Neonatal Thymectomy Prevents Spontaneous Diabetes Mellitus in the BB/W Rat

Like, A A; Kislauskis, Edward H.; Williams, Robert R.; Rossini, A A

doi:10.1126/science.7041259

Cited by 191 publications

(102 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…For example, in the DP-BB rat model of diabetes, an early time interval has been identified in which diabetes can be prevented (1). Thymectomy of DP-BB rats around 30 days of age prevents IDDM, whereas thymectomy at day 60 has no effect (13). Accordingly, injection with regulatory RT6 þ T cells from DR-BB rats in the period from 21 to 60 days of age prevents diabetes in DP-BB rats, while injection from 60 to 100 days does not influence the disease (14).…”

Section: Introductionmentioning

confidence: 86%

Long-term prophylactic insulin treatment can prevent spontaneous diabetes and thyroiditis development in the diabetes-prone bio-breeding rat, while short-term treatment is ineffective

Visser

Klatter

Vis

et al. 2003

European Journal of Endocrinology

View full text Add to dashboard Cite

Objective: Prophylactic insulin treatment has been demonstrated to reduce diabetes development in the diabetes-prone bio-breeding (DP-BB) rat. These prophylactic insulin treatments were given from 50 to 150 days of age. However, several data indicate that the diabetogenic process in DP-BB rats starts well before day 50. Design and methods: DP-BB rats were given bovine insulin pellets from 21 to 60 days of age, from 21 to 100 days of age and from 60 to 100 days of age. At 160 days of age a glucose tolerance test was performed to establish b-cell function and pancreata collected for histological analysis. Results: Prophylactic insulin treatment from 21 to 100 days of age gave a 42% reduction of diabetes incidence. The other treatment protocols had no effect. Non-diabetic rats treated with insulin from day 21 to 100 showed normal glucose tolerance and no sign of insulitis at 160 days of age. Non-diabetic rats of the control group and the other treatment groups showed normal glucose tolerance, but a slight increase of insulitis. Interestingly, the 21-100 day treated rats showed reduced serum levels of anti-colloid antibodies as compared with the control group. Conclusions: These results show that short-term prophylactic insulin treatment cannot prevent diabetes and thyroiditis development in DP-BB rats. The prophylactic treatment must start well before 60 days of age and be prolonged into the phase when the rats normally become diabetic to reduce diabetes incidence. These findings imply that in the human situation prophylactic insulin treatment must be prolonged over the normal range of diabetes onset.

show abstract

Section: Introductionmentioning

confidence: 86%

Long-term prophylactic insulin treatment can prevent spontaneous diabetes and thyroiditis development in the diabetes-prone bio-breeding rat, while short-term treatment is ineffective

Visser

Klatter

Vis

et al. 2003

European Journal of Endocrinology

View full text Add to dashboard Cite

show abstract

“…Like et al [9] have also reported a similar effect of neonatal thymectomy on insulitis in BB/W rats that spontaneously develop insulin-dependent diabetes mellitus [13,15]. Neither paper explains why complete abolishment of insulitis was unsuccessful in thymectomized mice and rats.…”

mentioning

confidence: 82%

Absence of Insulitis and Overt Diabetes in Athymic Nude Mice with NOD Genetic Background

Makino

Harada

Kishimoto

et al. 1986

Experimental Animals

View full text Add to dashboard Cite

“…1 " 4 (2) modification and possible prevention of the syndrome by treatment with anti-lymphocyte serum; 5 (3) possible prevention by neonatal thymectomy 6 and by bone marrow transplantation from normal rats; 7 (4) the demonstration of passive transfer of insulitis by lymphocytes from dia-betic rats injected into nude mice; 8 and (5) the presence of lymphopenia before and after development of diabetes.…”

mentioning

confidence: 99%

Islet Cell Surface Antibodies and Lymphocyte Antibodies in the Spontaneously Diabetic BB Wistar Rat

Dyrberg¹,

Nakhooda²,

Bækkeskov³

et al. 1982

Diabetes

View full text Add to dashboard Cite

show abstract

Neonatal Thymectomy Prevents Spontaneous Diabetes Mellitus in the BB/W Rat

Cited by 191 publications

References 13 publications

Long-term prophylactic insulin treatment can prevent spontaneous diabetes and thyroiditis development in the diabetes-prone bio-breeding rat, while short-term treatment is ineffective

Long-term prophylactic insulin treatment can prevent spontaneous diabetes and thyroiditis development in the diabetes-prone bio-breeding rat, while short-term treatment is ineffective

Absence of Insulitis and Overt Diabetes in Athymic Nude Mice with NOD Genetic Background

Islet Cell Surface Antibodies and Lymphocyte Antibodies in the Spontaneously Diabetic BB Wistar Rat

Contact Info

Product

Resources

About