Neonatal thyroid-stimulating hormone level is influenced by neonatal, maternal, and pregnancy factors

Trumpff, Caroline; Vandevijvere, Stefanie; Moreno‐Reyes, Rodrigo; Vanderpas, Jean; Tafforeau, Jean; Oyen, Herman Van; Schepper, Jean De

doi:10.1016/j.nutres.2015.09.002

Cited by 46 publications

(53 citation statements)

References 49 publications

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“…Many factors other than iodine deficiency can influence TSH measured at birth such as the timing of the blood sampling, the use of iodine-containing antiseptics around birth, or exposure to some organochlorines called endocrine disruptors (20, 21). The effect of MID during pregnancy on children behavioral development should thus be complemented by prospective studies using other markers of iodine deficiency during from first trimester of pregnancy, such as maternal UIC or maternal hypothyroxinemia.…”

Section: Discussionmentioning

confidence: 99%

“…However, some factors other than iodine deficiency can increase TSH concentration at birth such as timing of testing, mothers or newborn health condition, and drug intake (20, 21). We previously reported no association between elevated TSH measured at birth and cognitive and psychomotor development of preschool children when confounding factors were taken into account (22, 23).…”

Section: Introductionmentioning

confidence: 99%

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No Association between Elevated Thyroid-Stimulating Hormone at Birth and Parent-Reported Problem Behavior at Preschool Age

et al. 2016

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ObjectivesMild level of iodine deficiency during pregnancy may reduce maternal thyroid hormone production and supply to the fetus hence affecting brain neurodevelopment. The aim of the present study was to investigate the association between elevated neonatal thyroid-stimulating hormone (TSH) level (>5 mU/L), used as a marker of maternal mild iodine deficiency during late pregnancy, and behavioral development of preschool children.MethodsThis retrospective cohort study included 310 Belgian mothers and their children aged 4–5 years old with TSH levels in the range of 0.45–15 mU/L at birth. The TSH level was measured in dried blood spots on filter paper collected by heel stick 3–5 days after birth. Low birth weight, prematurely born children, or children with congenital hypothyroidism were excluded. The degree of behavioral problems was evaluated using the Child Behavior Check List (CBCL) for age 1½–5 years questionnaire. Relevant socioeconomic, maternal, and child factors were also collected.ResultsTSH concentrations and CBCL scores were not associated both in univariate analysis and when adjusting for confounding factors in multivariate analysis.DiscussionElevated TSH concentrations measured at birth was not associated with behavioral development scores.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

No Association between Elevated Thyroid-Stimulating Hormone at Birth and Parent-Reported Problem Behavior at Preschool Age

et al. 2016

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“…In pregnancy, iodine deficiency can increase the risk of spontaneous abortion, perinatal mortality, birth defects and neurological disorders [45], and is considered by the WHO as the most important preventable cause of brain damage.…”

Section: Micronutrientsmentioning

confidence: 99%

Maternal Diet and Nutrient Requirements in Pregnancy and Breastfeeding. An Italian Consensus Document

Marangoni¹,

et al. 2016

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The importance of lifestyle and dietary habits during pregnancy and breastfeeding, for health of mothers and their offspring, is widely supported by the most recent scientific literature. The consumption of a varied and balanced diet from the preconceptional period is essential to ensure both maternal well-being and pregnancy outcomes. However, the risk of inadequate intakes of specific micronutrients in pregnancy and lactation is high even in the most industrialized countries. This particularly applies to docosahexaenoic acid (DHA), iron, iodine, calcium, folic acid, and vitamin D, also in the Italian population. Moreover, the risk of not reaching the adequate nutrient supply is increased for selected groups of women of childbearing age: those following exclusion diets, underweight or overweight/obese, smokers, adolescents, mothers who have had multiple or close pregnancies, and those with previous unfavorable pregnancy outcomes.

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“…This difference can be explained on the basis of a surge in catecholamine secretion during the process of parturition and this can be more in asphyxiated newborns and in vaginally delivered newborns compared to those born by elective cesarean section [19,20]. In contrast, two studies have shown no difference in neonatal TSH levels according to the mode of delivery [21,22].…”

Section: Original Research Articlementioning

confidence: 99%

The emerging role of a newborn screening program for congenital hypothyroidism: a prospective study

Kumar

Ahmed²,

Upadhyay

2020

IJPR

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All newborns with the gestational age of 34 weeks or more delivered in the hospital during the study period were screened for hypothyroidism and analyzed. Result: A total of 1363 babies were enrolled out of which 1272 were an eligible candidate for the study period. Numbers of term deliveries were 1109 and preterm deliveries were 163, with 665 (52.28%) males and 607 (47.72%) female babies. Of the total eligible neonates, 1109 were term babies and 163 were preterm babies with more than 34 weeks. Neonatal thyroid-stimulating hormone was estimated in all 1272 neonates out of which 2 cases were positive for CH, 12 cases had initially high values between 10-19 µIU/L but later on, repeat testing after two weeks were found to be within normal limits and rest all 1258 cases were normal. Conclusion: Timely diagnosis and treatment of CH are important in order to prevent its consequences. NBS is the need of the hour for early diagnosis of CH, which is simple, fast as well as cost-effective.

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Neonatal thyroid-stimulating hormone level is influenced by neonatal, maternal, and pregnancy factors

Cited by 46 publications

References 49 publications

No Association between Elevated Thyroid-Stimulating Hormone at Birth and Parent-Reported Problem Behavior at Preschool Age

No Association between Elevated Thyroid-Stimulating Hormone at Birth and Parent-Reported Problem Behavior at Preschool Age

Maternal Diet and Nutrient Requirements in Pregnancy and Breastfeeding. An Italian Consensus Document

The emerging role of a newborn screening program for congenital hypothyroidism: a prospective study

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