposure induced placental MTs, FATP1 and HFABP mRNA expression in two districts of southeast China

Cited by 30 publications

References 32 publications

Metal concentrations in pregnant women and neonates from informal electronic waste recycling

Metal concentrations in pregnant women and neonates from informal electronic waste recycling

Impacts of bisphenol A (BPA) and phthalate exposures on epigenetic outcomes in the human placenta

Biodegradation of Di-(2-ethylhexyl) Phthalate by Rhodococcus ruber YC-YT1 in Contaminated Water and Soil

Contact Info

Product

Resources

About